| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 6,507,718 | +6,507,718 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 843,144 | 1,845,247 | +1,002,103 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 210,068 | 732,197 | +522,129 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 90,465 | 572,695 | +482,230 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 89,700 | 378,800 | +289,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 331,799 | 616,515 | +284,716 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 236,209 | +236,209 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 621,894 | 833,042 | +211,148 | 1.44 | 1.31 | -0.12 | buy |
| Cubist Systematic Strategies, LLC | 48,365 | 210,581 | +162,216 | 0.00 | 0.01 | +0.00 | buy |
| Caligan Partners LP | 0 | 141,309 | +141,309 | 0.00 | 0.09 | +0.09 | buy |
| Squarepoint Ops LLC | 19,002 | 152,350 | +133,348 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,575,000 | 1,700,000 | +125,000 | 1.21 | 0.77 | -0.43 | buy |
| HRT FINANCIAL LP | 0 | 79,823 | +79,823 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 77,500 | +77,500 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 185,768 | 254,479 | +68,711 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 71,932 | 133,610 | +61,678 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,321,006 | 2,375,378 | +54,372 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 517,014 | 567,209 | +50,195 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 554,879 | 605,042 | +50,163 | 0.01 | 0.00 | -0.00 | buy |
| Jain Global LLC | 0 | 49,247 | +49,247 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 135,963 | 180,059 | +44,096 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 64,133 | 108,063 | +43,930 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 76,000 | 118,900 | +42,900 | 0.00 | 0.00 | -0.00 | buy |
| Quantessence Capital LLC | 0 | 34,533 | +34,533 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 893,601 | 926,657 | +33,056 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 32,599 | +32,599 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 31,300 | +31,300 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 24,123 | +24,123 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 21,846 | +21,846 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 21,646 | +21,646 | 0.00 | 0.07 | +0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 19,223 | +19,223 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 178,572 | 197,672 | +19,100 | 0.00 | 0.00 | -0.00 | buy |
| Paloma Partners Management Co | 0 | 16,601 | +16,601 | 0.00 | 0.01 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 31,411 | 47,301 | +15,890 | 0.07 | 0.06 | -0.01 | buy |
| BlackRock, Inc. | 432,056 | 447,301 | +15,245 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 34,311 | 47,557 | +13,246 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 12,439 | +12,439 | 0.00 | 0.00 | +0.00 | buy |
| JEPPSON WEALTH MANAGEMENT, LLC | 0 | 12,001 | +12,001 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 11,318 | +11,318 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 10,779 | +10,779 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 94,961 | 103,776 | +8,815 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 307,610 | 315,900 | +8,290 | 0.00 | 0.00 | -0.00 | buy |
| MML INVESTORS SERVICES, LLC | 13,410 | 17,410 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 43,187 | 47,122 | +3,935 | 0.05 | 0.02 | -0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 64,591 | 67,925 | +3,334 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 47,307 | 49,902 | +2,595 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 19,799 | 21,327 | +1,528 | 0.03 | 0.02 | -0.01 | buy |
| Point72 (DIFC) Ltd | 3,035 | 3,750 | +715 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 11,279,327 | 11,279,327 | 0 | 0.12 | 0.07 | -0.05 | hold |
| CAXTON CORP | 1,318,967 | 1,318,967 | 0 | 38.85 | 75.28 | +36.44 | hold |
| Blackstone Inc. | 1,744,740 | 1,744,740 | 0 | 0.04 | 0.02 | -0.02 | hold |
| J. Goldman & Co LP | 232,627 | 232,627 | 0 | 0.04 | 0.02 | -0.02 | hold |
| Opaleye Management Inc. | 465,000 | 465,000 | 0 | 0.40 | 0.30 | -0.10 | hold |
| NewEdge Advisors, LLC | 3,750 | 3,750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Europe (London) LLP | 146,932 | 146,932 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Integral Health Asset Management, LLC | 500,000 | 500,000 | 0 | 0.22 | 0.16 | -0.06 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,757 | 22,757 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 163 | 151 | -12 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,645 | 32 | -1,613 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 2,680 | 0 | -2,680 | 0.01 | 0.00 | -0.01 | sell |
| BFSG, LLC | 3,220 | 0 | -3,220 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 46,850 | 43,086 | -3,764 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,761 | 0 | -4,761 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,831 | 0 | -10,831 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 11,057 | 0 | -11,057 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 59,463 | 42,531 | -16,932 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 526,223 | 502,908 | -23,315 | 0.06 | 0.03 | -0.03 | sell |
| Aster Capital Management (DIFC) Ltd | 25,078 | 0 | -25,078 | 0.05 | 0.00 | -0.05 | sell |
| ExodusPoint Capital Management, LP | 56,573 | 18,246 | -38,327 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 1,089,345 | 1,028,211 | -61,134 | 0.04 | 0.02 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 69,724 | 0 | -69,724 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 69,989 | 0 | -69,989 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 85,431 | 3,638 | -81,793 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,165,895 | 1,081,447 | -84,448 | 1.06 | 0.77 | -0.28 | sell |
| Man Group plc | 86,640 | 0 | -86,640 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 123,184 | 0 | -123,184 | 0.53 | 0.00 | -0.53 | sell |
| 683 Capital Management, LLC | 128,668 | 0 | -128,668 | 0.06 | 0.00 | -0.06 | sell |
| CITADEL ADVISORS LLC | 319,632 | 109,591 | -210,041 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 247,431 | 14,449 | -232,982 | 0.04 | 0.00 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 1,359,208 | 1,116,047 | -243,161 | 1.37 | 0.62 | -0.75 | sell |
| Velan Capital Investment Management LP | 800,000 | 400,000 | -400,000 | 3.38 | 1.19 | -2.19 | sell |
| Walleye Capital LLC | 491,466 | 33,605 | -457,861 | 0.02 | 0.00 | -0.02 | sell |
| Vivo Capital, LLC | 2,797,704 | 2,112,432 | -685,272 | 1.54 | 0.81 | -0.72 | sell |
| Ikarian Capital, LLC | 857,230 | 50,058 | -807,172 | 1.20 | 0.05 | -1.15 | sell |
| Altium Capital Management LLC | 1,694,000 | 303,949 | -1,390,051 | 2.59 | 2.56 | -0.03 | sell |
| Nantahala Capital Management, LLC | 2,857,982 | 1,291,395 | -1,566,587 | 0.98 | 0.31 | -0.67 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,525,883 | 0 | -2,525,883 | 0.02 | 0.00 | -0.02 | sell |