| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 24,688,109 | 31,955,637 | +7,267,528 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 8,966,077 | 15,013,093 | +6,047,016 | 2.49 | 4.48 | +1.99 | buy |
| BANK OF AMERICA CORP /DE/ | 876,305 | 10,202,785 | +9,326,480 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 9,680,185 | 10,098,824 | +418,639 | 0.76 | 0.94 | +0.18 | buy |
| VR Adviser, LLC | 15,561,500 | 9,982,124 | -5,579,376 | 3.27 | 1.75 | -1.52 | sell |
| Point72 Asset Management, L.P. | 5,189,538 | 7,875,390 | +2,685,852 | 0.03 | 0.06 | +0.03 | buy |
| STATE STREET CORP | 5,140,931 | 5,663,408 | +522,477 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 342,304 | 5,406,193 | +5,063,889 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 3,669,393 | 5,228,280 | +1,558,887 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,250,826 | 4,975,826 | +725,000 | 0.11 | 0.13 | +0.03 | buy |
| Nextech Invest, Ltd. | 0 | 4,449,932 | +4,449,932 | 0.00 | 1.47 | +1.47 | buy |
| MARSHALL WACE, LLP | 1,156,936 | 4,138,176 | +2,981,240 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 289,653 | 3,660,190 | +3,370,537 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 3,582,985 | +3,582,985 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 3,457,711 | +3,457,711 | 0.00 | 0.45 | +0.45 | buy |
| ADAR1 Capital Management, LLC | 4,182,769 | 3,410,190 | -772,579 | 1.33 | 0.96 | -0.37 | sell |
| Eversept Partners, LP | 2,507,090 | 3,188,514 | +681,424 | 0.60 | 0.99 | +0.39 | buy |
| UBS Group AG | 370,739 | 3,120,155 | +2,749,416 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 23,764 | 3,067,864 | +3,044,100 | 0.00 | 0.18 | +0.18 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,560,755 | 2,710,156 | +1,149,401 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,061,128 | 2,249,583 | +1,188,455 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,525,666 | 2,066,612 | +540,946 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,337,005 | 2,000,825 | -336,180 | 0.04 | 0.04 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,289,656 | 1,930,920 | +641,264 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 981,598 | 1,869,615 | +888,017 | 0.01 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 2,460,944 | 1,459,839 | -1,001,105 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 0 | 1,120,309 | +1,120,309 | 0.00 | 0.06 | +0.06 | buy |
| Patient Square Capital LP | 0 | 1,085,790 | +1,085,790 | 0.00 | 0.91 | +0.91 | buy |
| JANE STREET GROUP, LLC | 607,218 | 997,510 | +390,292 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 900,000 | +900,000 | 0.00 | 0.07 | +0.07 | buy |
| Ally Bridge Group (NY) LLC | 0 | 900,000 | +900,000 | 0.00 | 4.20 | +4.20 | buy |
| Trexquant Investment LP | 0 | 898,767 | +898,767 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,872,202 | 730,844 | -3,141,358 | 0.03 | 0.01 | -0.02 | sell |
| NORTHERN TRUST CORP | 415,178 | 612,141 | +196,963 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,825 | 606,275 | +603,450 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 592,473 | +592,473 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 573,224 | +573,224 | 0.00 | 0.13 | +0.13 | buy |
| FIRST TRUST ADVISORS LP | 423,168 | 568,562 | +145,394 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 203,823 | 565,113 | +361,290 | 0.10 | 0.31 | +0.21 | buy |
| Longaeva Partners L.P. | 0 | 550,000 | +550,000 | 0.00 | 0.12 | +0.12 | buy |
| Velan Capital Investment Management LP | 80,000 | 540,000 | +460,000 | 0.20 | 1.59 | +1.39 | buy |
| Exome Asset Management LLC | 745,305 | 521,468 | -223,837 | 1.57 | 1.44 | -0.13 | sell |
| MORGAN STANLEY | 401,191 | 520,495 | +119,304 | 0.00 | 0.00 | +0.00 | buy |
| SCHULHOFF & CO INC | 374,850 | 477,550 | +102,700 | 0.67 | 0.92 | +0.25 | buy |
| DEUTSCHE BANK AG\ | 0 | 463,421 | +463,421 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 425,000 | +425,000 | 0.00 | 0.19 | +0.19 | buy |
| RAYMOND JAMES FINANCIAL INC | 316,971 | 380,160 | +63,189 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 592,696 | 364,173 | -228,523 | 0.00 | 0.00 | -0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 0 | 325,000 | +325,000 | 0.00 | 0.10 | +0.10 | buy |
| Swiss National Bank | 0 | 319,600 | +319,600 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 300,000 | +300,000 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 328,248 | 289,868 | -38,380 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 193,941 | 288,057 | +94,116 | 0.21 | 0.37 | +0.16 | buy |
| Brevan Howard Capital Management LP | 11,404 | 269,202 | +257,798 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 24,051 | 248,438 | +224,387 | 0.00 | 0.04 | +0.03 | buy |
| SEI INVESTMENTS CO | 124,124 | 248,248 | +124,124 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 45,763 | 245,768 | +200,005 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 49,897 | 241,215 | +191,318 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 273,584 | 239,824 | -33,760 | 0.00 | 0.00 | +0.00 | sell |
| LMR Partners LLP | 0 | 234,931 | +234,931 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 0 | 230,598 | +230,598 | 0.00 | 0.90 | +0.90 | buy |
| DAFNA Capital Management LLC | 0 | 230,000 | +230,000 | 0.00 | 0.25 | +0.25 | buy |
| TEMA ETFS LLC | 0 | 227,505 | +227,505 | 0.00 | 0.07 | +0.07 | buy |
| Burkehill Global Management, LP | 0 | 225,000 | +225,000 | 0.00 | 0.05 | +0.05 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 220,000 | +220,000 | 0.00 | 0.18 | +0.18 | buy |
| Stonepine Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.83 | +0.83 | buy |
| Centiva Capital, LP | 0 | 200,000 | +200,000 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 189,400 | +189,400 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 167,514 | +167,514 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 154,134 | +154,134 | 0.00 | 0.02 | +0.02 | buy |
| AWM Investment Company, Inc. | 0 | 150,000 | +150,000 | 0.00 | 0.08 | +0.08 | buy |
| BARCLAYS PLC | 336,525 | 142,412 | -194,113 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 0 | 141,893 | +141,893 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,687 | 128,796 | +60,109 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 113,440 | 122,634 | +9,194 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 206,526 | 121,912 | -84,614 | 0.06 | 0.04 | -0.02 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 104,200 | 108,800 | +4,600 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 105,820 | +105,820 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 21,212 | 104,750 | +83,538 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 98,633 | 104,535 | +5,902 | 0.01 | 0.02 | +0.01 | buy |
| Aspire Growth Partners LLC | 102,254 | 102,254 | 0 | 0.30 | 0.33 | +0.03 | hold |
| Virtu Financial LLC | 0 | 101,895 | +101,895 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 96,326 | 101,801 | +5,475 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 96,100 | +96,100 | 0.00 | 1.09 | +1.09 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 94,240 | +94,240 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 88,379 | +88,379 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 50,990 | 80,663 | +29,673 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 47,991 | 77,861 | +29,870 | 0.01 | 0.01 | +0.00 | buy |
| Miller Financial Services LLC | 68,000 | 72,000 | +4,000 | 0.34 | 0.38 | +0.04 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 68,378 | +68,378 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 67,732 | +67,732 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 63,491 | 65,080 | +1,589 | 0.07 | 0.08 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 229,599 | 65,015 | -164,584 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 856,056 | 63,694 | -792,362 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 87,800 | 62,400 | -25,400 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 21,976 | 61,555 | +39,579 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 57,475 | +57,475 | 0.00 | 0.07 | +0.07 | buy |
| Brooklyn Investment Group | 61,474 | 55,478 | -5,996 | 0.01 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 27,609 | 55,068 | +27,459 | 0.01 | 0.02 | +0.01 | buy |
| Merit Financial Group, LLC | 53,243 | 53,243 | 0 | 0.00 | 0.00 | +0.00 | hold |