| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GEODE CAPITAL MANAGEMENT, LLC | 2,066,612 | 4,678,716 | +2,612,104 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,710,156 | 4,132,643 | +1,422,487 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 289,868 | 684,539 | +394,671 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 10,098,824 | 10,439,185 | +340,361 | 0.94 | 0.61 | -0.33 | buy |
| RHUMBLINE ADVISERS | 0 | 222,514 | +222,514 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 230,000 | 438,407 | +208,407 | 0.25 | 0.31 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,379 | 208,477 | +120,098 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 104,310 | +104,310 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 90,900 | +90,900 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 122,634 | 171,733 | +49,099 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 42,014 | +42,014 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 36,863 | +36,863 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 33,686 | +33,686 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 108,800 | 141,500 | +32,700 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,988 | 79,816 | +31,828 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 568,562 | 599,696 | +31,134 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 30,448 | +30,448 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 30,434 | +30,434 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 27,950 | +27,950 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 16,154 | +16,154 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 15,482 | +15,482 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO | 0 | 11,458 | +11,458 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 104,535 | 111,378 | +6,843 | 0.02 | 0.01 | -0.01 | buy |
| Stonepine Capital Management, LLC | 200,000 | 205,000 | +5,000 | 0.83 | 0.59 | -0.24 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,161 | 19,306 | +4,145 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 0 | 1,969 | +1,969 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 105,820 | 107,100 | +1,280 | 0.00 | 0.00 | -0.00 | buy |
| SCHULHOFF & CO INC | 477,550 | 477,550 | 0 | 0.92 | 0.72 | -0.20 | hold |
| BAKER BROS. ADVISORS LP | 4,975,826 | 4,975,826 | 0 | 0.13 | 0.09 | -0.04 | hold |
| Nierenberg Investment Management Company, Inc. | 12,555 | 12,555 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Rafferty Asset Management, LLC | 239,824 | 221,377 | -18,447 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 19,140 | 0 | -19,140 | 0.01 | 0.00 | -0.01 | sell |
| Mariner, LLC | 19,750 | 0 | -19,750 | 0.00 | 0.00 | -0.00 | sell |
| GABELLI FUNDS LLC | 33,000 | 0 | -33,000 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 62,400 | 0 | -62,400 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 80,663 | 0 | -80,663 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 288,057 | 169,831 | -118,226 | 0.37 | 0.15 | -0.23 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 121,912 | 0 | -121,912 | 0.04 | 0.00 | -0.04 | sell |
| 683 Capital Management, LLC | 425,000 | 20,000 | -405,000 | 0.19 | 0.01 | -0.18 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 606,275 | 31,712 | -574,563 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 730,844 | 0 | -730,844 | 0.01 | 0.00 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 900,000 | 0 | -900,000 | 0.07 | 0.00 | -0.07 | sell |
| MARSHALL WACE, LLP | 4,138,176 | 3,024,351 | -1,113,825 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,660,190 | 1,685,830 | -1,974,360 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 5,406,193 | 3,110,509 | -2,295,684 | 0.02 | 0.01 | -0.01 | sell |