| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 8,499,100 | +8,499,100 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 8,208,015 | +8,208,015 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 6,314,452 | +6,314,452 | 0.00 | 0.46 | +0.46 | buy |
| Saturn V Capital Management LP | 0 | 5,800,530 | +5,800,530 | 0.00 | 4.26 | +4.26 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,436,588 | 7,967,454 | +5,530,866 | 0.55 | 2.44 | +1.89 | buy |
| Deep Track Capital, LP | 1,122,484 | 5,013,661 | +3,891,177 | 0.11 | 0.46 | +0.35 | buy |
| BRAIDWELL LP | 0 | 3,368,904 | +3,368,904 | 0.00 | 0.43 | +0.43 | buy |
| VANGUARD GROUP INC | 410,485 | 3,423,662 | +3,013,177 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 2,681,922 | +2,681,922 | 0.00 | 0.05 | +0.05 | buy |
| Samsara BioCapital, LLC | 0 | 1,960,000 | +1,960,000 | 0.00 | 0.81 | +0.81 | buy |
| Siren, L.L.C. | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.18 | +0.18 | buy |
| BlackRock, Inc. | 61,934 | 1,226,808 | +1,164,874 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 1,544,607 | 2,605,920 | +1,061,313 | 1.87 | 3.80 | +1.93 | buy |
| Woodline Partners LP | 0 | 1,000,855 | +1,000,855 | 0.00 | 0.02 | +0.02 | buy |
| NEA Management Company, LLC | 2,233,743 | 3,233,743 | +1,000,000 | 0.42 | 0.66 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 79,658 | 940,447 | +860,789 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 831,890 | +831,890 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 21,666 | 808,154 | +786,488 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 357,387 | +357,387 | 0.00 | 0.21 | +0.21 | buy |
| STEMPOINT CAPITAL LP | 555,411 | 898,465 | +343,054 | 0.38 | 0.62 | +0.23 | buy |
| Nantahala Capital Management, LLC | 2,228,350 | 2,449,468 | +221,118 | 0.47 | 0.58 | +0.11 | buy |
| NORTHERN TRUST CORP | 0 | 178,235 | +178,235 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 38,734 | 198,234 | +159,500 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 145,000 | +145,000 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 0 | 128,675 | +128,675 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 109,200 | +109,200 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 91,413 | +91,413 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 80,456 | +80,456 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 79,072 | +79,072 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 67,747 | +67,747 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 66,788 | +66,788 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 64,505 | +64,505 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 57,500 | +57,500 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 43,259 | +43,259 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 32 | 32,332 | +32,300 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 32,239 | +32,239 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 26,118 | +26,118 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 24,187 | +24,187 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 22,489 | +22,489 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 22,200 | +22,200 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 20,496 | +20,496 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 95,327 | 113,357 | +18,030 | 0.10 | 0.11 | +0.01 | buy |
| Creative Planning | 0 | 16,427 | +16,427 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 0 | 15,557 | +15,557 | 0.00 | 1.45 | +1.45 | buy |
| Squarepoint Ops LLC | 0 | 12,518 | +12,518 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,868 | 17,246 | +3,378 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 2,754 | +2,754 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 715 | +715 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 331 | +331 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 137 | +137 | 0.00 | 0.00 | +0.00 | buy |
| RMG Wealth Management LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,233,742 | 2,233,742 | 0 | 0.31 | 0.30 | -0.01 | hold |
| CIBC Private Wealth Group LLC | 2,166 | 2,166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 33 | 33 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 729 | 729 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 33 | 33 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bleichroeder LP | 595 | 595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 6 | 6 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Trust, Inc. | 284 | 284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACORN CAPITAL ADVISORS, LLC | 273,349 | 273,349 | 0 | 0.47 | 0.37 | -0.10 | hold |
| GROUP ONE TRADING LLC | 3,998 | 3,998 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 554 | 511 | -43 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 216 | 50 | -166 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,679 | 10,446 | -233 | 0.00 | 0.00 | +0.00 | sell |
| TD Waterhouse Canada Inc. | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 64,795 | 55,978 | -8,817 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 180,851 | 167,590 | -13,261 | 0.07 | 0.09 | +0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 19,177 | 0 | -19,177 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 159,835 | 0 | -159,835 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 343,963 | 0 | -343,963 | 0.03 | 0.00 | -0.03 | sell |
| Stonepine Capital Management, LLC | 1,056,338 | 593,573 | -462,765 | 2.94 | 1.88 | -1.06 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 933,332 | 0 | -933,332 | 0.50 | 0.00 | -0.50 | sell |