| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 0 | 13,969,882 | +13,969,882 | 0.00 | 2.38 | +2.38 | buy |
| FMR LLC | 108,311 | 9,238,868 | +9,130,557 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 8,461,500 | +8,461,500 | 0.00 | 0.48 | +0.48 | buy |
| Commodore Capital LP | 0 | 7,692,300 | +7,692,300 | 0.00 | 1.23 | +1.23 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 6,993,646 | +6,993,646 | 0.00 | 0.60 | +0.60 | buy |
| Vivo Capital, LLC | 0 | 5,769,230 | +5,769,230 | 0.00 | 1.34 | +1.34 | buy |
| FRANKLIN RESOURCES INC | 0 | 5,769,230 | +5,769,230 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,650,000 | 8,084,623 | +5,434,623 | 0.00 | 0.04 | +0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 6,717,825 | 11,065,662 | +4,347,837 | 0.24 | 1.27 | +1.03 | buy |
| VANGUARD GROUP INC | 5,117,376 | 9,379,794 | +4,262,418 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 0 | 3,896,582 | +3,896,582 | 0.00 | 1.15 | +1.15 | buy |
| BAKER BROS. ADVISORS LP | 0 | 3,484,226 | +3,484,226 | 0.00 | 0.08 | +0.08 | buy |
| RTW INVESTMENTS, LP | 0 | 3,461,500 | +3,461,500 | 0.00 | 0.11 | +0.11 | buy |
| ADAR1 Capital Management, LLC | 47,036 | 3,081,414 | +3,034,378 | 0.01 | 1.14 | +1.13 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,865,625 | +2,865,625 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 85,539 | 2,353,122 | +2,267,583 | 0.00 | 0.01 | +0.01 | buy |
| Kynam Capital Management, LP | 0 | 2,154,413 | +2,154,413 | 0.00 | 0.53 | +0.53 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,000,000 | 2,661,331 | +1,661,331 | 0.01 | 0.10 | +0.09 | buy |
| Soleus Capital Management, L.P. | 0 | 1,304,300 | +1,304,300 | 0.00 | 0.20 | +0.20 | buy |
| BlackRock, Inc. | 1,166,384 | 2,388,453 | +1,222,069 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 857,958 | 1,745,176 | +887,218 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 844,643 | +844,643 | 0.00 | 0.08 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,156,000 | 1,862,200 | +706,200 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,657,306 | 2,336,899 | +679,593 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 320,043 | 639,040 | +318,997 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 150,632 | 450,107 | +299,475 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 291,896 | +291,896 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 283,560 | +283,560 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 254,580 | +254,580 | 0.00 | 0.09 | +0.09 | buy |
| ROYAL BANK OF CANADA | 0 | 243,547 | +243,547 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 201,224 | +201,224 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 183,166 | +183,166 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 121,899 | +121,899 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 99,410 | +99,410 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,877 | 88,570 | +63,693 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 50,117 | +50,117 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 49,392 | +49,392 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 47,311 | +47,311 | 0.00 | 0.01 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 816 | 43,316 | +42,500 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 116,475 | 157,681 | +41,206 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 11,797 | 35,136 | +23,339 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,277 | 29,661 | +19,384 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 14,868 | +14,868 | 0.00 | 0.01 | +0.01 | buy |
| PURSUE WEALTH PARTNERS LLC | 0 | 14,492 | +14,492 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 0 | 14,171 | +14,171 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 12,435 | +12,435 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 17,708 | 28,966 | +11,258 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 241,980 | 252,659 | +10,679 | 0.00 | 0.00 | +0.00 | buy |
| Aspire Growth Partners LLC | 92,254 | 102,254 | +10,000 | 0.08 | 0.19 | +0.11 | buy |
| Assenagon Asset Management S.A. | 711,454 | 720,020 | +8,566 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Asset Management, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,656 | +1,656 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 398 | +398 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nierenberg Investment Management Company, Inc. | 12,555 | 12,555 | 0 | 0.00 | 0.02 | +0.01 | hold |
| Peregrine Asset Advisers, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Private Advisor Group, LLC | 44,002 | 44,002 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IPG Investment Advisors LLC | 12,500 | 12,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Meridian Wealth Management, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Velan Capital Investment Management LP | 75,000 | 75,000 | 0 | 0.05 | 0.17 | +0.12 | hold |
| Miller Financial Services LLC | 51,000 | 51,000 | 0 | 0.05 | 0.15 | +0.10 | hold |
| BARCLAYS PLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SBI Securities Co., Ltd. | 108 | 84 | -24 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 54,243 | 53,243 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 4,124 | 0 | -4,124 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 7,392 | 0 | -7,392 | 0.00 | 0.00 | -0.00 | sell |
| TRAPHAGEN INVESTMENT ADVISORS LLC | 30,500 | 0 | -30,500 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 33,853 | 0 | -33,853 | 0.00 | 0.00 | -0.00 | sell |
| Formidable Asset Management, LLC | 353,840 | 312,850 | -40,990 | 0.04 | 0.12 | +0.08 | sell |
| Tidal Investments LLC | 353,840 | 312,850 | -40,990 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 44,576 | 0 | -44,576 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 61,719 | 14,678 | -47,041 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 54,808 | 0 | -54,808 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 81,500 | 25,700 | -55,800 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 100,070 | 27,698 | -72,372 | 0.07 | 0.03 | -0.04 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 97,123 | 0 | -97,123 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 105,294 | 0 | -105,294 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 762,930 | 630,809 | -132,121 | 0.04 | 0.10 | +0.06 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 306,624 | 126,000 | -180,624 | 0.00 | 0.01 | +0.00 | sell |
| UBS Group AG | 746,788 | 408,035 | -338,753 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 3,930,008 | 3,517,113 | -412,895 | 0.82 | 1.95 | +1.13 | sell |
| SEI INVESTMENTS CO | 487,902 | 0 | -487,902 | 0.00 | 0.00 | -0.00 | sell |
| Congress Park Capital LLC | 673,686 | 95,422 | -578,264 | 0.16 | 0.07 | -0.09 | sell |
| Schonfeld Strategic Advisors LLC | 589,332 | 0 | -589,332 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 686,208 | 0 | -686,208 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 1,293,686 | 0 | -1,293,686 | 0.06 | 0.00 | -0.06 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 3,234,035 | 1,557,036 | -1,676,999 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,826,276 | 233,339 | -2,592,937 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 5,228,461 | 0 | -5,228,461 | 0.14 | 0.00 | -0.14 | sell |