| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 15,396,200 | 24,688,109 | +9,291,909 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 15,561,500 | 15,561,500 | 0 | 2.79 | 3.27 | +0.48 | hold |
| PERCEPTIVE ADVISORS LLC | 9,680,185 | 9,680,185 | 0 | 0.89 | 0.76 | -0.14 | hold |
| Kynam Capital Management, LP | 3,646,503 | 8,966,077 | +5,319,574 | 0.87 | 2.49 | +1.62 | buy |
| VANGUARD GROUP INC | 8,947,807 | 8,475,584 | -472,223 | 0.00 | 0.00 | +0.00 | sell |
| Commodore Capital LP | 7,692,300 | 7,692,300 | 0 | 1.20 | 2.18 | +0.98 | hold |
| Point72 Asset Management, L.P. | 4,068,575 | 5,189,538 | +1,120,963 | 0.03 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 644,982 | 5,140,931 | +4,495,949 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,250,826 | 4,250,826 | 0 | 0.10 | 0.11 | +0.01 | hold |
| ADAR1 Capital Management, LLC | 4,045,414 | 4,182,769 | +137,355 | 1.28 | 1.33 | +0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,913,081 | 3,872,202 | -40,879 | 0.03 | 0.03 | +0.01 | sell |
| Financial Engines Advisors L.L.C. | 1,381,357 | 3,828,717 | +2,447,360 | 0.01 | 0.03 | +0.02 | buy |
| BlackRock, Inc. | 2,381,912 | 3,669,393 | +1,287,481 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 8,461,500 | 3,525,650 | -4,935,850 | 0.65 | 0.31 | -0.34 | sell |
| Ikarian Capital, LLC | 3,372,616 | 3,172,616 | -200,000 | 2.18 | 1.75 | -0.43 | sell |
| Vivo Capital, LLC | 2,884,615 | 2,884,615 | 0 | 0.74 | 0.79 | +0.05 | hold |
| Eversept Partners, LP | 0 | 2,507,090 | +2,507,090 | 0.00 | 0.60 | +0.60 | buy |
| GOLDMAN SACHS GROUP INC | 447,753 | 2,460,944 | +2,013,191 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,337,005 | 2,337,005 | 0 | 0.04 | 0.04 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 729,698 | 1,560,755 | +831,057 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,569,298 | 1,525,666 | -43,632 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 451,128 | 1,289,656 | +838,528 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,104,993 | 1,156,936 | +51,943 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 122,500 | 1,061,128 | +938,628 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 1,036,311 | +1,036,311 | 0.00 | 0.76 | +0.76 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,485 | 981,598 | +714,113 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,237,057 | 894,663 | -342,394 | 0.10 | 0.10 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,005,228 | 876,305 | -128,923 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 653,725 | 856,056 | +202,331 | 0.00 | 0.01 | +0.00 | buy |
| Exome Asset Management LLC | 745,305 | 745,305 | 0 | 1.57 | 1.57 | -0.00 | hold |
| JANE STREET GROUP, LLC | 401,367 | 607,218 | +205,851 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 729,967 | 592,696 | -137,271 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 401,891 | 423,168 | +21,277 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 389,685 | 415,178 | +25,493 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 401,191 | +401,191 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 385,974 | +385,974 | 0.00 | 0.24 | +0.24 | buy |
| SCHULHOFF & CO INC | 0 | 374,850 | +374,850 | 0.00 | 0.67 | +0.67 | buy |
| UBS Group AG | 0 | 370,739 | +370,739 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,800,435 | 342,304 | -1,458,131 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1,490 | 336,525 | +335,035 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 40,000 | 335,524 | +295,524 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 252,659 | 328,248 | +75,589 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 293,560 | 316,971 | +23,411 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,386,863 | 289,653 | -1,097,210 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 273,584 | +273,584 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 158,329 | 229,599 | +71,270 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 206,526 | 206,526 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Informed Momentum Co LLC | 0 | 203,823 | +203,823 | 0.00 | 0.10 | +0.10 | buy |
| HighVista Strategies LLC | 257,148 | 193,941 | -63,207 | 0.20 | 0.21 | +0.01 | sell |
| SEI INVESTMENTS CO | 0 | 124,124 | +124,124 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 86,653 | 113,440 | +26,787 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 104,200 | +104,200 | 0.00 | 0.00 | +0.00 | buy |
| Aspire Growth Partners LLC | 102,254 | 102,254 | 0 | 0.24 | 0.30 | +0.06 | hold |
| PROFUND ADVISORS LLC | 0 | 98,633 | +98,633 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 7,756 | 96,326 | +88,570 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 87,800 | +87,800 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 535,974 | 81,886 | -454,088 | 0.14 | 0.03 | -0.11 | sell |
| Velan Capital Investment Management LP | 80,000 | 80,000 | 0 | 0.24 | 0.20 | -0.04 | hold |
| HRT FINANCIAL LP | 0 | 71,867 | +71,867 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,570 | 68,687 | -19,883 | 0.00 | 0.00 | +0.00 | sell |
| Miller Financial Services LLC | 67,000 | 68,000 | +1,000 | 0.25 | 0.34 | +0.09 | buy |
| Virtus Investment Advisers, LLC | 0 | 63,491 | +63,491 | 0.00 | 0.07 | +0.07 | buy |
| Brooklyn Investment Group | 87,160 | 61,474 | -25,686 | 0.03 | 0.01 | -0.02 | sell |
| Congress Park Capital LLC | 103,922 | 58,922 | -45,000 | 0.10 | 0.07 | -0.03 | sell |
| Merit Financial Group, LLC | 53,243 | 53,243 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 53,109 | +53,109 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 50,990 | +50,990 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 47,728 | 49,897 | +2,169 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 48,012 | 48,012 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 29,286 | 47,991 | +18,705 | 0.00 | 0.01 | +0.00 | buy |
| Formidable Asset Management, LLC | 118,337 | 45,763 | -72,574 | 0.06 | 0.03 | -0.03 | sell |
| Tidal Investments LLC | 118,337 | 45,763 | -72,574 | 0.00 | 0.00 | -0.00 | sell |
| Baader Bank Aktiengesellschaft | 0 | 45,000 | +45,000 | 0.00 | 0.02 | +0.02 | buy |
| Private Advisor Group, LLC | 44,002 | 44,002 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lighthouse Investment Partners, LLC | 0 | 32,040 | +32,040 | 0.00 | 0.00 | +0.00 | buy |
| Cambria Investment Management, L.P. | 0 | 31,332 | +31,332 | 0.00 | 0.01 | +0.01 | buy |
| Empowered Funds, LLC | 0 | 31,332 | +31,332 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 27,609 | +27,609 | 0.00 | 0.01 | +0.01 | buy |
| Truvestments Capital LLC | 17,101 | 27,428 | +10,327 | 0.01 | 0.02 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 26,939 | 26,765 | -174 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 26,539 | +26,539 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 26,265 | +26,265 | 0.00 | 0.01 | +0.01 | buy |
| HB Wealth Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 24,794 | +24,794 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 24,363 | +24,363 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 24,051 | +24,051 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 52,914 | 23,764 | -29,150 | 0.00 | 0.00 | -0.00 | sell |
| Ethos Financial Group, LLC | 23,697 | 23,697 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Mariner, LLC | 10,250 | 22,180 | +11,930 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 22,426 | 21,976 | -450 | 0.00 | 0.00 | +0.00 | sell |
| State of Wyoming | 0 | 21,511 | +21,511 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 33,652 | 21,212 | -12,440 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 19,410 | +19,410 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 18,109 | 18,699 | +590 | 0.06 | 0.07 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 17,600 | +17,600 | 0.00 | 0.01 | +0.01 | buy |
| WestHill Financial Advisors, Inc. | 17,082 | 17,082 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 15,959 | +15,959 | 0.00 | 0.00 | +0.00 | buy |
| PACES FERRY WEALTH ADVISORS, LLC | 0 | 14,822 | +14,822 | 0.00 | 0.03 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 14,121 | 14,722 | +601 | 0.00 | 0.00 | +0.00 | buy |
| PURSUE WEALTH PARTNERS LLC | 14,492 | 14,492 | 0 | 0.03 | 0.03 | +0.00 | hold |