| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,473,683 | 4,623,683 | +1,150,000 | 0.64 | 0.41 | -0.22 | buy |
| Velan Capital Investment Management LP | 0 | 659,020 | +659,020 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,945,424 | 3,515,538 | +570,114 | 0.00 | 0.00 | -0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 0 | 489,158 | +489,158 | 0.00 | 0.06 | +0.06 | buy |
| VANGUARD GROUP INC | 7,827,727 | 8,290,050 | +462,323 | 0.00 | 0.00 | -0.00 | buy |
| Diametric Capital, LP | 0 | 448,594 | +448,594 | 0.00 | 0.14 | +0.14 | buy |
| AQR CAPITAL MANAGEMENT LLC | 35,927 | 424,042 | +388,115 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 915,000 | 1,269,693 | +354,693 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,523,555 | 2,763,790 | +240,235 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 227,246 | +227,246 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 163,367 | +163,367 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 21,246 | 164,248 | +143,002 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 38,066 | 177,032 | +138,966 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 335,974 | 469,372 | +133,398 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 323,843 | 438,208 | +114,365 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 111,245 | +111,245 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 2,435,426 | 2,546,458 | +111,032 | 0.01 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 258,759 | 343,416 | +84,657 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 86,225 | 164,267 | +78,042 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 75,405 | +75,405 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 45,680 | 109,570 | +63,890 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 50,537 | +50,537 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 45,000 | 75,000 | +30,000 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 163,415 | 187,246 | +23,831 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 40,598 | 58,702 | +18,104 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 13,691 | 31,410 | +17,719 | 0.00 | 0.00 | -0.00 | buy |
| Allred Capital Management, LLC | 0 | 12,800 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 39,307 | 50,226 | +10,919 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 16,209 | 26,963 | +10,754 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 10,362 | +10,362 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 11,326 | 18,609 | +7,283 | 0.00 | 0.00 | -0.00 | buy |
| Private Advisor Group, LLC | 21,800 | 25,500 | +3,700 | 0.00 | 0.00 | -0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 10,000 | 12,000 | +2,000 | 0.01 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,901 | +1,901 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 3,074,372 | 3,076,077 | +1,705 | 0.01 | 0.01 | -0.01 | buy |
| NORTHERN TRUST CORP | 1,054,488 | 1,056,006 | +1,518 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 805,359 | 806,616 | +1,257 | 0.14 | 0.06 | -0.07 | buy |
| FMR LLC | 2,531 | 3,599 | +1,068 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 7 | 911 | +904 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 503 | +503 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,551 | 51,639 | +88 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 7,133,515 | 7,133,515 | 0 | 0.18 | 0.08 | -0.10 | hold |
| Ameritas Investment Partners, Inc. | 10,167 | 10,167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,276,315 | 4,276,315 | 0 | 0.01 | 0.00 | -0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 3,545,454 | 3,545,454 | 0 | 0.09 | 0.05 | -0.04 | hold |
| CIBC Private Wealth Group LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LPL Financial LLC | 11,500 | 11,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 14,986,793 | 14,986,793 | 0 | 1.29 | 0.65 | -0.64 | hold |
| MetLife Investment Management, LLC | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 335,000 | 335,000 | 0 | 0.41 | 0.24 | -0.17 | hold |
| Bain Capital Life Sciences Investors, LLC | 16,915,784 | 16,915,784 | 0 | 1.89 | 1.08 | -0.81 | hold |
| LexAurum Advisors, LLC | 16,000 | 16,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bleichroeder LP | 17,865 | 17,865 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Blue Trust, Inc. | 8,520 | 8,520 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Knott David M Jr | 180,993 | 180,993 | 0 | 0.09 | 0.04 | -0.05 | hold |
| Frazier Financial Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UPTICK PARTNERS, LLC | 13,800 | 13,800 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Pathstone Holdings, LLC | 12,637 | 12,637 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RAELIPSKIE PARTNERSHIP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 25,100 | 25,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 30,158 | 30,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 2,100 | 2,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 14,125 | 14,125 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 4,152 | 4,152 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 98,622 | 98,580 | -42 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,593 | 12,176 | -417 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 469 | 0 | -469 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 15,953 | 15,204 | -749 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 22,507 | 16,779 | -5,728 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 28,473 | 21,500 | -6,973 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 52,789 | 40,577 | -12,212 | 0.00 | 0.00 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 13,681 | 0 | -13,681 | 0.01 | 0.00 | -0.01 | sell |
| GRIMES & COMPANY, INC. | 15,000 | 0 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 20,822 | 0 | -20,822 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 29,507 | 0 | -29,507 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 40,964 | 0 | -40,964 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 61,575 | 17,085 | -44,490 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 47,573 | 0 | -47,573 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 55,296 | 0 | -55,296 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 61,735 | 0 | -61,735 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 70,422 | 0 | -70,422 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 81,305 | 0 | -81,305 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 127,051 | 36,566 | -90,485 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 650,000 | 543,084 | -106,916 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 129,084 | 0 | -129,084 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,335,521 | 1,160,521 | -175,000 | 0.05 | 0.02 | -0.03 | sell |
| GSA CAPITAL PARTNERS LLP | 321,021 | 0 | -321,021 | 0.04 | 0.00 | -0.04 | sell |
| ROYCE & ASSOCIATES LP | 342,363 | 0 | -342,363 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 448,708 | 93,821 | -354,887 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 400,000 | 0 | -400,000 | 0.05 | 0.00 | -0.05 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 502,665 | 0 | -502,665 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 4,579,926 | 4,051,000 | -528,926 | 0.56 | 0.21 | -0.35 | sell |
| Propel Bio Management, LLC | 535,000 | 0 | -535,000 | 0.43 | 0.00 | -0.43 | sell |
| CITADEL ADVISORS LLC | 762,854 | 0 | -762,854 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,058,930 | 171,190 | -887,740 | 0.00 | 0.00 | -0.00 | sell |