| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 31,955,637 | 32,714,937 | +759,300 | 0.01 | 0.01 | -0.00 | buy |
| Kynam Capital Management, LP | 15,013,093 | 21,703,093 | +6,690,000 | 4.48 | 4.50 | +0.02 | buy |
| BlackRock, Inc. | 5,228,280 | 17,559,822 | +12,331,542 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 10,202,785 | 15,082,617 | +4,879,832 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 5,663,408 | 11,747,236 | +6,083,828 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 10,098,824 | 10,439,185 | +340,361 | 0.94 | 0.61 | -0.33 | buy |
| Point72 Asset Management, L.P. | 7,875,390 | 7,811,033 | -64,357 | 0.06 | 0.04 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,582,985 | 5,168,961 | +1,585,976 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 9,982,124 | 4,982,124 | -5,000,000 | 1.75 | 0.57 | -1.18 | sell |
| BAKER BROS. ADVISORS LP | 4,975,826 | 4,975,826 | 0 | 0.13 | 0.09 | -0.04 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,066,612 | 4,678,716 | +2,612,104 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 4,449,932 | 4,449,932 | 0 | 1.47 | 0.79 | -0.68 | hold |
| TWO SIGMA INVESTMENTS, LP | 2,710,156 | 4,132,643 | +1,422,487 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 3,188,514 | 3,558,497 | +369,983 | 0.99 | 0.73 | -0.26 | buy |
| UBS Group AG | 3,120,155 | 3,468,359 | +348,204 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 3,457,711 | 3,457,711 | 0 | 0.45 | 0.26 | -0.19 | hold |
| ADAR1 Capital Management, LLC | 3,410,190 | 3,365,118 | -45,072 | 0.96 | 0.59 | -0.37 | sell |
| CITADEL ADVISORS LLC | 5,406,193 | 3,110,509 | -2,295,684 | 0.02 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 4,138,176 | 3,024,351 | -1,113,825 | 0.02 | 0.01 | -0.01 | sell |
| Woodline Partners LP | 2,000,825 | 2,040,210 | +39,385 | 0.04 | 0.02 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,459,839 | 2,003,652 | +543,813 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,930,920 | 1,860,290 | -70,630 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 2,249,583 | 1,824,564 | -425,019 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,660,190 | 1,685,830 | -1,974,360 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 612,141 | 1,675,183 | +1,063,042 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 1,380,687 | +1,380,687 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 220,000 | 879,000 | +659,000 | 0.18 | 0.47 | +0.29 | buy |
| Ally Bridge Group (NY) LLC | 900,000 | 775,000 | -125,000 | 4.20 | 3.75 | -0.46 | sell |
| GILDER GAGNON HOWE & CO LLC | 1,120,309 | 704,423 | -415,886 | 0.06 | 0.03 | -0.04 | sell |
| Bank of New York Mellon Corp | 289,868 | 684,539 | +394,671 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 463,421 | 663,038 | +199,617 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 568,562 | 599,696 | +31,134 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 549,875 | +549,875 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 128,796 | 549,875 | +421,079 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 592,473 | 505,055 | -87,418 | 0.01 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 380,160 | 484,222 | +104,062 | 0.00 | 0.00 | -0.00 | buy |
| SCHULHOFF & CO INC | 477,550 | 477,550 | 0 | 0.92 | 0.72 | -0.20 | hold |
| Exome Asset Management LLC | 521,468 | 460,067 | -61,401 | 1.44 | 1.06 | -0.38 | sell |
| Nuveen, LLC | 0 | 448,041 | +448,041 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 230,000 | 438,407 | +208,407 | 0.25 | 0.31 | +0.07 | buy |
| Assenagon Asset Management S.A. | 364,173 | 364,173 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 10,724 | 347,400 | +336,676 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 319,600 | 325,400 | +5,800 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 573,224 | 300,000 | -273,224 | 0.13 | 0.04 | -0.09 | sell |
| CITIGROUP INC | 101,801 | 287,866 | +186,065 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 234,931 | 273,213 | +38,282 | 0.01 | 0.01 | -0.00 | buy |
| Tidal Investments LLC | 245,768 | 246,697 | +929 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 227,505 | 228,987 | +1,482 | 0.07 | 0.03 | -0.04 | buy |
| RHUMBLINE ADVISERS | 0 | 222,514 | +222,514 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 239,824 | 221,377 | -18,447 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 61,555 | 220,205 | +158,650 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 189,400 | 219,779 | +30,379 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,379 | 208,477 | +120,098 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 200,000 | 205,000 | +5,000 | 0.83 | 0.59 | -0.24 | buy |
| Focus Partners Wealth | 0 | 197,878 | +197,878 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 122,634 | 171,733 | +49,099 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 288,057 | 169,831 | -118,226 | 0.37 | 0.15 | -0.23 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 163,183 | +163,183 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 150,000 | 150,000 | 0 | 0.08 | 0.05 | -0.03 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 148,107 | +148,107 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 108,800 | 141,500 | +32,700 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 126,526 | +126,526 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 142,412 | 126,415 | -15,997 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 141,893 | 123,313 | -18,580 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 540,000 | 120,000 | -420,000 | 1.59 | 0.28 | -1.31 | sell |
| Squarepoint Ops LLC | 241,215 | 112,152 | -129,063 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 104,535 | 111,378 | +6,843 | 0.02 | 0.01 | -0.01 | buy |
| JPMORGAN CHASE & CO | 30,741 | 109,413 | +78,672 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 65,080 | 108,703 | +43,623 | 0.08 | 0.09 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,683 | 107,334 | +90,651 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 105,820 | 107,100 | +1,280 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 104,635 | +104,635 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 104,310 | +104,310 | 0.00 | 0.00 | +0.00 | buy |
| Aspire Growth Partners LLC | 102,254 | 102,254 | 0 | 0.33 | 0.22 | -0.11 | hold |
| Robertson Stephens Wealth Management, LLC | 0 | 96,000 | +96,000 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 94,240 | 94,240 | 0 | 0.03 | 0.02 | -0.01 | hold |
| ALGERT GLOBAL LLC | 0 | 90,900 | +90,900 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,869,615 | 90,673 | -1,778,942 | 0.01 | 0.00 | -0.01 | sell |
| Miller Financial Services LLC | 72,000 | 85,000 | +13,000 | 0.38 | 0.26 | -0.12 | buy |
| Engineers Gate Manager LP | 29,477 | 83,130 | +53,653 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,988 | 79,816 | +31,828 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 55,068 | 64,647 | +9,579 | 0.02 | 0.01 | -0.01 | buy |
| State of Wyoming | 52,692 | 54,987 | +2,295 | 0.03 | 0.02 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 54,899 | +54,899 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 44,002 | 54,502 | +10,500 | 0.00 | 0.00 | -0.00 | buy |
| Merit Financial Group, LLC | 53,243 | 53,503 | +260 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 52,499 | +52,499 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 31,848 | 52,424 | +20,576 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 26,660 | 50,529 | +23,869 | 0.00 | 0.00 | +0.00 | buy |
| Congress Park Capital LLC | 49,171 | 49,171 | 0 | 0.07 | 0.05 | -0.02 | hold |
| TWINBEECH CAPITAL LP | 0 | 48,404 | +48,404 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 48,012 | 48,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 47,795 | +47,795 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 77,861 | 46,981 | -30,880 | 0.01 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 45,000 | 45,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Arizona State Retirement System | 44,377 | 44,737 | +360 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 42,014 | +42,014 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 248,248 | 40,499 | -207,749 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 36,863 | +36,863 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 37,806 | 36,673 | -1,133 | 0.00 | 0.00 | -0.00 | sell |