| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 8,208,015 | 9,466,992 | +1,258,977 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,499,100 | 8,103,400 | -395,700 | 0.00 | 0.00 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 7,967,454 | 7,967,454 | 0 | 2.44 | 2.97 | +0.53 | hold |
| PERCEPTIVE ADVISORS LLC | 6,314,452 | 6,737,648 | +423,196 | 0.46 | 0.55 | +0.09 | buy |
| Saturn V Capital Management LP | 5,800,530 | 6,456,646 | +656,116 | 4.26 | 4.83 | +0.57 | buy |
| Deep Track Capital, LP | 5,013,661 | 6,339,535 | +1,325,874 | 0.46 | 0.54 | +0.08 | buy |
| BRAIDWELL LP | 3,368,904 | 3,272,954 | -95,950 | 0.43 | 0.45 | +0.02 | sell |
| NEA Management Company, LLC | 3,233,743 | 3,233,743 | 0 | 0.66 | 0.76 | +0.10 | hold |
| Rosalind Advisors, Inc. | 2,605,920 | 3,214,766 | +608,846 | 3.80 | 5.44 | +1.64 | buy |
| Blackstone Inc. | 2,681,922 | 2,681,922 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Nantahala Capital Management, LLC | 2,449,468 | 2,449,468 | 0 | 0.58 | 0.63 | +0.05 | hold |
| BVF INC/IL | 2,233,742 | 2,233,742 | 0 | 0.30 | 0.29 | -0.01 | hold |
| Samsara BioCapital, LLC | 1,960,000 | 1,832,566 | -127,434 | 0.81 | 0.74 | -0.07 | sell |
| BlackRock, Inc. | 1,226,808 | 1,211,794 | -15,014 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 55,978 | 1,210,514 | +1,154,536 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,000,855 | 1,001,095 | +240 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 940,447 | 939,726 | -721 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 831,890 | 882,134 | +50,244 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 856,222 | +856,222 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 898,465 | 850,742 | -47,723 | 0.62 | 0.68 | +0.06 | sell |
| STATE STREET CORP | 198,234 | 403,534 | +205,300 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 80,456 | 336,834 | +256,378 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 593,573 | 335,309 | -258,264 | 1.88 | 1.22 | -0.66 | sell |
| VR Adviser, LLC | 0 | 330,525 | +330,525 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 0 | 267,340 | +267,340 | 0.00 | 0.00 | +0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 273,349 | 234,039 | -39,310 | 0.37 | 0.27 | -0.10 | sell |
| Qube Research & Technologies Ltd | 67,747 | 218,954 | +151,207 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 178,235 | 178,235 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pale Fire Capital SE | 167,590 | 167,590 | 0 | 0.09 | 0.06 | -0.03 | hold |
| BANK OF AMERICA CORP /DE/ | 0 | 150,676 | +150,676 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 145,000 | 145,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| Palumbo Wealth Management LLC | 113,357 | 131,014 | +17,657 | 0.11 | 0.13 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 127,321 | +127,321 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 43,259 | 102,599 | +59,340 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,788 | 66,749 | -39 | 0.00 | 0.00 | +0.00 | sell |
| OMERS ADMINISTRATION Corp | 109,200 | 57,300 | -51,900 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 32,239 | 50,287 | +18,048 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 47,383 | +47,383 | 0.00 | 0.03 | +0.03 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 36,221 | +36,221 | 0.00 | 0.06 | +0.06 | buy |
| CITIGROUP INC | 32,332 | 35,765 | +3,433 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 28,973 | +28,973 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 20,496 | 21,789 | +1,293 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 19,968 | +19,968 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 19,514 | +19,514 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 26,118 | 19,474 | -6,644 | 0.00 | 0.00 | +0.00 | sell |
| CAXTON CORP | 15,557 | 15,557 | 0 | 1.45 | 1.60 | +0.14 | hold |
| ExodusPoint Capital Management, LP | 79,072 | 14,703 | -64,369 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 17,246 | 13,868 | -3,378 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 16,427 | 13,819 | -2,608 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 22,489 | 12,730 | -9,759 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 12,317 | +12,317 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,525 | +11,525 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 11,200 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,600 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 511 | 4,756 | +4,245 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 57,500 | 2,814 | -54,686 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 2,754 | 1,996 | -758 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 0 | 1,065 | +1,065 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 802 | +802 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 729 | 729 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 3,998 | 712 | -3,286 | 0.00 | 0.00 | -0.00 | sell |
| Bleichroeder LP | 595 | 595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 331 | 331 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 715 | 310 | -405 | 0.00 | 0.00 | -0.00 | sell |
| Blue Trust, Inc. | 284 | 284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 10,446 | 180 | -10,266 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 0 | 128 | +128 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 50 | 54 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 64,505 | 0 | -64,505 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 128,675 | 0 | -128,675 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 91,413 | 0 | -91,413 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 22,200 | 0 | -22,200 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 808,154 | 0 | -808,154 | 0.01 | 0.00 | -0.01 | sell |
| NewEdge Advisors, LLC | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 24,187 | 0 | -24,187 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 12,518 | 0 | -12,518 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 357,387 | 0 | -357,387 | 0.21 | 0.00 | -0.21 | sell |
| RMG Wealth Management LLC | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 137 | 0 | -137 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 1,500,000 | 0 | -1,500,000 | 0.18 | 0.00 | -0.18 | sell |