| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 11,279,327 | 14,034,712 | +2,755,385 | 0.07 | 0.12 | +0.05 | buy |
| FMR LLC | 6,507,718 | 12,811,876 | +6,304,158 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 447,301 | 4,081,525 | +3,634,224 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,375,378 | 4,022,580 | +1,647,202 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 1,744,740 | 3,560,289 | +1,815,549 | 0.02 | 0.07 | +0.05 | buy |
| UBS Group AG | 616,515 | 3,037,168 | +2,420,653 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 833,042 | 3,033,462 | +2,200,420 | 1.31 | 8.80 | +7.48 | buy |
| MARSHALL WACE, LLP | 1,845,247 | 2,886,481 | +1,041,234 | 0.01 | 0.02 | +0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 2,297,489 | +2,297,489 | 0.00 | 1.10 | +1.10 | buy |
| Nantahala Capital Management, LLC | 1,291,395 | 2,291,395 | +1,000,000 | 0.31 | 0.72 | +0.41 | buy |
| Affinity Asset Advisors, LLC | 1,700,000 | 2,200,000 | +500,000 | 0.77 | 1.45 | +0.68 | buy |
| Vivo Capital, LLC | 2,112,432 | 2,112,432 | 0 | 0.81 | 0.96 | +0.15 | hold |
| Woodline Partners LP | 1,028,211 | 1,904,131 | +875,920 | 0.02 | 0.04 | +0.03 | buy |
| Integral Health Asset Management, LLC | 500,000 | 1,800,000 | +1,300,000 | 0.16 | 0.75 | +0.59 | buy |
| Rosalind Advisors, Inc. | 0 | 1,741,211 | +1,741,211 | 0.00 | 3.76 | +3.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 567,209 | 1,711,043 | +1,143,834 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 1,318,967 | 1,603,986 | +285,019 | 75.28 | 72.60 | -2.68 | buy |
| Caligan Partners LP | 141,309 | 1,543,014 | +1,401,705 | 0.09 | 1.34 | +1.25 | buy |
| ADAR1 Capital Management, LLC | 1,116,047 | 989,297 | -126,750 | 0.62 | 0.72 | +0.09 | sell |
| Opaleye Management Inc. | 465,000 | 903,442 | +438,442 | 0.30 | 0.82 | +0.52 | buy |
| STATE STREET CORP | 197,672 | 830,074 | +632,402 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,081,447 | 751,447 | -330,000 | 0.77 | 0.88 | +0.10 | sell |
| Velan Capital Investment Management LP | 400,000 | 750,000 | +350,000 | 1.19 | 3.35 | +2.15 | buy |
| STEMPOINT CAPITAL LP | 0 | 644,654 | +644,654 | 0.00 | 0.93 | +0.93 | buy |
| NORTHERN TRUST CORP | 103,776 | 591,847 | +488,071 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 232,627 | 486,000 | +253,373 | 0.02 | 0.07 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 502,908 | 455,701 | -47,207 | 0.03 | 0.06 | +0.02 | sell |
| PFM Health Sciences, LP | 0 | 434,134 | +434,134 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 108,063 | 398,535 | +290,472 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 14,449 | 266,671 | +252,222 | 0.00 | 0.04 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 261,411 | +261,411 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 233,000 | +233,000 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 254,479 | 220,932 | -33,547 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 219,000 | +219,000 | 0.00 | 0.96 | +0.96 | buy |
| Point72 Asset Management, L.P. | 0 | 211,509 | +211,509 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,757 | 203,581 | +180,824 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 172,886 | +172,886 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 140,767 | +140,767 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 16,601 | 124,994 | +108,393 | 0.01 | 0.13 | +0.12 | buy |
| CANTOR FITZGERALD, L. P. | 77,500 | 119,963 | +42,463 | 0.01 | 0.01 | +0.00 | buy |
| Allostery Investments LP | 0 | 119,294 | +119,294 | 0.00 | 6.78 | +6.78 | buy |
| Caption Management, LLC | 49,902 | 100,000 | +50,098 | 0.01 | 0.04 | +0.03 | buy |
| RHUMBLINE ADVISERS | 0 | 96,960 | +96,960 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 180,059 | 86,556 | -93,503 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 926,657 | 81,366 | -845,291 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 572,695 | 76,554 | -496,141 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 0 | 59,900 | +59,900 | 0.00 | 0.07 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 378,800 | 52,833 | -325,967 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 47,122 | 49,122 | +2,000 | 0.02 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 0 | 48,550 | +48,550 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 43,086 | 46,105 | +3,019 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 42,229 | +42,229 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 42,050 | +42,050 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 146,932 | 38,534 | -108,398 | 0.03 | 0.01 | -0.02 | sell |
| Invesco Ltd. | 0 | 38,485 | +38,485 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 38,348 | +38,348 | 0.00 | 0.05 | +0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 36,645 | +36,645 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 35,859 | +35,859 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 35,742 | +35,742 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 33,556 | +33,556 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 236,209 | 33,104 | -203,105 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 32,860 | +32,860 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 31,634 | +31,634 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 0 | 28,155 | +28,155 | 0.00 | 0.09 | +0.09 | buy |
| XTX Topco Ltd | 32,599 | 26,321 | -6,278 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 12,439 | 24,504 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 24,210 | +24,210 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 23,714 | +23,714 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,638 | 23,623 | +19,985 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 23,300 | +23,300 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 18,957 | +18,957 | 0.00 | 0.00 | +0.00 | buy |
| Retireful, LLC | 0 | 15,702 | +15,702 | 0.00 | 0.05 | +0.05 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 15,280 | +15,280 | 0.00 | 0.00 | +0.00 | buy |
| Huntleigh Advisors, Inc. | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 13,727 | +13,727 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,925 | 12,859 | -55,066 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 32 | 8,634 | +8,602 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 7,268 | +7,268 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 6,834 | +6,834 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 5,696 | +5,696 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 4,177 | +4,177 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 3,750 | 3,750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 0 | 3,048 | +3,048 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 2,286 | +2,286 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 200 | 560 | +360 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 388 | +388 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 151 | 151 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 0 | 100 | +100 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,223 | 0 | -19,223 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 118,900 | 0 | -118,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 42,531 | 0 | -42,531 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 47,557 | 0 | -47,557 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 732,197 | 0 | -732,197 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 109,591 | 0 | -109,591 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 11,318 | 0 | -11,318 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 47,301 | 0 | -47,301 | 0.06 | 0.00 | -0.06 | sell |
| Verition Fund Management LLC | 24,123 | 0 | -24,123 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 79,823 | 0 | -79,823 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 21,846 | 0 | -21,846 | 0.00 | 0.00 | -0.00 | sell |