| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 0 | 1,950,000 | +1,950,000 | 0.00 | 0.63 | +0.63 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,917,354 | +1,917,354 | 0.00 | 0.11 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 421,322 | 1,806,322 | +1,385,000 | 0.00 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 947,579 | +947,579 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 142,984 | 897,709 | +754,725 | 0.19 | 1.04 | +0.86 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 420,571 | +420,571 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 134,566 | 463,741 | +329,175 | 0.29 | 0.52 | +0.24 | buy |
| ACORN CAPITAL ADVISORS, LLC | 0 | 287,826 | +287,826 | 0.00 | 0.46 | +0.46 | buy |
| Eversept Partners, LP | 0 | 276,174 | +276,174 | 0.00 | 0.10 | +0.10 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 3,726 | 248,957 | +245,231 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 41,733 | 257,903 | +216,170 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 212,367 | +212,367 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 53,816 | 262,146 | +208,330 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 544,554 | 733,435 | +188,881 | 0.52 | 0.58 | +0.07 | buy |
| XTX Topco Ltd | 11,904 | 164,443 | +152,539 | 0.00 | 0.02 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 112,432 | +112,432 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 88,455 | 194,017 | +105,562 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 102,419 | 191,527 | +89,108 | 0.02 | 0.04 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 50,000 | 136,736 | +86,736 | 0.03 | 0.05 | +0.02 | buy |
| Birchview Capital, LP | 0 | 83,952 | +83,952 | 0.00 | 0.27 | +0.27 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 70,748 | +70,748 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 35,533 | 105,901 | +70,368 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 144,628 | 213,810 | +69,182 | 0.03 | 0.03 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 52,984 | +52,984 | 0.00 | 0.06 | +0.06 | buy |
| T. Rowe Price Investment Management, Inc. | 1,491,409 | 1,542,090 | +50,681 | 0.01 | 0.01 | -0.00 | buy |
| Boxer Capital Management, LLC | 252,536 | 302,536 | +50,000 | 0.41 | 0.22 | -0.19 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 59,914 | 105,414 | +45,500 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 37,500 | +37,500 | 0.00 | 0.01 | +0.01 | buy |
| Centiva Capital, LP | 0 | 30,210 | +30,210 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 25,021 | +25,021 | 0.00 | 0.00 | +0.00 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 40,000 | 65,000 | +25,000 | 0.04 | 0.07 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 57,212 | 79,081 | +21,869 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 58,942 | 80,742 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,400 | +19,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 187,734 | 206,133 | +18,399 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 0 | 16,738 | +16,738 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 13,429 | +13,429 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 11,495 | +11,495 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 29,023 | 38,556 | +9,533 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 65,873 | 71,873 | +6,000 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 1 | 4,941 | +4,940 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 4,109 | 7,424 | +3,315 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 148,793 | 151,232 | +2,439 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 58,000 | 60,399 | +2,399 | 0.00 | 0.00 | -0.00 | buy |
| Baird Financial Group, Inc. | 27,993 | 29,791 | +1,798 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 11,087 | 11,399 | +312 | 0.00 | 0.00 | -0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 85 | 285 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 82 | 84 | +2 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 128,451 | 128,451 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| C WorldWide Group Holding A/S | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| West Branch Capital LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 733 | 733 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Soleus Capital Management, L.P. | 440,000 | 440,000 | 0 | 0.14 | 0.10 | -0.04 | hold |
| Activest Wealth Management | 66 | 66 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quent Capital, LLC | 235 | 235 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 3,203 | 3,203 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,886 | 10,886 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 74 | 67 | -7 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 679 | 665 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Aspect Partners, LLC | 391 | 0 | -391 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 247,558 | 244,899 | -2,659 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 51,000 | 45,800 | -5,200 | 0.09 | 0.06 | -0.03 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 310,020 | 300,000 | -10,020 | 0.03 | 0.03 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 12,922 | 0 | -12,922 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 18,316 | 0 | -18,316 | 0.06 | 0.00 | -0.06 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,723 | 0 | -28,723 | 0.02 | 0.00 | -0.02 | sell |
| CITADEL ADVISORS LLC | 31,709 | 0 | -31,709 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 32,868 | 0 | -32,868 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 59,708 | 0 | -59,708 | 0.00 | 0.00 | -0.00 | sell |
| Context Capital Management, LLC | 62,995 | 0 | -62,995 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 89,729 | 0 | -89,729 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 95,672 | 0 | -95,672 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,698 | 0 | -147,698 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 276,881 | 0 | -276,881 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 295,541 | 0 | -295,541 | 1.07 | 0.00 | -1.07 | sell |
| BRAIDWELL LP | 303,370 | 0 | -303,370 | 0.07 | 0.00 | -0.07 | sell |
| Affinity Asset Advisors, LLC | 889,575 | 500,000 | -389,575 | 0.47 | 0.16 | -0.31 | sell |
| Opaleye Management Inc. | 930,000 | 0 | -930,000 | 0.90 | 0.00 | -0.90 | sell |