| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 220,000 | 879,000 | +659,000 | 0.16 | 0.43 | +0.27 | buy |
| Eversept Partners, LP | 3,188,514 | 3,558,497 | +369,983 | 0.79 | 0.69 | -0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 10,098,824 | 10,439,185 | +340,361 | 0.93 | 0.59 | -0.34 | buy |
| DAFNA Capital Management LLC | 230,000 | 438,407 | +208,407 | 0.25 | 0.31 | +0.07 | buy |
| DRW Securities, LLC | 21,803 | 34,569 | +12,766 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 12,476 | 25,033 | +12,557 | 0.05 | 0.10 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 55,068 | 64,647 | +9,579 | 0.02 | 0.01 | -0.01 | buy |
| Stonepine Capital Management, LLC | 200,000 | 205,000 | +5,000 | 0.38 | 0.36 | -0.02 | buy |
| TEMA ETFS LLC | 227,505 | 228,987 | +1,482 | 0.07 | 0.03 | -0.04 | buy |
| J.Safra Asset Management Corp | 1,424 | 1,179 | -245 | 0.00 | 0.00 | -0.00 | sell |
| Formidable Asset Management, LLC | 18,263 | 17,710 | -553 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 288,057 | 169,831 | -118,226 | 0.37 | 0.15 | -0.23 | sell |
| 683 Capital Management, LLC | 425,000 | 20,000 | -405,000 | 0.10 | 0.00 | -0.10 | sell |
| VR Adviser, LLC | 9,982,124 | 4,982,124 | -5,000,000 | 1.75 | 0.57 | -1.18 | sell |