| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1,211,794 | 5,554,906 | +4,343,112 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 330,525 | 1,934,253 | +1,603,728 | 0.05 | 0.27 | +0.22 | buy |
| PERCEPTIVE ADVISORS LLC | 6,737,648 | 7,933,491 | +1,195,843 | 0.55 | 0.58 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 939,726 | 2,098,047 | +1,158,321 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 403,534 | 1,296,017 | +892,483 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 6,456,646 | 6,973,343 | +516,697 | 4.83 | 4.67 | -0.16 | buy |
| NORTHERN TRUST CORP | 178,235 | 652,849 | +474,614 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 263,264 | +263,264 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,103,400 | 8,321,657 | +218,257 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,749 | 263,264 | +196,515 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 196,340 | +196,340 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 107,389 | +107,389 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 95,726 | +95,726 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 95,081 | +95,081 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 78,885 | +78,885 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 19,968 | 96,772 | +76,804 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 76,314 | +76,314 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 74,795 | +74,795 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 67,712 | +67,712 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 67,078 | +67,078 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 66,379 | +66,379 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 51,800 | +51,800 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 47,969 | +47,969 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 41,072 | +41,072 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 37,073 | +37,073 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 882,134 | 916,536 | +34,402 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 35,765 | 70,112 | +34,347 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 33,552 | +33,552 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 23,846 | +23,846 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 22,880 | +22,880 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 22,083 | +22,083 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 12,317 | 34,253 | +21,936 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 18,100 | +18,100 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 17,290 | +17,290 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,814 | 19,439 | +16,625 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 16,500 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 15,838 | +15,838 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,756 | 16,384 | +11,628 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,588 | +10,588 | 0.00 | 0.00 | +0.00 | buy |
| Pettinga Financial Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 0 | 7,858 | +7,858 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 180 | 7,745 | +7,565 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 7,338 | +7,338 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,868 | 19,426 | +5,558 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 10,600 | 14,400 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 1,629 | +1,629 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,113 | +1,113 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 13,819 | 13,872 | +53 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,233,742 | 2,233,742 | 0 | 0.29 | 0.27 | -0.03 | hold |
| CAXTON CORP | 15,557 | 15,557 | 0 | 1.60 | 3.92 | +2.32 | hold |
| Blackstone Inc. | 2,681,922 | 2,681,922 | 0 | 0.05 | 0.04 | -0.00 | hold |
| Nantahala Capital Management, LLC | 2,449,468 | 2,449,468 | 0 | 0.63 | 0.69 | +0.06 | hold |
| NEA Management Company, LLC | 3,233,743 | 3,233,743 | 0 | 0.76 | 0.95 | +0.19 | hold |
| Rosalind Advisors, Inc. | 3,214,766 | 3,214,766 | 0 | 5.44 | 5.64 | +0.20 | hold |
| Bain Capital Life Sciences Investors, LLC | 7,967,454 | 7,967,454 | 0 | 2.97 | 2.21 | -0.76 | hold |
| Rockefeller Capital Management L.P. | 33 | 33 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 145,000 | 145,000 | 0 | 0.04 | 0.03 | -0.00 | hold |
| Bleichroeder LP | 595 | 595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 1,001,095 | 1,001,095 | 0 | 0.02 | 0.01 | -0.00 | hold |
| HighMark Wealth Management LLC | 6 | 6 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blue Trust, Inc. | 284 | 284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 712 | 712 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 54 | 9 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 116 | 0 | -116 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 128 | 0 | -128 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 310 | 0 | -310 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 331 | 0 | -331 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 729 | 0 | -729 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 802 | 0 | -802 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 1,065 | 0 | -1,065 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 1,996 | 0 | -1,996 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 21,789 | 18,519 | -3,270 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 9,466,992 | 9,461,279 | -5,713 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 11,200 | 0 | -11,200 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 11,525 | 0 | -11,525 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 12,730 | 0 | -12,730 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 14,703 | 0 | -14,703 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 102,599 | 87,282 | -15,317 | 0.01 | 0.01 | +0.00 | sell |
| Jefferies Financial Group Inc. | 19,474 | 0 | -19,474 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 19,514 | 0 | -19,514 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 28,973 | 0 | -28,973 | 0.03 | 0.00 | -0.03 | sell |
| Dynamic Technology Lab Private Ltd | 36,221 | 0 | -36,221 | 0.06 | 0.00 | -0.06 | sell |
| Catalyst Funds Management Pty Ltd | 47,383 | 0 | -47,383 | 0.03 | 0.00 | -0.03 | sell |
| Hudson Bay Capital Management LP | 50,287 | 0 | -50,287 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 57,300 | 0 | -57,300 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 131,014 | 67,116 | -63,898 | 0.13 | 0.07 | -0.07 | sell |
| Stonepine Capital Management, LLC | 335,309 | 224,989 | -110,320 | 1.22 | 0.80 | -0.42 | sell |
| Brevan Howard Capital Management LP | 127,321 | 0 | -127,321 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 150,676 | 0 | -150,676 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 167,590 | 0 | -167,590 | 0.06 | 0.00 | -0.06 | sell |
| Qube Research & Technologies Ltd | 218,954 | 0 | -218,954 | 0.00 | 0.00 | -0.00 | sell |
| ACORN CAPITAL ADVISORS, LLC | 234,039 | 0 | -234,039 | 0.27 | 0.00 | -0.27 | sell |
| UBS Group AG | 267,340 | 0 | -267,340 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 336,834 | 0 | -336,834 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,272,954 | 2,922,754 | -350,200 | 0.45 | 0.50 | +0.05 | sell |
| Samsara BioCapital, LLC | 1,832,566 | 1,395,587 | -436,979 | 0.74 | 0.54 | -0.20 | sell |