| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 3,544,578 | +3,544,578 | 0.00 | 0.14 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 1,598,590 | +1,598,590 | 0.00 | 1.21 | +1.21 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 1,274,507 | +1,274,507 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 936,778 | +936,778 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 855,984 | +855,984 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 679,403 | +679,403 | 0.00 | 0.98 | +0.98 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 293,894 | +293,894 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 250,910 | +250,910 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 14,141 | 253,773 | +239,632 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 191,060 | +191,060 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 183,748 | +183,748 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 155,000 | +155,000 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 259 | 133,199 | +132,940 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 123,653 | +123,653 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 196,520 | 304,334 | +107,814 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 41,200 | 146,800 | +105,600 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 87,226 | +87,226 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 0 | 85,638 | +85,638 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 150,533 | 210,151 | +59,618 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 56,745 | +56,745 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,595 | +55,595 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 702,654 | 753,398 | +50,744 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,646,190 | 2,690,830 | +44,640 | 0.02 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 104,162 | 148,567 | +44,405 | 0.01 | 0.03 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 41,745 | +41,745 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 38,578 | +38,578 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 71,300 | 107,700 | +36,400 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 35,400 | +35,400 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,921 | +31,921 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 26,114 | +26,114 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 18,900 | +18,900 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 18,246 | +18,246 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,056 | +18,056 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 16,831 | +16,831 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 16,300 | 31,900 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 11,049 | +11,049 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 434,524 | 443,224 | +8,700 | 0.01 | 0.02 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 6,064 | +6,064 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,134 | +1,134 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 41,725 | 42,798 | +1,073 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,485 | 4,388 | +903 | 0.00 | 0.00 | +0.00 | buy |
| OLD POINT TRUST & FINANCIAL SERVICES N A | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 6,595,801 | 6,595,801 | 0 | 0.26 | 0.40 | +0.14 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 81,352 | 81,352 | 0 | 0.02 | 0.03 | +0.01 | hold |
| RHUMBLINE ADVISERS | 1,291 | 1,291 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WHITTIER TRUST CO | 6,604 | 6,604 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 78 | 78 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Assenagon Asset Management S.A. | 404,674 | 404,674 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vontobel Holding Ltd. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearline Capital LP | 196,583 | 196,583 | 0 | 0.03 | 0.04 | +0.01 | hold |
| IPG Investment Advisors LLC | 12,500 | 12,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Raleigh Capital Management Inc. | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 53,243 | 53,243 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,817 | 24,817 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 637 | 637 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 267,476 | 267,476 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 1,251 | 1,218 | -33 | 0.00 | 0.00 | +0.00 | sell |
| Advisory Services Network, LLC | 274 | 0 | -274 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 11,577 | 10,811 | -766 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 44,730 | 43,865 | -865 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 135,302 | 134,118 | -1,184 | 0.00 | 0.00 | +0.00 | sell |
| MACKENZIE FINANCIAL CORP | 19,679 | 18,138 | -1,541 | 0.00 | 0.00 | +0.00 | sell |
| Private Advisor Group, LLC | 73,179 | 69,179 | -4,000 | 0.00 | 0.00 | +0.00 | sell |
| Congress Park Capital LLC | 239,300 | 233,800 | -5,500 | 0.18 | 0.23 | +0.04 | sell |
| Tower Research Capital LLC (TRC) | 7,184 | 0 | -7,184 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 20,273 | 12,553 | -7,720 | 0.01 | 0.00 | -0.00 | sell |
| Byrne Asset Management LLC | 8,000 | 0 | -8,000 | 0.01 | 0.00 | -0.01 | sell |
| Forefront Analytics, LLC | 30,846 | 20,889 | -9,957 | 0.02 | 0.02 | -0.00 | sell |
| Bronte Capital Management Pty Ltd. | 919,911 | 906,157 | -13,754 | 0.13 | 0.16 | +0.03 | sell |
| LPL Financial LLC | 110,265 | 92,315 | -17,950 | 0.00 | 0.00 | +0.00 | sell |
| Formidable Asset Management, LLC | 306,107 | 288,101 | -18,006 | 0.10 | 0.10 | +0.00 | sell |
| Tidal Investments LLC | 306,107 | 288,101 | -18,006 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 266,836 | 241,981 | -24,855 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 26,838 | 0 | -26,838 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 31,869 | 0 | -31,869 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 4,902,943 | 4,857,374 | -45,569 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,325,700 | 1,232,800 | -92,900 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 6,550,000 | 6,450,000 | -100,000 | 0.94 | 1.46 | +0.53 | sell |
| MILLENNIUM MANAGEMENT LLC | 794,047 | 671,628 | -122,419 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 253,283 | 0 | -253,283 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 791,421 | 529,935 | -261,486 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 363,276 | 52,289 | -310,987 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 1,093,921 | 764,187 | -329,734 | 0.06 | 0.05 | -0.01 | sell |
| FMR LLC | 565,324 | 183,077 | -382,247 | 0.00 | 0.00 | -0.00 | sell |