| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 6,922,870 | 6,922,870 | 0 | 11.68 | 19.45 | +7.77 | hold |
| Frazier Life Sciences Management, L.P. | 0 | 5,100,000 | +5,100,000 | 0.00 | 1.28 | +1.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,125 | 4,881,125 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Long Focus Capital Management, LLC | 3,319,582 | 4,619,582 | +1,300,000 | 1.32 | 1.87 | +0.55 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,731,886 | 4,372,884 | +1,640,998 | 0.65 | 1.03 | +0.38 | buy |
| BlackRock, Inc. | 3,539,948 | 3,102,524 | -437,424 | 0.00 | 0.00 | -0.00 | sell |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 3,039,892 | 0 | 4.07 | 4.45 | +0.38 | hold |
| VANGUARD GROUP INC | 1,952,333 | 2,477,502 | +525,169 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,210,589 | 2,340,810 | +130,221 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,267,697 | 2,117,697 | +850,000 | 0.61 | 0.94 | +0.32 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 1,360,768 | 1,495,560 | +134,792 | 0.85 | 0.92 | +0.07 | buy |
| Samsara BioCapital, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 1.28 | +1.28 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,025,556 | 929,974 | -95,582 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 753,158 | 891,028 | +137,870 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 793,011 | 856,186 | +63,175 | 0.00 | 0.00 | +0.00 | buy |
| Regency Capital Management Inc.\DE | 749,482 | 665,881 | -83,601 | 2.62 | 2.19 | -0.44 | sell |
| ACORN CAPITAL ADVISORS, LLC | 590,508 | 595,744 | +5,236 | 0.97 | 2.44 | +1.47 | buy |
| B Group, Inc. | 472,576 | 572,576 | +100,000 | 2.41 | 3.10 | +0.69 | buy |
| Decheng Capital LLC | 515,555 | 515,555 | 0 | 0.85 | 0.82 | -0.03 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 519,785 | 504,828 | -14,957 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 405,926 | 456,157 | +50,231 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 374,518 | 370,472 | -4,046 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 121,644 | 212,298 | +90,654 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 0 | 200,000 | +200,000 | 0.00 | 0.24 | +0.24 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 138,952 | 189,485 | +50,533 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 162,358 | 135,402 | -26,956 | 0.06 | 0.06 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 103,300 | 131,548 | +28,248 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 124,059 | +124,059 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,466 | 119,651 | -18,815 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 107,051 | 93,281 | -13,770 | 0.00 | 0.00 | -0.00 | sell |
| Resolute Capital Asset Partners LLC | 0 | 91,006 | +91,006 | 0.00 | 0.30 | +0.30 | buy |
| AMERIPRISE FINANCIAL INC | 64,493 | 84,558 | +20,065 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 95,706 | 72,334 | -23,372 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 69,030 | 69,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 50,395 | 68,551 | +18,156 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 64,038 | 65,407 | +1,369 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 62,389 | 60,571 | -1,818 | 0.00 | 0.00 | -0.00 | sell |
| TBH Global Asset Management, LLC | 60,322 | 60,322 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 56,798 | +56,798 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 56,529 | +56,529 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,384 | 52,594 | -4,790 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 51,657 | 47,049 | -4,608 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 43,550 | +43,550 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 23,820 | 41,660 | +17,840 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 38,632 | +38,632 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 25,741 | 32,739 | +6,998 | 0.01 | 0.01 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,278 | 30,957 | +679 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 0 | 30,309 | +30,309 | 0.00 | 0.00 | +0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 0 | 30,239 | +30,239 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 27,337 | 27,337 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 28,239 | 22,749 | -5,490 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 0 | 21,872 | +21,872 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 26,123 | 21,864 | -4,259 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 21,200 | 21,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 25,739 | 20,585 | -5,154 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,738 | 20,520 | -7,218 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,635 | +17,635 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 16,276 | +16,276 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 32,865 | 14,009 | -18,856 | 0.00 | 0.00 | -0.00 | sell |
| Ascent Group, LLC | 21,188 | 13,964 | -7,224 | 0.01 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,582 | 13,582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 3,492 | 13,499 | +10,007 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,104 | 13,104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,019 | 12,453 | +2,434 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 0 | 12,218 | +12,218 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 15,437 | 11,853 | -3,584 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 11,397 | 11,397 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 12,293 | 10,003 | -2,290 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,268 | 6,372 | +2,104 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,544 | 4,544 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,011 | 3,686 | -325 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,361 | 3,361 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,656 | 2,395 | +739 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,601 | 1,601 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 29,644 | 1,542 | -28,102 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,279 | 1,279 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 771 | 1,256 | +485 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 1,047 | +1,047 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 863 | +863 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 651 | 834 | +183 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 800 | 714 | -86 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 1,294 | 659 | -635 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 334 | 634 | +300 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,662 | 605 | -1,057 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 48 | 308 | +260 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 295 | +295 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 66 | 261 | +195 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 367 | 241 | -126 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 165 | 165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parkside Financial Bank & Trust | 0 | 164 | +164 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 70 | 75 | +5 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 160 | 36 | -124 | 0.00 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 31 | 31 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Covestor Ltd | 0 | 26 | +26 | 0.00 | 0.00 | 0.00 | buy |
| CIBC WORLD MARKETS CORP | 10,292 | 0 | -10,292 | 0.00 | 0.00 | -0.00 | sell |