| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Matrix Capital Management Company, LP | 6,922,870 | 6,922,870 | 0 | 40.08 | 65.48 | +25.40 | hold |
| Frazier Life Sciences Management, L.P. | 5,100,000 | 5,100,000 | 0 | 0.94 | 0.75 | -0.20 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,125 | 4,881,125 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Long Focus Capital Management, LLC | 4,619,582 | 4,619,582 | 0 | 1.63 | 1.25 | -0.38 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,372,884 | 4,372,884 | 0 | 0.82 | 0.59 | -0.23 | hold |
| BlackRock, Inc. | 3,405,477 | 3,560,424 | +154,947 | 0.00 | 0.00 | -0.00 | buy |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | 3,039,892 | 0 | 2.52 | 1.98 | -0.54 | hold |
| VANGUARD GROUP INC | 2,890,503 | 2,936,538 | +46,035 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 2,198,915 | 2,198,423 | -492 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 2,117,697 | 2,117,697 | 0 | 0.81 | 0.69 | -0.12 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,257,947 | 1,255,450 | -2,497 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 1,627,274 | 1,035,586 | -591,688 | 0.92 | 0.49 | -0.43 | sell |
| STATE STREET CORP | 878,871 | 926,534 | +47,663 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 185,221 | 617,338 | +432,117 | 0.00 | 0.00 | +0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 595,744 | 595,744 | 0 | 1.87 | 1.10 | -0.77 | hold |
| B Group, Inc. | 572,576 | 572,576 | 0 | 3.38 | 2.31 | -1.07 | hold |
| Regency Capital Management Inc.\DE | 612,689 | 538,584 | -74,105 | 1.80 | 1.22 | -0.58 | sell |
| DIMENSIONAL FUND ADVISORS LP | 497,275 | 517,916 | +20,641 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 481,231 | 442,789 | -38,442 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 433,641 | 412,809 | -20,832 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 515,555 | 360,483 | -155,072 | 0.56 | 0.26 | -0.29 | sell |
| UBS Group AG | 896,811 | 171,639 | -725,172 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 165,185 | +165,185 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 97,608 | 145,200 | +47,592 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,312 | 140,959 | +13,647 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 194,943 | 139,926 | -55,017 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,948 | 135,063 | +115 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 32,210 | 114,609 | +82,399 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 135,402 | 111,865 | -23,537 | 0.05 | 0.14 | +0.09 | sell |
| Bank of New York Mellon Corp | 95,736 | 107,923 | +12,187 | 0.00 | 0.00 | -0.00 | buy |
| Resolute Capital Asset Partners LLC | 91,006 | 91,006 | 0 | 0.29 | 0.24 | -0.05 | hold |
| Permanent Capital Management, LP | 147,769 | 75,864 | -71,905 | 0.17 | 0.08 | -0.09 | sell |
| Nuveen, LLC | 72,334 | 72,334 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 64,932 | 69,298 | +4,366 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 68,549 | +68,549 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 69,037 | 65,034 | -4,003 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 24,805 | 60,811 | +36,006 | 0.01 | 0.01 | +0.00 | buy |
| TBH Global Asset Management, LLC | 60,322 | 60,322 | 0 | 0.07 | 0.05 | -0.02 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,658 | 59,239 | -419 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 54,692 | +54,692 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 43,421 | 51,419 | +7,998 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,000 | 50,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 31,711 | 49,053 | +17,342 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 47,431 | +47,431 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 67,296 | 46,371 | -20,925 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 42,998 | +42,998 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 120,740 | 42,842 | -77,898 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 41,660 | 41,660 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 38,693 | 40,744 | +2,051 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 69,030 | 40,502 | -28,528 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 44,641 | 36,381 | -8,260 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 56,798 | 36,090 | -20,708 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,434 | 34,891 | +29,457 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 26,496 | 32,977 | +6,481 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 45,455 | 30,828 | -14,627 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,852 | 30,284 | -568 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 28,300 | 28,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 30,336 | 27,282 | -3,054 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 26,300 | +26,300 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 19,357 | 25,031 | +5,674 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,557 | 23,119 | -1,438 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 15,452 | 20,993 | +5,541 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,403 | 20,359 | -44 | 0.00 | 0.00 | -0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 10,609 | 18,984 | +8,375 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 18,700 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 14,941 | 17,539 | +2,598 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,276 | 16,276 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 14,109 | +14,109 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,157 | 13,862 | -3,295 | 0.00 | 0.00 | -0.00 | sell |
| BROWN ADVISORY INC | 0 | 13,400 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,104 | 13,104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,817 | 11,724 | -93 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 11,397 | 11,397 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 0 | 11,294 | +11,294 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,830 | +10,830 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,889 | 10,348 | -541 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 3,467 | 8,138 | +4,671 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,544 | 4,544 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,342 | 4,342 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 3,736 | 3,736 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,402 | 3,086 | +684 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,335 | 2,704 | +369 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,634 | +2,634 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 79 | 2,459 | +2,380 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,216 | 1,955 | -261 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 2,085 | 1,806 | -279 | 0.00 | 0.00 | -0.00 | sell |
| Smartleaf Asset Management LLC | 1,263 | 1,741 | +478 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 1,047 | 1,625 | +578 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 1,593 | +1,593 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,601 | 1,380 | -221 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,336 | 1,247 | -89 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 1,305 | 811 | -494 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 0 | 793 | +793 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 636 | 634 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 0 | 584 | +584 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 1 | 363 | +362 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 863 | 346 | -517 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 336 | 288 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 420 | 269 | -151 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 218 | 218 | 0 | 0.00 | 0.00 | -0.00 | hold |