| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 3,024,905 | 5,802,682 | +2,777,777 | 0.49 | 0.84 | +0.35 | buy |
| Matrix Capital Management Company, LP | 5,362,870 | 6,922,870 | +1,560,000 | 0.58 | 0.63 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,875,000 | 4,225,000 | +1,350,000 | 0.06 | 0.08 | +0.02 | buy |
| CITADEL ADVISORS LLC | 2,484,067 | 3,631,294 | +1,147,227 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 1,031,094 | 1,730,431 | +699,337 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 600,118 | +600,118 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 743,892 | 1,321,860 | +577,968 | 0.85 | 1.17 | +0.33 | buy |
| Ensign Peak Advisors, Inc | 0 | 357,222 | +357,222 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 198,415 | +198,415 | 0.00 | 0.31 | +0.31 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 180,145 | +180,145 | 0.00 | 0.06 | +0.06 | buy |
| Regency Capital Management Inc.\DE | 526,978 | 704,974 | +177,996 | 4.02 | 4.20 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 526,438 | 676,128 | +149,690 | 0.00 | 0.00 | +0.00 | buy |
| Long Focus Capital Management, LLC | 195,175 | 340,422 | +145,247 | 0.25 | 0.39 | +0.14 | buy |
| Verition Fund Management LLC | 51,081 | 152,186 | +101,105 | 0.01 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,900 | +75,900 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 111,540 | 177,718 | +66,178 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 60,064 | +60,064 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 53,072 | +53,072 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 457,360 | 506,262 | +48,902 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 44,000 | 90,000 | +46,000 | 0.01 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 993,202 | 1,037,299 | +44,097 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 42,387 | +42,387 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 4,874 | 38,169 | +33,295 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 31,062 | +31,062 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 28,787 | +28,787 | 0.00 | 0.00 | +0.00 | buy |
| TBH Global Asset Management, LLC | 33,097 | 60,322 | +27,225 | 0.06 | 0.11 | +0.05 | buy |
| NORTHERN TRUST CORP | 221,589 | 248,431 | +26,842 | 0.00 | 0.00 | +0.00 | buy |
| LEVIN CAPITAL STRATEGIES, L.P. | 81,095 | 100,000 | +18,905 | 0.09 | 0.10 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 72,723 | 91,448 | +18,725 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 18,015 | +18,015 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,500 | 28,500 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 12,922 | +12,922 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 10,553 | 17,362 | +6,809 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,594 | 19,140 | +6,546 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 83,843 | 90,285 | +6,442 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 28,159 | 33,660 | +5,501 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,600 | 29,800 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 11,121 | 14,899 | +3,778 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 657,029 | 659,692 | +2,663 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,700 | 12,930 | +2,230 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,775 | 8,616 | +1,841 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 10,401 | 10,929 | +528 | 0.06 | 0.06 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,709 | 13,797 | +88 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 37 | +37 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,268 | 2,268 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 107,912 | 107,912 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 11,786 | 11,786 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 14,976 | 14,976 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 12,405 | 12,405 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 3,039,892 | 0 | 8.71 | 9.09 | +0.39 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,552 | 1,552 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,322 | 2,322 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,938 | 55,938 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,488 | 6,444 | -44 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 84 | 0 | -84 | 0.00 | 0.00 | -0.00 | sell |
| Coppell Advisory Solutions LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 40,066 | 39,883 | -183 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,295 | 2,106 | -189 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 18,641 | 18,360 | -281 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 11,462 | 11,025 | -437 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,010 | 10 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,061 | 4,569 | -1,492 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 358,561 | 357,035 | -1,526 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,604 | 4,297 | -2,307 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 41,023 | 35,460 | -5,563 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,663 | 0 | -10,663 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 17,998 | 0 | -17,998 | 0.01 | 0.00 | -0.01 | sell |
| WATER ISLAND CAPITAL LLC | 22,650 | 0 | -22,650 | 0.02 | 0.00 | -0.02 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 24,665 | 0 | -24,665 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 106,426 | 4,016 | -102,410 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 722,896 | 0 | -722,896 | 0.17 | 0.00 | -0.17 | sell |