| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 198,647 | 298,512 | +99,865 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 228,509 | 307,363 | +78,854 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 252,421 | 279,637 | +27,216 | 0.04 | 0.04 | -0.01 | buy |
| Ikarian Capital, LLC | 873,568 | 900,784 | +27,216 | 0.46 | 0.26 | -0.20 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 22,644 | +22,644 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 789,039 | 801,306 | +12,267 | 0.11 | 0.08 | -0.03 | buy |
| HRT FINANCIAL LP | 0 | 10,887 | +10,887 | 0.00 | 0.00 | +0.00 | buy |
| EHP Funds Inc. | 0 | 10,673 | +10,673 | 0.00 | 0.07 | +0.07 | buy |
| BANK OF MONTREAL /CAN/ | 145,812 | 153,782 | +7,970 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,218 | +4,218 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 59,312 | 63,247 | +3,935 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 16,837 | 20,374 | +3,537 | 0.03 | 0.03 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 39,600 | 42,600 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 8,333 | 9,915 | +1,582 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 7,035 | 7,136 | +101 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 172,834 | 172,873 | +39 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,428 | 2,447 | +19 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 28 | 29 | +1 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | 29,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 17 | 17 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 10,194 | 10,194 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 2,164,777 | 2,164,777 | 0 | 1.34 | 1.09 | -0.24 | hold |
| Nantahala Capital Management, LLC | 1,042,427 | 1,042,427 | 0 | 0.43 | 0.33 | -0.09 | hold |
| Nextech Invest, Ltd. | 952,400 | 952,400 | 0 | 1.05 | 0.75 | -0.29 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 0.66 | 0.46 | -0.19 | hold |
| Parallel Advisors, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 62,459 | 62,459 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 1.06 | 0.91 | -0.16 | hold |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 1.83 | 1.41 | -0.42 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 2.01 | 0.77 | -1.24 | hold |
| Frazier Life Sciences Management, L.P. | 970,130 | 970,130 | 0 | 0.23 | 0.15 | -0.07 | hold |
| ADAR1 Capital Management, LLC | 18,643 | 18,643 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Siren, L.L.C. | 2,911,438 | 2,911,438 | 0 | 0.87 | 0.59 | -0.28 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,817 | 1,816 | -1 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 667 | 651 | -16 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 308,331 | 308,289 | -42 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 700 | 600 | -100 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,165 | 978 | -187 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 6,196 | 5,865 | -331 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,446 | 8,232 | -1,214 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,474 | 1,773 | -1,701 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,211,758 | 1,207,724 | -4,034 | 0.00 | 0.00 | -0.00 | sell |
| Lombard Odier Asset Management (USA) Corp | 1,849,734 | 1,844,948 | -4,786 | 1.96 | 1.61 | -0.34 | sell |
| OSAIC HOLDINGS, INC. | 69,381 | 62,171 | -7,210 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 11,615 | 0 | -11,615 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 18,421 | 0 | -18,421 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 27,149 | 7,708 | -19,441 | 0.04 | 0.01 | -0.03 | sell |
| Massar Capital Management, LP | 19,863 | 0 | -19,863 | 0.09 | 0.00 | -0.09 | sell |
| Saturn V Capital Management LP | 34,737 | 0 | -34,737 | 0.08 | 0.00 | -0.08 | sell |
| JANE STREET GROUP, LLC | 37,813 | 0 | -37,813 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 175,862 | 83,219 | -92,643 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 168,235 | 61,832 | -106,403 | 0.00 | 0.00 | -0.00 | sell |