| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 0 | 2,063,962 | +2,063,962 | 0.00 | 1.79 | +1.79 | buy |
| Altium Capital Management LLC | 0 | 1,700,000 | +1,700,000 | 0.00 | 3.02 | +3.02 | buy |
| FEDERATED HERMES, INC. | 10,154,327 | 11,279,327 | +1,125,000 | 0.06 | 0.11 | +0.06 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,089,767 | +1,089,767 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 1,047,230 | +1,047,230 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 903,744 | +903,744 | 0.00 | 1.21 | +1.21 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 996,710 | 1,707,999 | +711,289 | 0.41 | 1.20 | +0.79 | buy |
| MORGAN STANLEY | 0 | 400,246 | +400,246 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 400,000 | 800,000 | +400,000 | 0.55 | 1.97 | +1.42 | buy |
| Exome Asset Management LLC | 0 | 282,400 | +282,400 | 0.00 | 1.08 | +1.08 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 274,916 | +274,916 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 258,900 | +258,900 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 250,000 | +250,000 | 0.00 | 0.14 | +0.14 | buy |
| Affinity Asset Advisors, LLC | 1,600,000 | 1,850,000 | +250,000 | 0.66 | 1.25 | +0.59 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,000 | 258,750 | +246,750 | 0.00 | 0.03 | +0.03 | buy |
| Blackstone Inc. | 1,537,684 | 1,744,640 | +206,956 | 0.02 | 0.03 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 129,858 | +129,858 | 0.00 | 0.09 | +0.09 | buy |
| Walleye Capital LLC | 0 | 127,933 | +127,933 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 90,346 | 184,502 | +94,156 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 87,900 | +87,900 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 1,553,352 | 1,618,036 | +64,684 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 64,444 | +64,444 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 59,396 | +59,396 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 59,572 | 112,472 | +52,900 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 200,000 | 250,000 | +50,000 | 0.48 | 0.85 | +0.37 | buy |
| Cubist Systematic Strategies, LLC | 11,640 | 54,237 | +42,597 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,011 | 33,671 | +22,660 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 337,190 | 353,696 | +16,506 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 15,672 | +15,672 | 0.00 | 0.00 | +0.00 | buy |
| JEPPSON WEALTH MANAGEMENT, LLC | 0 | 10,510 | +10,510 | 0.00 | 0.02 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 10,058 | +10,058 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 3,750 | +3,750 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 14,410 | 16,475 | +2,065 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2 | 1,231 | +1,229 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 904 | +904 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 160 | +160 | 0.00 | 0.00 | 0.00 | buy |
| BVF INC/IL | 190,815 | 190,815 | 0 | 0.01 | 0.02 | +0.01 | hold |
| CAXTON CORP | 1,318,967 | 1,318,967 | 0 | 19.16 | 28.74 | +9.58 | hold |
| Vivo Capital, LLC | 2,797,704 | 2,797,704 | 0 | 0.56 | 1.11 | +0.55 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,757 | 13,757 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 67,226 | 67,182 | -44 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 20,914 | 17,651 | -3,263 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,886 | 0 | -4,886 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Advisory Services, LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 3,022,947 | 2,989,963 | -32,984 | 0.76 | 1.29 | +0.54 | sell |
| CITADEL ADVISORS LLC | 398,423 | 337,534 | -60,889 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 121,479 | 0 | -121,479 | 0.25 | 0.00 | -0.25 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 330,081 | 180,421 | -149,660 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 151,985 | 0 | -151,985 | 0.11 | 0.00 | -0.11 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 626,259 | 457,737 | -168,522 | 0.05 | 0.06 | +0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,690 | 315,845 | -315,845 | 0.00 | 0.00 | -0.00 | sell |