| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 13,969,882 | 15,561,500 | +1,591,618 | 2.38 | 2.79 | +0.42 | buy |
| FMR LLC | 9,238,868 | 15,396,200 | +6,157,332 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 11,065,662 | 11,065,662 | 0 | 1.27 | 1.36 | +0.09 | hold |
| PERCEPTIVE ADVISORS LLC | 6,993,646 | 9,680,185 | +2,686,539 | 0.60 | 0.89 | +0.30 | buy |
| VANGUARD GROUP INC | 9,379,794 | 8,947,807 | -431,987 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 8,461,500 | 8,461,500 | 0 | 0.48 | 0.65 | +0.16 | hold |
| Commodore Capital LP | 7,692,300 | 7,692,300 | 0 | 1.23 | 1.20 | -0.03 | hold |
| BAKER BROS. ADVISORS LP | 3,484,226 | 4,250,826 | +766,600 | 0.08 | 0.10 | +0.02 | buy |
| Point72 Asset Management, L.P. | 8,084,623 | 4,068,575 | -4,016,048 | 0.04 | 0.03 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 3,081,414 | 4,045,414 | +964,000 | 1.14 | 1.28 | +0.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,865,625 | 3,913,081 | +1,047,456 | 0.01 | 0.03 | +0.01 | buy |
| Kynam Capital Management, LP | 2,154,413 | 3,646,503 | +1,492,090 | 0.53 | 0.87 | +0.34 | buy |
| RTW INVESTMENTS, LP | 3,461,500 | 3,461,500 | 0 | 0.11 | 0.14 | +0.02 | hold |
| Ikarian Capital, LLC | 0 | 3,372,616 | +3,372,616 | 0.00 | 2.18 | +2.18 | buy |
| Vivo Capital, LLC | 5,769,230 | 2,884,615 | -2,884,615 | 1.34 | 0.74 | -0.60 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,661,331 | 2,661,331 | 0 | 0.10 | 0.10 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,862,200 | 2,545,260 | +683,060 | 0.01 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 2,388,453 | 2,381,912 | -6,541 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 2,336,899 | 2,337,005 | +106 | 0.03 | 0.04 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 1,800,435 | +1,800,435 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,745,176 | 1,569,298 | -175,878 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 233,339 | 1,386,863 | +1,153,524 | 0.00 | 0.00 | +0.00 | buy |
| Financial Engines Advisors L.L.C. | 0 | 1,381,357 | +1,381,357 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 1,237,057 | +1,237,057 | 0.00 | 0.10 | +0.10 | buy |
| MARSHALL WACE, LLP | 2,353,122 | 1,104,993 | -1,248,129 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 1,005,228 | +1,005,228 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 745,305 | +745,305 | 0.00 | 1.57 | +1.57 | buy |
| Assenagon Asset Management S.A. | 720,020 | 729,967 | +9,947 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 157,681 | 729,698 | +572,017 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,557,036 | 653,725 | -903,311 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 639,040 | 644,982 | +5,942 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 3,517,113 | 564,800 | -2,952,313 | 1.95 | 0.43 | -1.51 | sell |
| GSA CAPITAL PARTNERS LLP | 630,809 | 535,974 | -94,835 | 0.10 | 0.14 | +0.04 | sell |
| Inspire Investing, LLC | 0 | 522,482 | +522,482 | 0.00 | 0.16 | +0.16 | buy |
| DIMENSIONAL FUND ADVISORS LP | 183,166 | 451,128 | +267,962 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 14,678 | 447,753 | +433,075 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 401,891 | +401,891 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 401,367 | +401,367 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 450,107 | 389,685 | -60,422 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 283,560 | 293,560 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 291,896 | 267,485 | -24,411 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 0 | 257,148 | +257,148 | 0.00 | 0.20 | +0.20 | buy |
| Bank of New York Mellon Corp | 252,659 | 252,659 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Precision Wealth Strategies, LLC | 0 | 237,081 | +237,081 | 0.00 | 0.25 | +0.25 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 206,526 | +206,526 | 0.00 | 0.05 | +0.05 | buy |
| DIADEMA PARTNERS LP | 0 | 185,286 | +185,286 | 0.00 | 0.41 | +0.41 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 158,329 | +158,329 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 243,547 | 152,304 | -91,243 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 125,035 | +125,035 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.32 | +0.32 | buy |
| Qube Research & Technologies Ltd | 0 | 122,500 | +122,500 | 0.00 | 0.00 | +0.00 | buy |
| Formidable Asset Management, LLC | 312,850 | 118,337 | -194,513 | 0.12 | 0.06 | -0.06 | sell |
| Tidal Investments LLC | 312,850 | 118,337 | -194,513 | 0.00 | 0.00 | -0.00 | sell |
| Congress Park Capital LLC | 95,422 | 103,922 | +8,500 | 0.07 | 0.10 | +0.03 | buy |
| Aspire Growth Partners LLC | 102,254 | 102,254 | 0 | 0.19 | 0.24 | +0.05 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,570 | 88,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brooklyn Investment Group | 0 | 87,160 | +87,160 | 0.00 | 0.03 | +0.03 | buy |
| LPL Financial LLC | 201,224 | 86,653 | -114,571 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 75,000 | 80,000 | +5,000 | 0.17 | 0.24 | +0.07 | buy |
| Miller Financial Services LLC | 51,000 | 67,000 | +16,000 | 0.15 | 0.25 | +0.10 | buy |
| Merit Financial Group, LLC | 0 | 53,243 | +53,243 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 52,914 | +52,914 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 50,773 | +50,773 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 99,410 | 48,012 | -51,398 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 49,392 | 47,728 | -1,664 | 0.00 | 0.00 | +0.00 | sell |
| Private Advisor Group, LLC | 44,002 | 44,002 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Persistent Asset Partners Ltd | 0 | 42,645 | +42,645 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 33,652 | +33,652 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 121,899 | 29,286 | -92,613 | 0.01 | 0.00 | -0.01 | sell |
| Vanguard Personalized Indexing Management, LLC | 28,966 | 26,939 | -2,027 | 0.00 | 0.00 | +0.00 | sell |
| Ethos Financial Group, LLC | 0 | 23,697 | +23,697 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 25,700 | 23,300 | -2,400 | 0.00 | 0.00 | +0.00 | sell |
| BlueChip Wealth Advisors LLC | 0 | 23,000 | +23,000 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 14,171 | 22,426 | +8,255 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 27,698 | 18,109 | -9,589 | 0.03 | 0.06 | +0.02 | sell |
| Forefront Wealth Partners, LLC | 0 | 18,109 | +18,109 | 0.00 | 0.01 | +0.01 | buy |
| Truvestments Capital LLC | 14,868 | 17,101 | +2,233 | 0.01 | 0.01 | +0.00 | buy |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BIT Capital GmbH | 0 | 16,285 | +16,285 | 0.00 | 0.00 | +0.00 | buy |
| PURSUE WEALTH PARTNERS LLC | 14,492 | 14,492 | 0 | 0.02 | 0.03 | +0.01 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 12,435 | 14,121 | +1,686 | 0.00 | 0.00 | +0.00 | buy |
| Nierenberg Investment Management Company, Inc. | 12,555 | 12,555 | 0 | 0.02 | 0.02 | +0.01 | hold |
| IPG Investment Advisors LLC | 12,500 | 12,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TRUIST FINANCIAL CORP | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Bay Colony Advisory Group, Inc d/b/a Bay Colony Advisors | 0 | 10,747 | +10,747 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 10,250 | +10,250 | 0.00 | 0.00 | +0.00 | buy |
| Peregrine Asset Advisers, Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Meridian Wealth Management, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 7,970 | +7,970 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 7,756 | +7,756 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Asset Management, LLC | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 2 | 1,490 | +1,488 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,656 | 689 | -967 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 0 | 274 | +274 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 84 | 85 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 398 | 0 | -398 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 126,000 | 0 | -126,000 | 0.01 | 0.00 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 43,316 | 0 | -43,316 | 0.00 | 0.00 | -0.00 | sell |