| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 4,579,926 | +4,579,926 | 0.00 | 0.56 | +0.56 | buy |
| Ensign Peak Advisors, Inc | 0 | 2,435,426 | +2,435,426 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 0 | 2,413,000 | +2,413,000 | 0.00 | 0.12 | +0.12 | buy |
| MORGAN STANLEY | 0 | 1,406,425 | +1,406,425 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 72,788 | 1,058,930 | +986,142 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 549,300 | 915,000 | +365,700 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,802,449 | 2,945,424 | +142,975 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 129,084 | +129,084 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17,630 | 127,051 | +109,421 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 402,921 | 502,665 | +99,744 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,427,789 | 2,523,555 | +95,766 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 70,422 | +70,422 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 119,300 | 180,993 | +61,693 | 0.04 | 0.09 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 0 | 52,789 | +52,789 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 40,964 | +40,964 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 38,066 | +38,066 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 767,332 | 805,359 | +38,027 | 0.09 | 0.14 | +0.05 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 29,507 | +29,507 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 29,616 | 47,573 | +17,957 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 14,125 | +14,125 | 0.00 | 0.00 | +0.00 | buy |
| UPTICK PARTNERS, LLC | 0 | 13,800 | +13,800 | 0.00 | 0.01 | +0.01 | buy |
| Total Clarity Wealth Management, Inc. | 0 | 13,681 | +13,681 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,793 | 39,307 | +12,514 | 0.00 | 0.00 | +0.00 | buy |
| 1620 INVESTMENT ADVISORS, INC. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 12,338 | 16,209 | +3,871 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 160,370 | 163,415 | +3,045 | 0.00 | 0.00 | +0.00 | buy |
| OneDigital Investment Advisors LLC | 25,801 | 28,473 | +2,672 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 96,426 | 98,622 | +2,196 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 20,378 | 22,507 | +2,129 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 739 | 2,531 | +1,792 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 3,073,532 | 3,074,372 | +840 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 61,198 | 61,735 | +537 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,473,683 | 3,473,683 | 0 | 0.55 | 0.64 | +0.08 | hold |
| ORBIMED ADVISORS LLC | 7,133,515 | 7,133,515 | 0 | 0.12 | 0.18 | +0.06 | hold |
| Ameritas Investment Partners, Inc. | 10,167 | 10,167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 45,680 | 45,680 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,276,315 | 4,276,315 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 3,545,454 | 3,545,454 | 0 | 0.07 | 0.09 | +0.02 | hold |
| CIBC Private Wealth Group LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GRIMES & COMPANY, INC. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Amundi | 81,305 | 81,305 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LPL Financial LLC | 11,500 | 11,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 3,588,427 | 3,588,427 | 0 | 0.77 | 1.74 | +0.96 | hold |
| NEA Management Company, LLC | 14,986,793 | 14,986,793 | 0 | 0.84 | 1.29 | +0.46 | hold |
| Private Advisor Group, LLC | 21,800 | 21,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vontobel Holding Ltd. | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 650,000 | 650,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 335,000 | 335,000 | 0 | 0.23 | 0.41 | +0.18 | hold |
| Bain Capital Life Sciences Investors, LLC | 16,915,784 | 16,915,784 | 0 | 1.36 | 1.89 | +0.53 | hold |
| LexAurum Advisors, LLC | 16,000 | 16,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Bleichroeder LP | 17,865 | 17,865 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Simplify Asset Management Inc. | 400,000 | 400,000 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Blue Trust, Inc. | 8,520 | 8,520 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Propel Bio Management, LLC | 535,000 | 535,000 | 0 | 0.37 | 0.43 | +0.06 | hold |
| LAZARI CAPITAL MANAGEMENT, INC. | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Pathstone Holdings, LLC | 12,637 | 12,637 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAELIPSKIE PARTNERSHIP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 25,100 | 25,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 55,296 | 55,296 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 30,158 | 30,158 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 11,326 | 11,326 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,551 | 51,551 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 2,100 | 2,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 323,843 | 323,843 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 962 | 0 | -962 | 0.00 | 0.00 | 0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 17,079 | 15,953 | -1,126 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 1,612 | 469 | -1,143 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 16,626 | 13,691 | -2,935 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 90,452 | 86,225 | -4,227 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,265 | 12,593 | -7,672 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,062,985 | 1,054,488 | -8,497 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 49,260 | 40,598 | -8,662 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 14,086 | 4,152 | -9,934 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 345,954 | 335,974 | -9,980 | 0.00 | 0.00 | +0.00 | sell |
| MISSION WEALTH MANAGEMENT, LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| StoneX Group Inc. | 11,751 | 0 | -11,751 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 17,084 | 0 | -17,084 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 47,668 | 20,822 | -26,846 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 31,979 | 0 | -31,979 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 39,400 | 0 | -39,400 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 388,363 | 342,363 | -46,000 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 70,764 | 21,246 | -49,518 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 64,763 | 0 | -64,763 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 69,086 | 0 | -69,086 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 529,601 | 448,708 | -80,893 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 127,718 | 0 | -127,718 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 164,342 | 35,927 | -128,415 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 8,008,865 | 7,827,727 | -181,138 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 181,609 | 0 | -181,609 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 283,544 | 61,575 | -221,969 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,743,038 | 1,335,521 | -407,517 | 0.05 | 0.05 | +0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 945,171 | 321,021 | -624,150 | 0.07 | 0.04 | -0.03 | sell |
| CITADEL ADVISORS LLC | 1,728,065 | 762,854 | -965,211 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,664,317 | 258,759 | -1,405,558 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 1,936,000 | 0 | -1,936,000 | 0.04 | 0.00 | -0.04 | sell |