| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 510,204 | +510,204 | 0.00 | 0.73 | +0.73 | buy |
| Artal Group S.A. | 2,500,000 | 3,000,000 | +500,000 | 1.07 | 1.78 | +0.71 | buy |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 0.77 | +0.77 | buy |
| Lombard Odier Asset Management (Europe) Ltd | 3,443,912 | 3,612,877 | +168,965 | 1.77 | 4.21 | +2.44 | buy |
| MORGAN STANLEY | 0 | 62,808 | +62,808 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 192,879 | 232,942 | +40,063 | 0.35 | 0.57 | +0.23 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 27,102 | +27,102 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 21,737 | +21,737 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 6,333 | +6,333 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 46,400 | 49,200 | +2,800 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 21,324 | 22,427 | +1,103 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 69,113 | 69,946 | +833 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 707 | +707 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 2,170 | 2,270 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,508,416 | 1,508,416 | 0 | 0.40 | 0.66 | +0.26 | hold |
| RHUMBLINE ADVISERS | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 178 | 178 | 0 | 0.00 | 0.00 | +0.00 | hold |
| M28 Capital Management LP | 363,800 | 363,800 | 0 | 4.10 | 5.24 | +1.14 | hold |
| TCG Crossover Management, LLC | 2,104,875 | 2,104,875 | 0 | 3.04 | 4.05 | +1.01 | hold |
| Deep Track Capital, LP | 1,951,580 | 1,951,580 | 0 | 0.74 | 1.19 | +0.44 | hold |
| Frazier Life Sciences Management, L.P. | 881,173 | 881,173 | 0 | 0.58 | 0.82 | +0.24 | hold |
| Lynx1 Capital Management LP | 235,787 | 235,787 | 0 | 1.53 | 1.61 | +0.08 | hold |
| CITIGROUP INC | 58,333 | 58,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 177,834 | 177,834 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 620 | 0 | -620 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 98,326 | 93,198 | -5,128 | 0.02 | 0.05 | +0.03 | sell |
| BLAIR WILLIAM & CO/IL | 38,986 | 25,548 | -13,438 | 0.00 | 0.00 | +0.00 | sell |
| CANTOR FITZGERALD, L. P. | 168,193 | 146,777 | -21,416 | 0.04 | 0.52 | +0.48 | sell |
| Woodline Partners LP | 166,652 | 49,272 | -117,380 | 0.02 | 0.01 | -0.01 | sell |
| Lombard Odier Asset Management (USA) Corp | 4,057,932 | 3,879,173 | -178,759 | 5.79 | 7.93 | +2.14 | sell |
| GOLDMAN SACHS GROUP INC | 266,667 | 0 | -266,667 | 0.00 | 0.00 | -0.00 | sell |
| Aquilo Capital Management, LLC | 1,312,233 | 1,043,284 | -268,949 | 11.68 | 12.71 | +1.03 | sell |