| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 833,042 | 3,033,462 | +2,200,420 | 1.28 | 8.80 | +7.52 | buy |
| Blackstone Inc. | 1,744,740 | 3,560,289 | +1,815,549 | 0.02 | 0.07 | +0.05 | buy |
| Caligan Partners LP | 141,309 | 1,543,014 | +1,401,705 | 0.09 | 1.34 | +1.25 | buy |
| Integral Health Asset Management, LLC | 500,000 | 1,800,000 | +1,300,000 | 0.16 | 0.75 | +0.59 | buy |
| Nantahala Capital Management, LLC | 1,291,395 | 2,291,395 | +1,000,000 | 0.15 | 0.40 | +0.25 | buy |
| Woodline Partners LP | 1,028,211 | 1,904,131 | +875,920 | 0.02 | 0.04 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 1,700,000 | 2,200,000 | +500,000 | 0.77 | 1.45 | +0.68 | buy |
| Opaleye Management Inc. | 465,000 | 903,442 | +438,442 | 0.30 | 0.82 | +0.52 | buy |
| Velan Capital Investment Management LP | 400,000 | 750,000 | +350,000 | 1.19 | 3.35 | +2.15 | buy |
| CAXTON CORP | 1,318,967 | 1,603,986 | +285,019 | 75.28 | 72.60 | -2.68 | buy |
| J. Goldman & Co LP | 232,627 | 486,000 | +253,373 | 0.02 | 0.05 | +0.04 | buy |
| Paloma Partners Management Co | 16,601 | 124,994 | +108,393 | 0.01 | 0.08 | +0.08 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 502,908 | 455,701 | +47,207 | 0.12 | 0.11 | 0.00 | sell |
| CANTOR FITZGERALD, L. P. | 77,500 | 119,963 | +42,463 | 0.00 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 12,439 | 24,504 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 47,122 | 49,122 | +2,000 | 0.02 | 0.02 | +0.01 | buy |
| Point72 Europe (London) LLP | 146,932 | 38,534 | -108,398 | 0.03 | 0.01 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 1,116,047 | 989,297 | -126,750 | 0.62 | 0.72 | +0.09 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,081,447 | 751,447 | -330,000 | 0.72 | 0.79 | +0.06 | sell |