| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 0 | 1,600,000 | +1,600,000 | 0.00 | 0.66 | +0.66 | buy |
| Nantahala Capital Management, LLC | 1,537,707 | 3,022,947 | +1,485,240 | 0.15 | 0.76 | +0.60 | buy |
| Velan Capital Investment Management LP | 0 | 400,000 | +400,000 | 0.00 | 0.55 | +0.55 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 51,406 | 330,081 | +278,675 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.48 | +0.48 | buy |
| VANGUARD GROUP INC | 1,407,652 | 1,553,352 | +145,700 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 90,346 | +90,346 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 262,649 | 337,190 | +74,541 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 346,549 | 398,423 | +51,874 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 601,259 | 626,259 | +25,000 | 0.02 | 0.05 | +0.03 | buy |
| Virtu Financial LLC | 0 | 14,410 | +14,410 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 11,640 | +11,640 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,011 | +11,011 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 18,219 | 20,914 | +2,695 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 10,154,327 | 10,154,327 | 0 | 0.03 | 0.06 | +0.03 | hold |
| BVF INC/IL | 190,815 | 190,815 | 0 | 0.00 | 0.01 | +0.01 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,690 | 631,690 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAXTON CORP | 1,318,967 | 1,318,967 | 0 | 7.07 | 19.16 | +12.10 | hold |
| Blackstone Inc. | 1,537,684 | 1,537,684 | 0 | 0.01 | 0.02 | +0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 996,710 | 996,710 | 0 | 0.18 | 0.41 | +0.23 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,757 | 13,757 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 59,572 | 59,572 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 157,085 | 151,985 | -5,100 | 0.05 | 0.11 | +0.06 | sell |
| Tower Research Capital LLC (TRC) | 11,335 | 4,886 | -6,449 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 83,986 | 67,226 | -16,760 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 26,988 | 0 | -26,988 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 217,902 | 0 | -217,902 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 3,242,842 | 2,797,704 | -445,138 | 0.26 | 0.56 | +0.30 | sell |
| Stonepine Capital Management, LLC | 2,768,656 | 121,479 | -2,647,177 | 1.19 | 0.25 | -0.94 | sell |
| FIRST MANHATTAN CO. LLC. | 2,680,978 | 0 | -2,680,978 | 0.01 | 0.00 | -0.01 | sell |