| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,973,683 | 3,473,683 | +1,500,000 | 0.39 | 0.55 | +0.16 | buy |
| Sio Capital Management, LLC | 2,599,003 | 3,588,427 | +989,424 | 0.88 | 0.77 | -0.10 | buy |
| Bain Capital Life Sciences Investors, LLC | 15,960,588 | 16,915,784 | +955,196 | 1.95 | 1.36 | -0.59 | buy |
| GSA CAPITAL PARTNERS LLP | 621,587 | 945,171 | +323,584 | 0.06 | 0.07 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,207 | 402,921 | +297,714 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 119,006 | 388,363 | +269,357 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 46,645 | 283,544 | +236,899 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 7,824,717 | 8,008,865 | +184,148 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,559,986 | 1,743,038 | +183,052 | 0.03 | 0.05 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 181,609 | +181,609 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,642,915 | 2,802,449 | +159,534 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 382,134 | 529,601 | +147,467 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 127,718 | +127,718 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 0 | 119,300 | +119,300 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 61,289 | 164,342 | +103,053 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 81,305 | +81,305 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 69,086 | +69,086 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 64,763 | +64,763 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,378,626 | 2,427,789 | +49,163 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 39,400 | +39,400 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 31,979 | +31,979 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 29,616 | +29,616 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 49,593 | 72,788 | +23,195 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 68 | 17,630 | +17,562 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 17,084 | +17,084 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 81,029 | 96,426 | +15,397 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 34,340 | 47,668 | +13,328 | 0.00 | 0.00 | -0.00 | buy |
| StoneX Group Inc. | 0 | 11,751 | +11,751 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 80,278 | 90,452 | +10,174 | 0.00 | 0.00 | -0.00 | buy |
| MISSION WEALTH MANAGEMENT, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,995 | 20,378 | +4,383 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 13,731 | 17,079 | +3,348 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,277 | 12,338 | +2,061 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 10,500 | 11,500 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 16,327 | 16,626 | +299 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 7,133,515 | 7,133,515 | 0 | 0.17 | 0.12 | -0.05 | hold |
| Ameritas Investment Partners, Inc. | 10,167 | 10,167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 49,260 | 49,260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 45,680 | 45,680 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 160,370 | 160,370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,276,315 | 4,276,315 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 3,545,454 | 3,545,454 | 0 | 0.13 | 0.07 | -0.06 | hold |
| CIBC Private Wealth Group LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GRIMES & COMPANY, INC. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 14,986,793 | 14,986,793 | 0 | 1.26 | 0.84 | -0.42 | hold |
| Private Advisor Group, LLC | 21,800 | 21,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vontobel Holding Ltd. | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 650,000 | 650,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 335,000 | 335,000 | 0 | 0.47 | 0.23 | -0.24 | hold |
| LexAurum Advisors, LLC | 16,000 | 16,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bleichroeder LP | 17,865 | 17,865 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Simplify Asset Management Inc. | 400,000 | 400,000 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Blue Trust, Inc. | 8,520 | 8,520 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 55,296 | 55,296 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 11,326 | 11,326 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,793 | 26,793 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 2,100 | 2,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 323,843 | 323,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 30,350 | 30,158 | -192 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 61,445 | 61,198 | -247 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,968 | 51,551 | -417 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,576 | 739 | -837 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,456 | 1,612 | -844 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 15,321 | 14,086 | -1,235 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,750 | 25,100 | -1,650 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 30,315 | 25,801 | -4,514 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,067,693 | 1,062,985 | -4,708 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 6,779 | 0 | -6,779 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,167 | 20,265 | -6,902 | 0.00 | 0.00 | -0.00 | sell |
| Total Clarity Wealth Management, Inc. | 11,532 | 0 | -11,532 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 13,280 | 962 | -12,318 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 12,890 | 0 | -12,890 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 13,367 | 0 | -13,367 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 14,746 | 0 | -14,746 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 32,337 | 0 | -32,337 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 800,000 | 767,332 | -32,668 | 0.16 | 0.09 | -0.07 | sell |
| Schonfeld Strategic Advisors LLC | 586,042 | 549,300 | -36,742 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,592 | 0 | -51,592 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 61,227 | 0 | -61,227 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 65,421 | 0 | -65,421 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,798,628 | 1,728,065 | -70,563 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 3,147,865 | 3,073,532 | -74,333 | 0.01 | 0.01 | -0.00 | sell |
| Verition Fund Management LLC | 88,395 | 0 | -88,395 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 474,693 | 345,954 | -128,739 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 142,731 | 0 | -142,731 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 226,361 | 70,764 | -155,597 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 373,193 | 0 | -373,193 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 2,356,000 | 1,936,000 | -420,000 | 0.08 | 0.04 | -0.03 | sell |
| Monashee Investment Management LLC | 427,265 | 0 | -427,265 | 0.19 | 0.00 | -0.19 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,615,964 | 1,664,317 | -1,951,647 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 5,273,685 | 0 | -5,273,685 | 1.91 | 0.00 | -1.91 | sell |
| Tri Locum Partners LP | 6,247,500 | 0 | -6,247,500 | 2.19 | 0.00 | -2.19 | sell |
| Polar Capital Holdings Plc | 7,500,000 | 0 | -7,500,000 | 0.06 | 0.00 | -0.06 | sell |