| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Pale Fire Capital SE | 177,032 | 1,602,792 | +1,425,760 | 0.01 | 0.17 | +0.16 | buy |
| Schonfeld Strategic Advisors LLC | 1,269,693 | 1,920,800 | +651,107 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 507,694 | +507,694 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,160,521 | 1,549,358 | +388,837 | 0.02 | 0.03 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 424,042 | 715,722 | +291,680 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,056,006 | 1,319,599 | +263,593 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 261,126 | +261,126 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,763,790 | 2,952,895 | +189,105 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 93,821 | 277,682 | +183,861 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 8,290,050 | 8,440,730 | +150,680 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 171,190 | 292,585 | +121,395 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 36,566 | 125,080 | +88,514 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 543,084 | 625,052 | +81,968 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 81,305 | +81,305 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 55,004 | +55,004 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 16,779 | 63,506 | +46,727 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 111,245 | 157,642 | +46,397 | 0.01 | 0.01 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 45,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 44,355 | +44,355 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 38,400 | +38,400 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 63,453 | 92,266 | +28,813 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 98,580 | 123,780 | +25,200 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,085 | 40,710 | +23,625 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 343,416 | 363,208 | +19,792 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 4,623,683 | 4,638,683 | +15,000 | 0.41 | 0.46 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 806,616 | 818,727 | +12,111 | 0.06 | 0.07 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,093 | +12,093 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 911 | 12,639 | +11,728 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,599 | 11,142 | +7,543 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 14,125 | 20,092 | +5,967 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,226 | 55,996 | +5,770 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 25,500 | 28,500 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 12,000 | 13,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 3,076,077 | 3,076,941 | +864 | 0.01 | 0.01 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 760 | +760 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 486 | +486 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 49 | 314 | +265 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 25,100 | 25,250 | +150 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 7,133,515 | 7,133,515 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 10,167 | 10,167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 58,702 | 58,702 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,176 | 12,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 109,570 | 109,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,276,315 | 4,276,315 | 0 | 0.00 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 3,545,454 | 3,545,454 | 0 | 0.05 | 0.05 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 2,546,458 | 2,546,458 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 14,986,793 | 14,986,793 | 0 | 0.65 | 0.55 | -0.11 | hold |
| Arax Advisory Partners | 503 | 503 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vontobel Holding Ltd. | 75,000 | 75,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 335,000 | 335,000 | 0 | 0.24 | 0.23 | -0.01 | hold |
| Bain Capital Life Sciences Investors, LLC | 16,915,784 | 16,915,784 | 0 | 1.08 | 1.18 | +0.10 | hold |
| LexAurum Advisors, LLC | 16,000 | 16,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bleichroeder LP | 17,865 | 17,865 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 180 | 180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Trust, Inc. | 8,520 | 8,520 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Financial Advisors, LLC | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 12,637 | 12,637 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAELIPSKIE PARTNERSHIP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 30,158 | 30,158 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 18,609 | 18,609 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,639 | 51,639 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 438,208 | 438,208 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 4,152 | 4,152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 40,577 | 40,577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Headlands Technologies LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 15,204 | 14,927 | -277 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 90,404 | 89,850 | -554 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 1,901 | 0 | -1,901 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 4,000 | 2,000 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 2,100 | 100 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 187,246 | 178,478 | -8,768 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 10,362 | 0 | -10,362 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 11,500 | 0 | -11,500 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 31,410 | 18,746 | -12,664 | 0.00 | 0.00 | -0.00 | sell |
| Allred Capital Management, LLC | 12,800 | 0 | -12,800 | 0.00 | 0.00 | -0.00 | sell |
| UPTICK PARTNERS, LLC | 13,800 | 0 | -13,800 | 0.01 | 0.00 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 26,963 | 10,776 | -16,187 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 21,500 | 0 | -21,500 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 180,993 | 154,071 | -26,922 | 0.04 | 0.04 | -0.01 | sell |
| GROUP ONE TRADING LLC | 164,248 | 125,504 | -38,744 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 164,267 | 122,448 | -41,819 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 50,537 | 0 | -50,537 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 163,367 | 105,083 | -58,284 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,515,538 | 3,447,512 | -68,026 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 75,405 | 3,455 | -71,950 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 469,372 | 344,747 | -124,625 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 448,594 | 288,552 | -160,042 | 0.14 | 0.10 | -0.05 | sell |
| Hudson Bay Capital Management LP | 227,246 | 0 | -227,246 | 0.00 | 0.00 | -0.00 | sell |
| K2 PRINCIPAL FUND, L.P. | 489,158 | 89,158 | -400,000 | 0.06 | 0.01 | -0.05 | sell |
| Velan Capital Investment Management LP | 659,020 | 0 | -659,020 | 0.22 | 0.00 | -0.22 | sell |
| Sio Capital Management, LLC | 2,499,800 | 1,303,508 | -1,196,292 | 0.55 | 0.39 | -0.16 | sell |
| Soleus Capital Management, L.P. | 4,051,000 | 0 | -4,051,000 | 0.21 | 0.00 | -0.21 | sell |