| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 16,534,712 | 12,990,659 | -3,544,053 | 0.07 | 0.06 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 9,180,000 | 9,180,000 | 0 | 0.22 | 0.30 | +0.07 | hold |
| BlackRock, Inc. | 6,768,206 | 6,313,503 | -454,703 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 6,287,156 | 6,300,000 | +12,844 | 1.96 | 2.53 | +0.57 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 4,506,861 | 5,048,421 | +541,560 | 0.02 | 0.03 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 3,438,881 | +3,438,881 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 0 | 3,328,287 | +3,328,287 | 0.00 | 0.28 | +0.28 | buy |
| BANK OF AMERICA CORP /DE/ | 4,325,248 | 2,970,549 | -1,354,699 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,516,435 | 2,747,671 | +1,231,236 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 2,000,000 | 2,000,000 | 0 | 0.24 | 0.32 | +0.08 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,954,733 | 1,964,359 | +9,626 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 2,816,291 | 1,938,054 | -878,237 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 3,981,708 | 1,771,841 | -2,209,867 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 249,390 | 1,765,980 | +1,516,590 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 2,351,144 | 1,547,641 | -803,503 | 0.40 | 0.28 | -0.12 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,711,194 | 1,517,679 | -193,515 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 697,855 | 1,236,098 | +538,243 | 0.03 | 0.08 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 951,809 | 951,809 | 0 | 0.73 | 0.71 | -0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 830,588 | +830,588 | 0.00 | 0.00 | +0.00 | buy |
| 22NW, LP | 820,653 | 820,653 | 0 | 0.82 | 1.72 | +0.90 | hold |
| AQR CAPITAL MANAGEMENT LLC | 271,073 | 796,696 | +525,623 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 750,000 | 750,000 | 0 | 1.03 | 1.43 | +0.40 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 665,158 | 638,384 | -26,774 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 737,315 | 632,821 | -104,494 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 368,166 | 611,797 | +243,631 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,304,782 | 602,296 | -702,486 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 585,892 | +585,892 | 0.00 | 0.08 | +0.08 | buy |
| JANE STREET GROUP, LLC | 1,407,699 | 543,363 | -864,336 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 141,883 | 530,229 | +388,346 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,911,066 | 495,462 | -1,415,604 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 340,000 | 370,000 | +30,000 | 0.37 | 0.67 | +0.30 | buy |
| XTX Topco Ltd | 481,949 | 292,827 | -189,122 | 0.03 | 0.02 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 220,407 | +220,407 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 671,692 | 189,779 | -481,913 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 91,461 | 157,711 | +66,250 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 147,795 | 151,492 | +3,697 | 0.09 | 0.13 | +0.03 | buy |
| SEI INVESTMENTS CO | 37,897 | 146,576 | +108,679 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 141,889 | +141,889 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 206,265 | 128,726 | -77,539 | 0.05 | 0.04 | -0.01 | sell |
| CITADEL ADVISORS LLC | 0 | 115,404 | +115,404 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 114,329 | +114,329 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 374,068 | 102,274 | -271,794 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 97,686 | 97,686 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 95,702 | +95,702 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 95,968 | 88,380 | -7,588 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 10,510 | 88,226 | +77,716 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 77,000 | 87,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 81,000 | +81,000 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 76,143 | 78,021 | +1,878 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 27,676 | 66,195 | +38,519 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 63,723 | 64,211 | +488 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 38,679 | 58,679 | +20,000 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,088 | 57,585 | +12,497 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,305,568 | 57,366 | -2,248,202 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,649 | 55,800 | +53,151 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 52,568 | +52,568 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 47,752 | +47,752 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,553 | 46,111 | +39,558 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 149,952 | 44,004 | -105,948 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 43,870 | 43,870 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 42,229 | 42,094 | -135 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 45,425 | 40,324 | -5,101 | 0.00 | 0.00 | +0.00 | sell |
| Rangeley Capital, LLC | 78,200 | 40,000 | -38,200 | 0.16 | 0.13 | -0.03 | sell |
| Creative Planning | 0 | 39,463 | +39,463 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 12,762 | 36,939 | +24,177 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 35,127 | +35,127 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,084 | 33,957 | -11,127 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 35,301 | 33,769 | -1,532 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 29,554 | +29,554 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 29,283 | +29,283 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 89,649 | 27,434 | -62,215 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 25,779 | +25,779 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 14,625 | 24,625 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,600 | 24,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 24,183 | +24,183 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 21,800 | 21,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,831 | 20,512 | -5,319 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 43,819 | 20,117 | -23,702 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 0 | 19,923 | +19,923 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 18,300 | +18,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,264 | 17,803 | +9,539 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 16,479 | 16,479 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 22,680 | 16,385 | -6,295 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 46,413 | 16,232 | -30,181 | 0.01 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 0 | 14,229 | +14,229 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 14,130 | +14,130 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 11,073 | 13,522 | +2,449 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,776 | 12,776 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 14,630 | 12,350 | -2,280 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 14,757 | 10,494 | -4,263 | 0.00 | 0.00 | -0.00 | sell |
| JEPPSON WEALTH MANAGEMENT, LLC | 0 | 10,001 | +10,001 | 0.00 | 0.01 | +0.01 | buy |
| Auxano Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Legal & General Group Plc | 8,115 | 6,938 | -1,177 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,834 | 6,834 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,968 | 3,950 | -1,018 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 32,769 | 3,811 | -28,958 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 209,179 | 3,298 | -205,881 | 0.12 | 0.00 | -0.12 | sell |
| Tower Research Capital LLC (TRC) | 9,209 | 3,165 | -6,044 | 0.00 | 0.00 | -0.00 | sell |
| Pinnacle Wealth Planning Services, Inc. | 0 | 2,102 | +2,102 | 0.00 | 0.00 | +0.00 | buy |