| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,600,385 | 2,664,798 | +64,413 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 1,664,727 | 1,729,921 | +65,194 | 2.77 | 2.08 | -0.69 | buy |
| Alyeska Investment Group, L.P. | 1,464,582 | 1,614,582 | +150,000 | 0.10 | 0.07 | -0.03 | buy |
| Woodline Partners LP | 1,325,784 | 1,325,855 | +71 | 0.13 | 0.09 | -0.05 | buy |
| BlackRock, Inc. | 983,891 | 1,248,956 | +265,065 | 0.00 | 0.00 | -0.00 | buy |
| Durable Capital Partners LP | 1,657,126 | 1,023,706 | -633,420 | 0.24 | 0.11 | -0.13 | sell |
| VANGUARD GROUP INC | 991,429 | 982,618 | -8,811 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 833,333 | 833,333 | 0 | 0.60 | 0.34 | -0.26 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 636,333 | 631,663 | -4,670 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 549,052 | 454,512 | -94,540 | 1.22 | 0.70 | -0.52 | sell |
| MORGAN STANLEY | 121,370 | 433,175 | +311,805 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 158,535 | 421,409 | +262,874 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 521,400 | 419,118 | -102,282 | 0.01 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 415,552 | 397,259 | -18,293 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 377,033 | +377,033 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 205,270 | 331,736 | +126,466 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 314,522 | 326,087 | +11,565 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 249,358 | 236,736 | -12,622 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 74,094 | 146,598 | +72,504 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 166,666 | 118,279 | -48,387 | 0.67 | 0.31 | -0.36 | sell |
| JPMORGAN CHASE & CO | 8,452 | 116,306 | +107,854 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 143,160 | 116,291 | -26,869 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 256,682 | 114,800 | -141,882 | 0.04 | 0.01 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,063 | 103,766 | +101,703 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 24,341 | 99,963 | +75,622 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 0 | 98,108 | +98,108 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 20,322 | 96,084 | +75,762 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 37,247 | 94,966 | +57,719 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 34,584 | 78,584 | +44,000 | 0.66 | 0.84 | +0.18 | buy |
| ALGERT GLOBAL LLC | 14,030 | 72,931 | +58,901 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 79,586 | 72,441 | -7,145 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 162 | 72,117 | +71,955 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 92,122 | 71,330 | -20,792 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 34,495 | 68,941 | +34,446 | 0.00 | 0.00 | +0.00 | buy |
| C WorldWide Group Holding A/S | 66,666 | 66,666 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 29,454 | 58,972 | +29,518 | 0.01 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 54,005 | +54,005 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 55,660 | 52,311 | -3,349 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 51,822 | +51,822 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 21,575 | 44,869 | +23,294 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 39,857 | 42,033 | +2,176 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 23,860 | 40,460 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 39,617 | 34,676 | -4,941 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 34,547 | 34,662 | +115 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 32,300 | 34,326 | +2,026 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 33,535 | +33,535 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 25,044 | +25,044 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 25,975 | 24,316 | -1,659 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 23,862 | +23,862 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 23,202 | 15,796 | -7,406 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 14,991 | +14,991 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,427 | 14,827 | +3,400 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 14,159 | 13,343 | -816 | 0.02 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 0 | 12,391 | +12,391 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,510 | 11,639 | +1,129 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 11,074 | 11,074 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 12,109 | 10,997 | -1,112 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 10,605 | +10,605 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,400 | 10,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| R Squared Ltd | 0 | 10,308 | +10,308 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 11,299 | 10,299 | -1,000 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,703 | 7,646 | -2,057 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 4,055 | 5,732 | +1,677 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,600 | 5,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PURA VIDA INVESTMENTS, LLC | 429,120 | 5,000 | -424,120 | 8.18 | 6.09 | -2.09 | sell |
| HUNTINGTON NATIONAL BANK | 3,820 | 2,487 | -1,333 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,623,536 | 2,399 | -1,621,137 | 0.02 | 0.00 | -0.02 | sell |
| Quantbot Technologies LP | 7,893 | 2,245 | -5,648 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,809 | 1,809 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 333 | 1,584 | +1,251 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,837 | 1,502 | -335 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,754 | 1,467 | -287 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 1,239 | +1,239 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,106 | 1,107 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 309 | 709 | +400 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 605 | 605 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,160 | 500 | -660 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 7,949 | 405 | -7,544 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 786 | 356 | -430 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 211 | +211 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 177 | 177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Accent Capital Management, LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 242 | 144 | -98 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 482 | 72 | -410 | 0.00 | 0.00 | -0.00 | sell |
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | 66 | 66 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Kilter Group LLC | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 1 | 31 | +30 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Fourth Dimension Wealth, LLC | 31 | 31 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADIRONDACK TRUST CO | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Missouri Trust & Investment Co | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 53,266 | 0 | -53,266 | 0.00 | 0.00 | -0.00 | sell |
| GMT CAPITAL CORP | 98,108 | 0 | -98,108 | 0.08 | 0.00 | -0.08 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 25,599 | 0 | -25,599 | 0.03 | 0.00 | -0.03 | sell |