| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AMERIPRISE FINANCIAL INC | 4,243,512 | 4,996,073 | +752,561 | 0.01 | 0.01 | +0.00 | buy |
| Portolan Capital Management, LLC | 4,259,851 | 4,525,553 | +265,702 | 1.25 | 1.54 | +0.29 | buy |
| BlackRock, Inc. | 3,112,980 | 3,375,910 | +262,930 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,647,515 | 2,677,833 | +30,318 | 0.00 | 0.00 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 957,747 | 2,092,147 | +1,134,400 | 4.74 | 8.35 | +3.61 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,315,280 | 2,046,449 | +731,169 | 0.02 | 0.04 | +0.02 | buy |
| Invenomic Capital Management LP | 1,393,005 | 1,505,208 | +112,203 | 0.40 | 0.46 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,011,890 | 1,073,967 | +62,077 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 819,534 | 893,401 | +73,867 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 806,263 | 822,998 | +16,735 | 0.00 | 0.00 | +0.00 | buy |
| Trium Capital LLP | 688,597 | 817,451 | +128,854 | 1.47 | 4.04 | +2.57 | buy |
| Williams Jones Wealth Management, LLC. | 686,464 | 638,939 | -47,525 | 0.04 | 0.05 | +0.00 | sell |
| Empire Financial Management Company, LLC | 452,430 | 617,830 | +165,400 | 0.56 | 0.85 | +0.29 | buy |
| EASTERLY INVESTMENT PARTNERS LLC | 1,252,184 | 616,681 | -635,503 | 0.46 | 0.24 | -0.22 | sell |
| Tikvah Management LLC | 571,619 | 571,619 | 0 | 0.92 | 0.97 | +0.06 | hold |
| First Eagle Investment Management, LLC | 0 | 531,427 | +531,427 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,209,199 | 402,631 | -806,568 | 0.01 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 707,071 | 389,466 | -317,605 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 331,246 | 362,740 | +31,494 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 353,658 | 345,564 | -8,094 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 252,211 | 328,956 | +76,745 | 0.15 | 0.20 | +0.05 | buy |
| UBS Group AG | 373,600 | 311,499 | -62,101 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 250,074 | 258,858 | +8,784 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 434,060 | 256,140 | -177,920 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 515,861 | 252,211 | -263,650 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 278,075 | 248,242 | -29,833 | 0.00 | 0.00 | +0.00 | sell |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 194,074 | 172,330 | -21,744 | 0.46 | 0.46 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 169,695 | +169,695 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 150,327 | 168,430 | +18,103 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 144,318 | 162,686 | +18,368 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 117,133 | 159,907 | +42,774 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 608,708 | 155,169 | -453,539 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 195,759 | 147,824 | -47,935 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 118,352 | 144,095 | +25,743 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 117,538 | 123,521 | +5,983 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 121,525 | +121,525 | 0.00 | 0.07 | +0.07 | buy |
| BARCLAYS PLC | 67,269 | 120,203 | +52,934 | 0.00 | 0.00 | +0.00 | buy |
| SCS Capital Management LLC | 120,035 | 120,035 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JPMORGAN CHASE & CO | 227,771 | 114,021 | -113,750 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 98,692 | 113,200 | +14,508 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 218,578 | 112,380 | -106,198 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 564,581 | 104,039 | -460,542 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 141,969 | 103,638 | -38,331 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 97,597 | 103,208 | +5,611 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 247,678 | 101,001 | -146,677 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 83,181 | 98,572 | +15,391 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 142,190 | 86,890 | -55,300 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 11,310 | 74,093 | +62,783 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 71,455 | 71,455 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 149,779 | 69,383 | -80,396 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 157,975 | 65,522 | -92,453 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 27,510 | 63,791 | +36,281 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 62,060 | 62,060 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 136,575 | 61,722 | -74,853 | 0.01 | 0.00 | -0.00 | sell |
| Mount Lucas Management LP | 60,000 | 56,500 | -3,500 | 0.15 | 0.16 | +0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 97,669 | 55,150 | -42,519 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 57,057 | 55,114 | -1,943 | 0.00 | 0.00 | +0.00 | sell |
| PEDDOCK CAPITAL ADVISORS, LLC | 52,105 | 52,105 | 0 | 0.06 | 0.07 | +0.01 | hold |
| PDT Partners, LLC | 47,668 | 47,668 | 0 | 0.02 | 0.02 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 45,627 | +45,627 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 44,480 | 44,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,778 | 43,778 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43,000 | 43,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 34,978 | +34,978 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 28,089 | 29,906 | +1,817 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 88,064 | 29,762 | -58,302 | 0.07 | 0.02 | -0.04 | sell |
| PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 100,671 | 25,000 | -75,671 | 0.97 | 0.33 | -0.65 | sell |
| ExodusPoint Capital Management, LP | 0 | 24,080 | +24,080 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 24,736 | 23,221 | -1,515 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 21,707 | +21,707 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 20,626 | +20,626 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,109 | 20,476 | +1,367 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,161 | 19,065 | -96 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 23,244 | 16,800 | -6,444 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 22,942 | 15,967 | -6,975 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 14,103 | 15,560 | +1,457 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,801 | 14,128 | +327 | 0.00 | 0.00 | +0.00 | buy |
| HUB Investment Partners, LLC | 12,161 | 13,661 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,008 | 13,172 | +164 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,018 | +13,018 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 17,377 | 12,677 | -4,700 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 11,800 | +11,800 | 0.00 | 0.00 | +0.00 | buy |
| Post Resch Tallon Group Inc. | 12,075 | 11,575 | -500 | 0.06 | 0.06 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 17,465 | 11,238 | -6,227 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 0 | 11,009 | +11,009 | 0.00 | 0.02 | +0.02 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,062 | 10,062 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,501 | 6,501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 39 | 6,357 | +6,318 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 4,566 | 4,566 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 4,078 | +4,078 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,307 | 3,993 | +686 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,475 | 3,475 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,538 | 2,718 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 2,579 | 2,323 | -256 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 1,294 | 1,952 | +658 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 1,421 | 1,778 | +357 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,028 | 1,620 | -1,408 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 2,463 | 1,513 | -950 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,189 | 1,387 | +198 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 1,100 | 1,100 | 0 | 0.00 | 0.00 | -0.00 | hold |