| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 0 | 1,657,306 | +1,657,306 | 0.00 | 0.01 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 38,885 | 762,930 | +724,045 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 508,556 | 746,788 | +238,232 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 599,850 | 711,454 | +111,604 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 97,123 | +97,123 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 3,137,046 | 3,234,035 | +96,989 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 85,539 | +85,539 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 61,719 | +61,719 | 0.00 | 0.00 | +0.00 | buy |
| Aspire Growth Partners LLC | 40,780 | 92,254 | +51,474 | 0.04 | 0.08 | +0.04 | buy |
| Laurion Capital Management LP | 1,248,364 | 1,293,686 | +45,322 | 0.08 | 0.06 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 815,643 | 857,958 | +42,315 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 35,000 | 75,000 | +40,000 | 0.03 | 0.05 | +0.02 | buy |
| Forefront Analytics, LLC | 64,259 | 100,070 | +35,811 | 0.03 | 0.07 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 507 | 33,853 | +33,346 | 0.00 | 0.00 | +0.00 | buy |
| Miller Financial Services LLC | 25,000 | 51,000 | +26,000 | 0.02 | 0.05 | +0.02 | buy |
| Prosight Management, LP | 3,905,000 | 3,930,008 | +25,008 | 1.13 | 0.82 | -0.31 | buy |
| PRUDENTIAL FINANCIAL INC | 64,300 | 81,500 | +17,200 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 34,054 | 44,576 | +10,522 | 0.00 | 0.00 | -0.00 | buy |
| Meridian Wealth Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,273 | 10,277 | +7,004 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 53,243 | 54,243 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,817 | 24,877 | +60 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,228,461 | 5,228,461 | 0 | 0.18 | 0.14 | -0.05 | hold |
| Nierenberg Investment Management Company, Inc. | 12,555 | 12,555 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 241,980 | 241,980 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Peregrine Asset Advisers, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Advisor Group, LLC | 44,002 | 44,002 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IPG Investment Advisors LLC | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 2,650,000 | 2,650,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 30,500 | 30,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 487,902 | 487,902 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 150,632 | 150,632 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE STREET CORP | 320,043 | 320,043 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 78 | 17 | -61 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 4,224 | 4,124 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Raleigh Capital Management Inc. | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 55,108 | 54,808 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Bell Investment Advisors, Inc | 388 | 0 | -388 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 1,107 | 108 | -999 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 5,505 | 816 | -4,689 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 8,924 | 0 | -8,924 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 36,992 | 17,708 | -19,284 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 30,792 | 7,392 | -23,400 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 331,624 | 306,624 | -25,000 | 0.01 | 0.00 | -0.00 | sell |
| Formidable Asset Management, LLC | 382,529 | 353,840 | -28,689 | 0.06 | 0.04 | -0.03 | sell |
| Tidal Investments LLC | 382,529 | 353,840 | -28,689 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 32,922 | 0 | -32,922 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 33,570 | 0 | -33,570 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 42,315 | 0 | -42,315 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 5,162,302 | 5,117,376 | -44,926 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 57,012 | 11,797 | -45,215 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 1,239,778 | 1,166,384 | -73,394 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 145,036 | 47,036 | -98,000 | 0.03 | 0.01 | -0.03 | sell |
| Cubist Systematic Strategies, LLC | 98,383 | 0 | -98,383 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 110,242 | 0 | -110,242 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,346,800 | 1,156,000 | -190,800 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 306,783 | 108,311 | -198,472 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 320,767 | 116,475 | -204,292 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 286,480 | 0 | -286,480 | 0.00 | 0.00 | -0.00 | sell |
| Congress Park Capital LLC | 964,590 | 673,686 | -290,904 | 0.36 | 0.16 | -0.20 | sell |
| CITADEL ADVISORS LLC | 322,311 | 0 | -322,311 | 0.00 | 0.00 | -0.00 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 364,306 | 0 | -364,306 | 0.35 | 0.00 | -0.35 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,221,012 | 2,826,276 | -394,736 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 467,491 | 0 | -467,491 | 0.15 | 0.00 | -0.15 | sell |
| TANG CAPITAL MANAGEMENT LLC | 7,311,760 | 6,717,825 | -593,935 | 0.50 | 0.24 | -0.26 | sell |
| JPMORGAN CHASE & CO | 811,630 | 105,294 | -706,336 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 1,380,800 | 589,332 | -791,468 | 0.01 | 0.00 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,547,215 | 686,208 | -861,007 | 0.01 | 0.00 | -0.00 | sell |