| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 9,533,333 | +9,533,333 | 0.00 | 1.63 | +1.63 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,372,884 | 7,206,217 | +2,833,333 | 0.79 | 1.08 | +0.28 | buy |
| Frazier Life Sciences Management, L.P. | 5,100,000 | 7,100,000 | +2,000,000 | 0.88 | 1.10 | +0.22 | buy |
| Long Focus Capital Management, LLC | 4,619,582 | 5,119,582 | +500,000 | 1.36 | 1.48 | +0.13 | buy |
| BlackRock, Inc. | 3,586,640 | 4,707,674 | +1,121,034 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,125 | 4,640,000 | -241,125 | 0.05 | 0.05 | -0.00 | sell |
| Caligan Partners LP | 229,864 | 4,298,248 | +4,068,384 | 0.11 | 1.47 | +1.36 | buy |
| FCPM III SERVICES B.V. | 0 | 4,053,775 | +4,053,775 | 0.00 | 3.84 | +3.84 | buy |
| ORBIMED ADVISORS LLC | 0 | 3,333,333 | +3,333,333 | 0.00 | 0.45 | +0.45 | buy |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 3,039,892 | 0 | 2.07 | 12.16 | +10.09 | hold |
| Nantahala Capital Management, LLC | 2,117,697 | 2,951,030 | +833,333 | 0.88 | 1.27 | +0.38 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.15 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 557,654 | 2,354,619 | +1,796,965 | 0.01 | 0.03 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 2,072,726 | 2,072,726 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,310,862 | 1,754,721 | +443,859 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 1,666,667 | +1,666,667 | 0.00 | 0.79 | +0.79 | buy |
| EcoR1 Capital, LLC | 0 | 1,666,667 | +1,666,667 | 0.00 | 0.59 | +0.59 | buy |
| Foresite Capital Management VI LLC | 0 | 1,333,334 | +1,333,334 | 0.00 | 1.47 | +1.47 | buy |
| STATE STREET CORP | 964,670 | 1,222,984 | +258,314 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 1,210,183 | +1,210,183 | 0.00 | 0.03 | +0.03 | buy |
| Bellevue Group AG | 0 | 1,166,667 | +1,166,667 | 0.00 | 0.17 | +0.17 | buy |
| Vivo Capital, LLC | 0 | 1,166,667 | +1,166,667 | 0.00 | 0.76 | +0.76 | buy |
| ACORN CAPITAL ADVISORS, LLC | 595,744 | 929,077 | +333,333 | 1.13 | 1.80 | +0.67 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,402 | 906,356 | +885,954 | 0.00 | 0.12 | +0.12 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 941,400 | 838,067 | -103,333 | 0.48 | 0.40 | -0.08 | sell |
| B Group, Inc. | 597,576 | 764,243 | +166,667 | 2.96 | 3.08 | +0.12 | buy |
| STEMPOINT CAPITAL LP | 0 | 714,280 | +714,280 | 0.00 | 0.88 | +0.88 | buy |
| DIMENSIONAL FUND ADVISORS LP | 558,158 | 618,891 | +60,733 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,097,627 | 617,467 | -480,160 | 0.01 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 0 | 591,285 | +591,285 | 0.00 | 0.36 | +0.36 | buy |
| NORTHERN TRUST CORP | 430,522 | 549,462 | +118,940 | 0.00 | 0.00 | +0.00 | buy |
| Regency Capital Management Inc.\DE | 532,495 | 540,395 | +7,900 | 1.59 | 1.53 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 178,726 | 464,668 | +285,942 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 415,191 | 278,471 | -136,720 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,894 | 255,331 | +252,437 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 102,100 | 174,200 | +72,100 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 170,000 | +170,000 | 0.00 | 0.05 | +0.05 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 163,156 | +163,156 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97,139 | 163,156 | +66,017 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 89,521 | 149,931 | +60,410 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,543 | 132,122 | +4,579 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 91,075 | 130,656 | +39,581 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 130,152 | +130,152 | 0.00 | 0.04 | +0.04 | buy |
| Bank of New York Mellon Corp | 99,433 | 118,593 | +19,160 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111,865 | 111,865 | 0 | 0.19 | 0.20 | +0.01 | hold |
| AQR CAPITAL MANAGEMENT LLC | 46,143 | 109,889 | +63,746 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 109,564 | +109,564 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 90,055 | 106,351 | +16,296 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 125,356 | 87,162 | -38,194 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 72,712 | 83,804 | +11,092 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 83,508 | 83,508 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 73,000 | +73,000 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 71,258 | +71,258 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 67,405 | +67,405 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 64,720 | 63,657 | -1,063 | 0.00 | 0.00 | -0.00 | sell |
| Permanent Capital Management, LP | 62,369 | 62,369 | 0 | 0.07 | 0.06 | -0.01 | hold |
| TBH Global Asset Management, LLC | 60,322 | 60,322 | 0 | 0.08 | 0.08 | -0.00 | hold |
| WATER ISLAND CAPITAL LLC | 0 | 60,000 | +60,000 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,660 | 52,760 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 51,902 | +51,902 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 51,045 | +51,045 | 0.00 | 0.08 | +0.08 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 49,050 | +49,050 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 34,268 | 44,850 | +10,582 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 42,269 | 42,682 | +413 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 37,971 | 41,844 | +3,873 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,994 | 40,918 | +23,924 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 40,768 | +40,768 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,419 | 36,038 | -21,381 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,284 | 30,316 | +32 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 10,667 | 29,872 | +19,205 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 28,300 | 28,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 23,535 | 27,382 | +3,847 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 27,000 | 27,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 24,962 | 25,220 | +258 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,269 | 24,554 | +13,285 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 12,482 | 23,432 | +10,950 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 22,233 | +22,233 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 20,798 | +20,798 | 0.00 | 0.23 | +0.23 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,869 | 20,663 | -206 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 40,502 | 19,996 | -20,506 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 3,675 | 17,990 | +14,315 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 12,920 | 17,940 | +5,020 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 21,708 | 17,864 | -3,844 | 0.00 | 0.00 | -0.00 | sell |
| Inscription Capital, LLC | 17,806 | 17,806 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Creative Planning | 14,073 | 15,472 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,540 | 14,462 | +2,922 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 13,400 | 13,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ExodusPoint Capital Management, LP | 17,955 | 13,278 | -4,677 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,104 | 13,104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,000 | 13,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 15,781 | 11,521 | -4,260 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 11,440 | +11,440 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,397 | 11,397 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vontobel Holding Ltd. | 15,000 | 11,000 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (US) LLC | 0 | 10,284 | +10,284 | 0.00 | 0.01 | +0.01 | buy |
| Focus Partners Wealth | 0 | 10,049 | +10,049 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 10,006 | +10,006 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 7,653 | +7,653 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,913 | 6,952 | +3,039 | 0.00 | 0.00 | +0.00 | buy |