| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 0 | 3,022,109 | +3,022,109 | 0.00 | 0.90 | +0.90 | buy |
| Altium Capital Management LLC | 0 | 915,000 | +915,000 | 0.00 | 0.32 | +0.32 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,845,403 | 2,560,256 | +714,853 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 1,238,499 | 1,644,168 | +405,669 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 393,832 | +393,832 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,728,569 | 3,100,994 | +372,425 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 572,170 | 903,959 | +331,789 | 0.14 | 0.18 | +0.04 | buy |
| VANGUARD GROUP INC | 4,892,302 | 5,162,302 | +270,000 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 382,723 | 487,902 | +105,179 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 88,518 | +88,518 | 0.00 | 0.01 | +0.01 | buy |
| Congress Park Capital LLC | 1,153,220 | 1,216,008 | +62,788 | 0.57 | 0.53 | -0.03 | buy |
| FMR LLC | 242,358 | 284,307 | +41,949 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 769,499 | 803,531 | +34,032 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 33,792 | +33,792 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,840 | +26,840 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 254,220 | 280,593 | +26,373 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 7,791,936 | 7,811,760 | +19,824 | 0.97 | 0.66 | -0.31 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,507,717 | 1,524,076 | +16,359 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 23,094 | 37,464 | +14,370 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 10,432 | +10,432 | 0.00 | 0.00 | +0.00 | buy |
| Peregrine Asset Advisers, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 42,814 | 47,649 | +4,835 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 36,315 | 38,315 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 54,608 | 55,108 | +500 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 78 | 194 | +116 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 117 | 117 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,228,461 | 5,228,461 | 0 | 0.18 | 0.18 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 36,500 | 36,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Nierenberg Investment Management Company, Inc. | 12,555 | 12,555 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 241,982 | 241,982 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 107,000 | 107,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Advisor Group, LLC | 52,179 | 52,179 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IPG Investment Advisors LLC | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 8,924 | 8,924 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Raleigh Capital Management Inc. | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 54,243 | 54,243 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,817 | 24,817 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 263,643 | 263,643 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INNEALTA CAPITAL, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 47,100 | 46,100 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 131,027 | 129,886 | -1,141 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 1,291 | 0 | -1,291 | 0.00 | 0.00 | -0.00 | sell |
| WHITTIER TRUST CO | 2,200 | 0 | -2,200 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,891 | 0 | -3,891 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 64,065 | 59,760 | -4,305 | 0.04 | 0.03 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 18,481 | 8,828 | -9,653 | 0.00 | 0.00 | -0.00 | sell |
| Formidable Asset Management, LLC | 258,001 | 246,001 | -12,000 | 0.05 | 0.05 | -0.00 | sell |
| Tidal Investments LLC | 258,001 | 246,001 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 16,964 | 4,911 | -12,053 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 369,124 | 356,624 | -12,500 | 0.01 | 0.01 | -0.00 | sell |
| LMR Partners LLP | 15,046 | 0 | -15,046 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 60,586 | 43,664 | -16,922 | 0.01 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 17,039 | 0 | -17,039 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 80,591 | 41,458 | -39,133 | 0.02 | 0.01 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 82,054 | 24,460 | -57,594 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 109,302 | 12,000 | -97,302 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 158,400 | 0 | -158,400 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 1,375,290 | 1,211,800 | -163,490 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,183,022 | 1,015,000 | -168,022 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 494,643 | 317,119 | -177,524 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 661,947 | 471,468 | -190,479 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 198,840 | 0 | -198,840 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 210,027 | 0 | -210,027 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 229,093 | 0 | -229,093 | 0.02 | 0.00 | -0.02 | sell |
| Laurion Capital Management LP | 1,526,387 | 1,248,364 | -278,023 | 0.06 | 0.09 | +0.03 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,151,518 | 0 | -1,151,518 | 1.77 | 0.00 | -1.77 | sell |
| RTW INVESTMENTS, LP | 1,200,002 | 0 | -1,200,002 | 0.02 | 0.00 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 6,301,983 | 4,809,518 | -1,492,465 | 0.00 | 0.00 | -0.00 | sell |