| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 930,000 | +930,000 | 0.00 | 0.90 | +0.90 | buy |
| Affinity Asset Advisors, LLC | 0 | 889,575 | +889,575 | 0.00 | 0.47 | +0.47 | buy |
| T. Rowe Price Investment Management, Inc. | 700,992 | 1,491,409 | +790,417 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 27,257 | 544,554 | +517,297 | 0.04 | 0.52 | +0.48 | buy |
| Soleus Capital Management, L.P. | 0 | 440,000 | +440,000 | 0.00 | 0.14 | +0.14 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 310,020 | +310,020 | 0.00 | 0.03 | +0.03 | buy |
| BRAIDWELL LP | 0 | 303,370 | +303,370 | 0.00 | 0.07 | +0.07 | buy |
| Exome Asset Management LLC | 0 | 295,541 | +295,541 | 0.00 | 1.07 | +1.07 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 276,881 | +276,881 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 252,536 | +252,536 | 0.00 | 0.41 | +0.41 | buy |
| VANGUARD GROUP INC | 408,222 | 559,619 | +151,397 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 148,793 | +148,793 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 144,628 | +144,628 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,339 | 147,698 | +112,359 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 95,672 | +95,672 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 93,289 | 187,734 | +94,445 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 89,729 | +89,729 | 0.00 | 0.00 | +0.00 | buy |
| Context Capital Management, LLC | 0 | 62,995 | +62,995 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 59,708 | +59,708 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 58,000 | +58,000 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 57,212 | +57,212 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 53,816 | +53,816 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 51,000 | +51,000 | 0.00 | 0.09 | +0.09 | buy |
| Trexquant Investment LP | 0 | 41,733 | +41,733 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 35,533 | +35,533 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 68,436 | 102,419 | +33,983 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 31,709 | +31,709 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 34,873 | 65,873 | +31,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 59,685 | 88,455 | +28,770 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 28,723 | +28,723 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 5,862 | 32,868 | +27,006 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 25,000 | 50,000 | +25,000 | 0.02 | 0.03 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 18,316 | +18,316 | 0.00 | 0.06 | +0.06 | buy |
| BlackRock, Inc. | 231,951 | 247,558 | +15,607 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 12,922 | +12,922 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 46,342 | 58,942 | +12,600 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 18,876 | 29,023 | +10,147 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,726 | +3,726 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 25,932 | 27,993 | +2,061 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 733 | +733 | 0.00 | 0.00 | +0.00 | buy |
| Aspect Partners, LLC | 0 | 391 | +391 | 0.00 | 0.00 | +0.00 | buy |
| Quent Capital, LLC | 231 | 235 | +4 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 11,086 | 11,087 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 421,322 | 421,322 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 82 | 82 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SILVERBACK ASSET MANAGEMENT LLC | 40,000 | 40,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| CIBC Private Wealth Group LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 128,451 | 128,451 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |
| C WorldWide Group Holding A/S | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| West Branch Capital LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avidity Partners Management LP | 134,566 | 134,566 | 0 | 0.20 | 0.29 | +0.09 | hold |
| SBI Securities Co., Ltd. | 74 | 74 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 66 | 66 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalio Capital Management, LP | 142,984 | 142,984 | 0 | 0.17 | 0.19 | +0.01 | hold |
| TD Waterhouse Canada Inc. | 3,203 | 3,203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 4,109 | 4,109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 679 | 679 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,886 | 10,886 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 85 | 85 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PITTENGER & ANDERSON INC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Bruce G. Allen Investments, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 81 | 0 | -81 | 0.00 | 0.00 | -0.00 | sell |
| Rise Advisors, LLC | 131 | 0 | -131 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 513 | 1 | -512 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,089 | 0 | -1,089 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,402 | 11,904 | -2,498 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 64,714 | 59,914 | -4,800 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 14,076 | 0 | -14,076 | 0.01 | 0.00 | -0.01 | sell |
| Belvedere Trading LLC | 14,563 | 0 | -14,563 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 24,885 | 0 | -24,885 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 27,985 | 0 | -27,985 | 0.14 | 0.00 | -0.14 | sell |