| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 2,233,742 | +2,233,742 | 0.00 | 0.31 | +0.31 | buy |
| Nantahala Capital Management, LLC | 0 | 2,228,350 | +2,228,350 | 0.00 | 0.47 | +0.47 | buy |
| Bain Capital Life Sciences Investors, LLC | 563,859 | 2,436,588 | +1,872,729 | 0.13 | 0.55 | +0.42 | buy |
| NEA Management Company, LLC | 499,559 | 2,233,743 | +1,734,184 | 0.07 | 0.42 | +0.35 | buy |
| Rosalind Advisors, Inc. | 0 | 1,544,607 | +1,544,607 | 0.00 | 1.87 | +1.87 | buy |
| Deep Track Capital, LP | 0 | 1,122,484 | +1,122,484 | 0.00 | 0.11 | +0.11 | buy |
| Stonepine Capital Management, LLC | 0 | 1,056,338 | +1,056,338 | 0.00 | 2.94 | +2.94 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 233,332 | 933,332 | +700,000 | 0.09 | 0.50 | +0.41 | buy |
| STEMPOINT CAPITAL LP | 0 | 555,411 | +555,411 | 0.00 | 0.38 | +0.38 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 343,963 | +343,963 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 231,892 | 410,485 | +178,593 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 159,835 | +159,835 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 60,051 | 180,851 | +120,800 | 0.01 | 0.07 | +0.06 | buy |
| ACORN CAPITAL ADVISORS, LLC | 153,730 | 273,349 | +119,619 | 0.19 | 0.47 | +0.28 | buy |
| Palumbo Wealth Management LLC | 0 | 95,327 | +95,327 | 0.00 | 0.10 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 49,146 | 79,658 | +30,512 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 15,534 | 38,734 | +23,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,868 | +13,868 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,203 | 10,679 | +5,476 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 2,914 | +2,914 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 17,366 | 19,177 | +1,811 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 2,166 | 2,166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bleichroeder LP | 595 | 595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 216 | 216 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Trust, Inc. | 284 | 284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 3,998 | 3,998 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 21,667 | 21,666 | -1 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 38 | 0 | -38 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 64 | 0 | -64 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 636 | 554 | -82 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 139 | 0 | -139 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 149 | 0 | -149 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 762 | 32 | -730 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 1,120 | 0 | -1,120 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,697 | 0 | -1,697 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,414 | 0 | -2,414 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 9,727 | 729 | -8,998 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 10,548 | 0 | -10,548 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 11,261 | 0 | -11,261 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 12,587 | 0 | -12,587 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 78,061 | 64,795 | -13,266 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 18,864 | 0 | -18,864 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 26,382 | 0 | -26,382 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 38,982 | 0 | -38,982 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 80,000 | 0 | -80,000 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 97,344 | 0 | -97,344 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 179,228 | 61,934 | -117,294 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 132,724 | 0 | -132,724 | 0.02 | 0.00 | -0.02 | sell |