| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 721,417 | 1,663,068 | +941,651 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 200,000 | 1,049,676 | +849,676 | 0.31 | 0.51 | +0.20 | buy |
| Redmile Group, LLC | 1,899,317 | 2,399,317 | +500,000 | 2.03 | 1.15 | -0.88 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 499,066 | +499,066 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 168,417 | 488,889 | +320,472 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 70,661 | 356,071 | +285,410 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 211,507 | +211,507 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 334,192 | 539,726 | +205,534 | 0.55 | 0.14 | -0.41 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.12 | +0.12 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 171,155 | 351,527 | +180,372 | 0.09 | 0.07 | -0.02 | buy |
| Point72 Asset Management, L.P. | 467,800 | 633,100 | +165,300 | 0.03 | 0.01 | -0.02 | buy |
| Woodline Partners LP | 406,903 | 498,732 | +91,829 | 0.06 | 0.02 | -0.04 | buy |
| Trexquant Investment LP | 0 | 63,663 | +63,663 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 46,305 | 106,320 | +60,015 | 0.01 | 0.01 | -0.00 | buy |
| Aquilo Capital Management, LLC | 317,214 | 367,214 | +50,000 | 6.49 | 4.33 | -2.16 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,701 | 128,990 | +43,289 | 0.04 | 0.02 | -0.02 | buy |
| Walleye Capital LLC | 0 | 36,397 | +36,397 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 19,196 | 54,746 | +35,550 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 13,159 | 40,867 | +27,708 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 0 | 19,467 | +19,467 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 19,467 | +19,467 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 17,515 | +17,515 | 0.00 | 0.06 | +0.06 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 16,360 | +16,360 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 83,300 | 98,800 | +15,500 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 11,390 | 24,123 | +12,733 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 9,963 | +9,963 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 30,632 | 36,885 | +6,253 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,674 | 10,772 | +6,098 | 0.04 | 0.03 | -0.01 | buy |
| GAMMA Investing LLC | 859 | 6,092 | +5,233 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,333 | 6,126 | +2,793 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 58,333 | 60,502 | +2,169 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,784 | +1,784 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,566 | +1,566 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 632 | +632 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 21,078 | 21,217 | +139 | 0.02 | 0.01 | -0.01 | buy |
| RHUMBLINE ADVISERS | 754 | 841 | +87 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 51 | +51 | 0.00 | 0.00 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,417 | 29,417 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 18,421 | 18,421 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 640,000 | 640,000 | 0 | 0.20 | 0.08 | -0.12 | hold |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 1.66 | 0.85 | -0.81 | hold |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 1.79 | 0.78 | -1.01 | hold |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 3.70 | 1.25 | -2.45 | hold |
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 4.67 | 2.04 | -2.63 | hold |
| Frazier Life Sciences Management, L.P. | 1,148,591 | 1,148,591 | 0 | 0.84 | 0.33 | -0.51 | hold |
| Siren, L.L.C. | 2,831,770 | 2,831,770 | 0 | 2.58 | 0.86 | -1.72 | hold |
| BANK OF MONTREAL /CAN/ | 65,259 | 65,007 | -252 | 0.00 | 0.00 | -0.00 | sell |
| Quantum Portfolio Management LLC | 14,415 | 11,861 | -2,554 | 0.14 | 0.04 | -0.10 | sell |
| Values First Advisors, Inc. | 3,091 | 0 | -3,091 | 0.03 | 0.00 | -0.03 | sell |
| HSBC HOLDINGS PLC | 177,834 | 172,834 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 497,870 | 491,080 | -6,790 | 1.16 | 0.45 | -0.71 | sell |
| Vestcor Inc | 8,800 | 0 | -8,800 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,490 | 0 | -17,490 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 40,290 | 18,000 | -22,290 | 0.12 | 0.03 | -0.10 | sell |
| SG Americas Securities, LLC | 343,190 | 317,628 | -25,562 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 169,392 | 142,052 | -27,340 | 0.01 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 30,600 | 0 | -30,600 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 166,000 | 123,200 | -42,800 | 0.02 | 0.01 | -0.02 | sell |
| NEOS Investment Management LLC | 51,712 | 0 | -51,712 | 0.03 | 0.00 | -0.03 | sell |
| Artia Global Partners LP | 52,476 | 0 | -52,476 | 0.27 | 0.00 | -0.27 | sell |
| Saturn V Capital Management LP | 481,127 | 395,024 | -86,103 | 3.13 | 1.06 | -2.06 | sell |
| BIT Capital GmbH | 92,429 | 0 | -92,429 | 0.16 | 0.00 | -0.16 | sell |
| CITADEL ADVISORS LLC | 436,697 | 282,737 | -153,960 | 0.01 | 0.00 | -0.01 | sell |
| Logos Global Management LP | 200,000 | 0 | -200,000 | 0.41 | 0.00 | -0.41 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 228,644 | 0 | -228,644 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 260,000 | 0 | -260,000 | 0.39 | 0.00 | -0.39 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 320,000 | 0 | -320,000 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 338,681 | 0 | -338,681 | 0.06 | 0.00 | -0.06 | sell |
| MANGROVE PARTNERS IM, LLC | 385,408 | 0 | -385,408 | 0.60 | 0.00 | -0.60 | sell |
| Duquesne Family Office LLC | 387,400 | 0 | -387,400 | 0.25 | 0.00 | -0.25 | sell |
| Cormorant Asset Management, LP | 400,000 | 0 | -400,000 | 0.39 | 0.00 | -0.39 | sell |
| Ikarian Capital, LLC | 587,343 | 0 | -587,343 | 1.05 | 0.00 | -1.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,110,230 | 473,552 | -636,678 | 0.02 | 0.00 | -0.01 | sell |
| Lombard Odier Asset Management (USA) Corp | 2,664,077 | 1,856,023 | -808,054 | 13.46 | 3.92 | -9.54 | sell |
| Polar Capital Holdings Plc | 1,000,000 | 0 | -1,000,000 | 0.09 | 0.00 | -0.09 | sell |
| Deep Track Capital, LP | 1,000,000 | 0 | -1,000,000 | 0.58 | 0.00 | -0.58 | sell |
| JANUS HENDERSON GROUP PLC | 1,087,228 | 0 | -1,087,228 | 0.01 | 0.00 | -0.01 | sell |