| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 640,000 | +640,000 | 0.00 | 0.20 | +0.20 | buy |
| Saturn V Capital Management LP | 0 | 481,127 | +481,127 | 0.00 | 3.13 | +3.13 | buy |
| MORGAN STANLEY | 303,993 | 721,417 | +417,424 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 338,681 | +338,681 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 782,941 | 1,110,230 | +327,289 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 146,500 | 467,800 | +321,300 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 116,760 | 436,697 | +319,937 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 90,862 | 406,903 | +316,041 | 0.02 | 0.06 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 818,978 | 1,087,228 | +268,250 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 260,000 | +260,000 | 0.00 | 0.39 | +0.39 | buy |
| Lombard Odier Asset Management (USA) Corp | 2,405,998 | 2,664,077 | +258,079 | 13.89 | 13.46 | -0.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 228,644 | +228,644 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 289,841 | 497,870 | +208,029 | 0.75 | 1.16 | +0.41 | buy |
| Schonfeld Strategic Advisors LLC | 75,037 | 166,000 | +90,963 | 0.01 | 0.02 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 247,966 | 334,192 | +86,226 | 0.95 | 0.55 | -0.40 | buy |
| Ikarian Capital, LLC | 506,665 | 587,343 | +80,678 | 1.03 | 1.05 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 99,107 | 169,392 | +70,285 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 65,259 | +65,259 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 940,164 | 1,000,000 | +59,836 | 0.11 | 0.09 | -0.02 | buy |
| Cubist Systematic Strategies, LLC | 9,438 | 46,305 | +36,867 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 146,852 | 171,155 | +24,303 | 0.08 | 0.09 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 19,196 | +19,196 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 149,397 | 168,417 | +19,020 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 17,490 | +17,490 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 37,164 | 51,712 | +14,548 | 0.03 | 0.03 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 16,256 | 30,632 | +14,376 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,390 | +11,390 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 76,840 | 85,701 | +8,861 | 0.04 | 0.04 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 76,200 | 83,300 | +7,100 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 17,155 | 21,078 | +3,923 | 0.02 | 0.02 | +0.01 | buy |
| Values First Advisors, Inc. | 0 | 3,091 | +3,091 | 0.00 | 0.03 | +0.03 | buy |
| OSAIC HOLDINGS, INC. | 12,841 | 13,159 | +318 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 469 | 754 | +285 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,591 | 4,674 | +83 | 0.04 | 0.04 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,417 | 29,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 18,421 | 18,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 200,000 | 200,000 | 0 | 0.38 | 0.31 | -0.08 | hold |
| MANGROVE PARTNERS IM, LLC | 385,408 | 385,408 | 0 | 0.56 | 0.60 | +0.04 | hold |
| Duquesne Family Office LLC | 387,400 | 387,400 | 0 | 0.26 | 0.25 | -0.01 | hold |
| Vestcor Inc | 8,800 | 8,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 1.94 | 1.66 | -0.28 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 2.02 | 1.79 | -0.24 | hold |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 4.56 | 3.70 | -0.86 | hold |
| Frazier Life Sciences Management, L.P. | 1,148,591 | 1,148,591 | 0 | 1.02 | 0.84 | -0.18 | hold |
| Artia Global Partners LP | 52,476 | 52,476 | 0 | 0.26 | 0.27 | +0.01 | hold |
| ADAR1 Capital Management, LLC | 40,290 | 40,290 | 0 | 0.15 | 0.12 | -0.03 | hold |
| GAMMA Investing LLC | 859 | 859 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 58,333 | 58,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 177,834 | 177,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SG Americas Securities, LLC | 343,196 | 343,190 | -6 | 0.04 | 0.02 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| Quantum Portfolio Management LLC | 14,836 | 14,415 | -421 | 0.16 | 0.14 | -0.02 | sell |
| BARCLAYS PLC | 5,570 | 3,333 | -2,237 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 73,806 | 70,661 | -3,145 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 4,716 | 0 | -4,716 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Preferred, LLC | 5,315 | 0 | -5,315 | 0.02 | 0.00 | -0.02 | sell |
| BLAIR WILLIAM & CO/IL | 25,432 | 20,000 | -5,432 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 6,000 | 0 | -6,000 | 0.05 | 0.00 | -0.05 | sell |
| BIT Capital GmbH | 101,235 | 92,429 | -8,806 | 0.17 | 0.16 | -0.01 | sell |
| Jump Financial, LLC | 12,342 | 0 | -12,342 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 21,803 | 0 | -21,803 | 0.01 | 0.00 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,066 | 0 | -24,066 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 39,100 | 0 | -39,100 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 74,220 | 0 | -74,220 | 0.01 | 0.00 | -0.01 | sell |
| Redmile Group, LLC | 2,014,296 | 1,899,317 | -114,979 | 2.31 | 2.03 | -0.28 | sell |
| STEMPOINT CAPITAL LP | 124,866 | 0 | -124,866 | 0.70 | 0.00 | -0.70 | sell |
| Nicholas Investment Partners, LP | 150,480 | 0 | -150,480 | 0.30 | 0.00 | -0.30 | sell |
| Octagon Capital Advisors LP | 176,000 | 0 | -176,000 | 0.55 | 0.00 | -0.55 | sell |
| Aquilo Capital Management, LLC | 500,214 | 317,214 | -183,000 | 9.16 | 6.49 | -2.67 | sell |
| Hudson Bay Capital Management LP | 208,064 | 0 | -208,064 | 0.03 | 0.00 | -0.03 | sell |
| Cormorant Asset Management, LP | 625,000 | 400,000 | -225,000 | 0.69 | 0.39 | -0.31 | sell |
| TCG Crossover Management, LLC | 3,295,350 | 3,033,560 | -261,790 | 6.53 | 4.67 | -1.85 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 320,000 | -280,000 | 0.02 | 0.01 | -0.01 | sell |
| Deep Track Capital, LP | 1,359,745 | 1,000,000 | -359,745 | 0.77 | 0.58 | -0.19 | sell |
| First Turn Management, LLC | 537,338 | 0 | -537,338 | 1.66 | 0.00 | -1.66 | sell |
| Logos Global Management LP | 1,476,061 | 200,000 | -1,276,061 | 3.23 | 0.41 | -2.82 | sell |
| Artal Group S.A. | 2,779,619 | 0 | -2,779,619 | 1.36 | 0.00 | -1.36 | sell |