| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 90,862 | 406,903 | +316,041 | 0.02 | 0.06 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 818,978 | 1,087,228 | +268,250 | 0.01 | 0.01 | 0.00 | buy |
| Lombard Odier Asset Management (USA) Corp | 2,405,998 | 2,664,077 | +258,079 | 2.72 | 2.41 | -0.31 | buy |
| Parkman Healthcare Partners LLC | 289,841 | 497,870 | +208,029 | 0.74 | 1.16 | +0.42 | buy |
| CANTOR FITZGERALD, L. P. | 247,966 | 334,192 | +86,226 | 0.93 | 0.17 | -0.76 | buy |
| Ikarian Capital, LLC | 506,665 | 587,343 | +80,678 | 0.57 | 0.47 | -0.10 | buy |
| Polar Capital Holdings Plc | 940,164 | 1,000,000 | +59,836 | 0.11 | 0.09 | -0.02 | buy |
| NEOS Investment Management LLC | 37,164 | 51,712 | +14,548 | 0.03 | 0.03 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 76,840 | 85,701 | +8,861 | 0.09 | 0.12 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,591 | 4,674 | +83 | 0.04 | 0.04 | -0.00 | buy |
| Quantum Portfolio Management LLC | 14,836 | 14,415 | -421 | 0.16 | 0.14 | -0.02 | sell |
| BIT Capital GmbH | 101,235 | 92,429 | -8,806 | 0.15 | 0.16 | +0.01 | sell |
| Redmile Group, LLC | 2,014,296 | 1,899,317 | -114,979 | 2.31 | 2.03 | -0.28 | sell |
| Aquilo Capital Management, LLC | 500,214 | 317,214 | -183,000 | 9.16 | 6.49 | -2.67 | sell |
| Cormorant Asset Management, LP | 625,000 | 400,000 | -225,000 | 0.69 | 0.39 | -0.30 | sell |
| TCG Crossover Management, LLC | 3,295,350 | 3,033,560 | -261,790 | 6.53 | 4.67 | -1.85 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 320,000 | -280,000 | 0.02 | 0.01 | -0.01 | sell |
| Deep Track Capital, LP | 1,359,745 | 1,000,000 | -359,745 | 0.77 | 0.58 | -0.19 | sell |
| Logos Global Management LP | 1,476,061 | 200,000 | -1,276,061 | 3.23 | 0.41 | -2.82 | sell |