| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 6,922,870 | 6,922,870 | 0 | 65.48 | 100.00 | +34.52 | hold |
| Frazier Life Sciences Management, L.P. | 5,100,000 | 5,100,000 | 0 | 0.75 | 0.88 | +0.13 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,125 | 4,881,125 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Long Focus Capital Management, LLC | 4,619,582 | 4,619,582 | 0 | 1.25 | 1.36 | +0.10 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,372,884 | 4,372,884 | 0 | 0.59 | 0.79 | +0.20 | hold |
| BlackRock, Inc. | 3,560,424 | 3,586,640 | +26,216 | 0.00 | 0.00 | +0.00 | buy |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 3,039,892 | 0 | 1.98 | 2.07 | +0.09 | hold |
| Nantahala Capital Management, LLC | 2,117,697 | 2,117,697 | 0 | 0.69 | 0.88 | +0.20 | hold |
| FRANKLIN RESOURCES INC | 2,198,423 | 2,072,726 | -125,697 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,255,450 | 1,310,862 | +55,412 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 617,338 | 1,097,627 | +480,289 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 926,534 | 964,670 | +38,136 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 1,035,586 | 941,400 | -94,186 | 0.49 | 0.48 | -0.01 | sell |
| B Group, Inc. | 572,576 | 597,576 | +25,000 | 2.31 | 2.96 | +0.65 | buy |
| ACORN CAPITAL ADVISORS, LLC | 595,744 | 595,744 | 0 | 1.10 | 1.13 | +0.03 | hold |
| DIMENSIONAL FUND ADVISORS LP | 517,916 | 558,158 | +40,242 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 557,654 | +557,654 | 0.00 | 0.01 | +0.01 | buy |
| Regency Capital Management Inc.\DE | 538,584 | 532,495 | -6,089 | 1.22 | 1.59 | +0.37 | sell |
| NORTHERN TRUST CORP | 412,809 | 430,522 | +17,713 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 442,789 | 415,191 | -27,598 | 0.00 | 0.00 | +0.00 | sell |
| Caligan Partners LP | 0 | 229,864 | +229,864 | 0.00 | 0.11 | +0.11 | buy |
| MORGAN STANLEY | 0 | 224,041 | +224,041 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 139,926 | 178,726 | +38,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 140,959 | 127,543 | -13,416 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 165,185 | 125,356 | -39,829 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 171,639 | 118,904 | -52,735 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111,865 | 111,865 | 0 | 0.14 | 0.19 | +0.05 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 145,200 | 102,100 | -43,100 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 107,923 | 99,433 | -8,490 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,063 | 97,139 | -37,924 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 36,381 | 91,075 | +54,694 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 114,609 | 90,055 | -24,554 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 60,811 | 89,521 | +28,710 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 83,508 | +83,508 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 72,334 | 72,712 | +378 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 65,034 | 64,720 | -314 | 0.00 | 0.00 | +0.00 | sell |
| Permanent Capital Management, LP | 75,864 | 62,369 | -13,495 | 0.08 | 0.07 | -0.01 | sell |
| TBH Global Asset Management, LLC | 60,322 | 60,322 | 0 | 0.05 | 0.08 | +0.03 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,239 | 57,419 | -1,820 | 0.00 | 0.00 | +0.00 | sell |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 40,744 | 48,323 | +7,579 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,862 | 46,143 | +32,281 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 42,842 | 42,269 | -573 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 41,660 | 41,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 40,502 | 40,502 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 30,828 | 37,971 | +7,143 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 27,282 | 34,268 | +6,986 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,284 | 30,284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 29,746 | +29,746 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 36,090 | 28,729 | -7,361 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 28,300 | 28,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 18,700 | 27,000 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 26,300 | 26,300 | 0 | 0.06 | 0.05 | -0.00 | hold |
| MetLife Investment Management, LLC | 25,031 | 24,962 | -69 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 23,119 | 23,535 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 54,692 | 21,708 | -32,984 | 0.00 | 0.00 | -0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 18,984 | 21,704 | +2,720 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 42,998 | 20,998 | -22,000 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,359 | 20,869 | +510 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 20,402 | +20,402 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 51,419 | 17,955 | -33,464 | 0.00 | 0.00 | -0.00 | sell |
| Inscription Capital, LLC | 0 | 17,806 | +17,806 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 49,053 | 16,994 | -32,059 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,276 | 16,276 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 20,993 | 15,781 | -5,212 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,294 | 14,073 | +2,779 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 13,400 | 13,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 13,274 | +13,274 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,104 | 13,104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,000 | 13,000 | -37,000 | 0.02 | 0.01 | -0.01 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,724 | 12,920 | +1,196 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 34,891 | 12,482 | -22,409 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 69,298 | 11,540 | -57,758 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 11,397 | 11,397 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,348 | 11,269 | +921 | 0.00 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,667 | +10,667 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,634 | 8,430 | +5,796 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 2,459 | 5,665 | +3,206 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,544 | 4,544 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,593 | 4,517 | +2,924 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,342 | 4,096 | -246 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 811 | 4,018 | +3,207 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,955 | 3,913 | +1,958 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 3,736 | 3,675 | -61 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,086 | 3,312 | +226 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,138 | 2,894 | -5,244 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 164 | 2,869 | +2,705 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,704 | 2,377 | -327 | 0.00 | 0.00 | +0.00 | sell |
| Smartleaf Asset Management LLC | 1,741 | 1,790 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 793 | 1,461 | +668 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,247 | 1,416 | +169 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,806 | 1,121 | -685 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 269 | 1,022 | +753 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 41 | 860 | +819 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 113 | 745 | +632 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 346 | 522 | +176 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 488 | +488 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 584 | 392 | -192 | 0.00 | 0.00 | +0.00 | sell |
| IFP Advisors, Inc | 363 | 195 | -168 | 0.00 | 0.00 | -0.00 | sell |