| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 3,033,560 | 3,033,560 | 0 | 0.77 | 0.61 | -0.16 | hold |
| Siren, L.L.C. | 2,911,438 | 2,911,438 | 0 | 0.59 | 0.53 | -0.06 | hold |
| Redmile Group, LLC | 2,164,777 | 2,164,777 | 0 | 1.09 | 0.97 | -0.12 | hold |
| Nantahala Capital Management, LLC | 1,042,427 | 1,542,427 | +500,000 | 0.33 | 0.56 | +0.22 | buy |
| Vivo Capital, LLC | 1,105,454 | 1,105,454 | 0 | 0.46 | 0.43 | -0.03 | hold |
| Nextech Invest, Ltd. | 952,400 | 952,400 | 0 | 0.75 | 0.56 | -0.19 | hold |
| Ikarian Capital, LLC | 900,784 | 865,784 | -35,000 | 0.26 | 0.22 | -0.04 | sell |
| GREAT POINT PARTNERS LLC | 0 | 808,032 | +808,032 | 0.00 | 1.59 | +1.59 | buy |
| MILLENNIUM MANAGEMENT LLC | 298,512 | 659,592 | +361,080 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 476,200 | 476,200 | 0 | 0.91 | 0.91 | +0.01 | hold |
| TFG Asset Management GP Ltd | 0 | 365,369 | +365,369 | 0.00 | 0.47 | +0.47 | buy |
| MORGAN STANLEY | 1,207,724 | 324,630 | -883,094 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 308,289 | 256,340 | -51,949 | 0.01 | 0.00 | -0.00 | sell |
| Lombard Odier Asset Management (USA) Corp | 1,844,948 | 255,901 | -1,589,047 | 1.61 | 0.47 | -1.14 | sell |
| CITADEL ADVISORS LLC | 0 | 244,061 | +244,061 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 279,637 | 209,088 | -70,549 | 0.04 | 0.03 | -0.00 | sell |
| UBS Group AG | 307,363 | 207,513 | -99,850 | 0.00 | 0.00 | -0.00 | sell |
| M28 Capital Management LP | 185,100 | 185,100 | 0 | 1.41 | 0.82 | -0.59 | hold |
| HSBC HOLDINGS PLC | 172,873 | 172,834 | -39 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 153,782 | 160,474 | +6,692 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 83,219 | 155,680 | +72,461 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 114,070 | +114,070 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 78,926 | +78,926 | 0.00 | 0.06 | +0.06 | buy |
| BlackRock, Inc. | 61,832 | 73,153 | +11,321 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 54,380 | +54,380 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 63,247 | 39,344 | -23,903 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 34,962 | +34,962 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,538 | 29,538 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 18,643 | 23,643 | +5,000 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 42,600 | 15,900 | -26,700 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,232 | 13,653 | +5,421 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 5,865 | 12,999 | +7,134 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 600 | 12,027 | +11,427 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,718 | +11,718 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 9,915 | 10,112 | +197 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 7,136 | 5,065 | -2,071 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 651 | 3,991 | +3,340 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,447 | 2,448 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,816 | 2,282 | +466 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,773 | 1,621 | -152 | 0.00 | 0.00 | +0.00 | sell |
| Parallel Advisors, LLC | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 978 | 922 | -56 | 0.00 | 0.00 | +0.00 | sell |
| Steward Partners Investment Advisory, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 29 | 28 | -1 | 0.00 | 0.00 | +0.00 | sell |
| SageView Advisory Group, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 801,306 | 0 | -801,306 | 0.08 | 0.00 | -0.08 | sell |
| WEXFORD CAPITAL LP | 7,708 | 0 | -7,708 | 0.01 | 0.00 | -0.01 | sell |
| PRINCIPAL SECURITIES, INC. | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 10,194 | 0 | -10,194 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 10,887 | 0 | -10,887 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 62,171 | 0 | -62,171 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 62,459 | 0 | -62,459 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 970,130 | 0 | -970,130 | 0.15 | 0.00 | -0.15 | sell |
| EHP Funds Inc. | 10,673 | 0 | -10,673 | 0.07 | 0.00 | -0.07 | sell |
| Virtus Investment Advisers, LLC | 20,374 | 0 | -20,374 | 0.03 | 0.00 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 22,644 | 0 | -22,644 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 4,218 | 0 | -4,218 | 0.00 | 0.00 | -0.00 | sell |