| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 12,990,659 | 12,990,659 | 0 | 0.06 | 0.10 | +0.03 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,180,000 | 9,445,039 | +265,039 | 0.30 | 0.43 | +0.13 | buy |
| BlackRock, Inc. | 6,313,503 | 7,718,291 | +1,404,788 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 6,300,000 | 6,300,000 | 0 | 2.53 | 2.97 | +0.44 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 5,048,421 | 4,662,039 | -386,382 | 0.03 | 0.04 | +0.01 | sell |
| Siren, L.L.C. | 3,328,287 | 3,328,287 | 0 | 0.28 | 0.35 | +0.07 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 220,407 | 2,561,654 | +2,341,247 | 0.00 | 0.05 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 3,438,881 | 2,459,308 | -979,573 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,964,359 | 2,170,154 | +205,795 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,771,841 | 1,850,128 | +78,287 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,765,980 | 1,839,357 | +73,377 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 2,747,671 | 1,618,783 | -1,128,888 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 602,296 | 1,316,782 | +714,486 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 97,686 | 1,295,209 | +1,197,523 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,236,098 | 1,221,678 | -14,420 | 0.08 | 0.11 | +0.03 | sell |
| Blackstone Inc. | 0 | 1,082,927 | +1,082,927 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 796,696 | 1,007,962 | +211,266 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,547,641 | 1,000,000 | -547,641 | 0.28 | 0.25 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 951,809 | 951,809 | 0 | 0.71 | 1.17 | +0.46 | hold |
| Ikarian Capital, LLC | 16,479 | 935,012 | +918,533 | 0.01 | 0.80 | +0.79 | buy |
| DIMENSIONAL FUND ADVISORS LP | 530,229 | 890,733 | +360,504 | 0.00 | 0.00 | +0.00 | buy |
| 22NW, LP | 820,653 | 820,653 | 0 | 1.72 | 4.08 | +2.36 | hold |
| Velan Capital Investment Management LP | 750,000 | 750,000 | 0 | 1.43 | 2.39 | +0.96 | hold |
| BANK OF AMERICA CORP /DE/ | 2,970,549 | 730,332 | -2,240,217 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 632,821 | 725,271 | +92,450 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 723,588 | +723,588 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 638,384 | 723,588 | +85,204 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 611,797 | 611,797 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,517,679 | 517,234 | -1,000,445 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 585,892 | 500,405 | -85,487 | 0.08 | 0.09 | +0.01 | sell |
| Integral Health Asset Management, LLC | 2,000,000 | 500,000 | -1,500,000 | 0.32 | 0.11 | -0.22 | sell |
| UBS Group AG | 1,938,054 | 496,033 | -1,442,021 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 830,588 | 431,073 | -399,515 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 382,999 | +382,999 | 0.00 | 0.05 | +0.05 | buy |
| Knott David M Jr | 370,000 | 370,000 | 0 | 0.67 | 1.02 | +0.35 | hold |
| XTX Topco Ltd | 292,827 | 353,670 | +60,843 | 0.02 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 289,519 | +289,519 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 286,955 | +286,955 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 114,329 | 279,641 | +165,312 | 0.01 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 543,363 | 263,879 | -279,484 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 263,746 | +263,746 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 57,366 | 216,117 | +158,751 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 189,779 | 212,270 | +22,491 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 46,111 | 207,748 | +161,637 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 495,462 | 156,389 | -339,073 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 66,195 | 151,982 | +85,787 | 0.01 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 128,726 | 127,289 | -1,437 | 0.04 | 0.06 | +0.02 | sell |
| Creative Planning | 39,463 | 117,362 | +77,899 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 108,554 | +108,554 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 104,705 | +104,705 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 35,127 | 101,243 | +66,116 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 115,404 | 98,490 | -16,914 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 78,021 | 97,724 | +19,703 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 97,652 | +97,652 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 88,380 | 94,298 | +5,918 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 146,576 | 93,475 | -53,101 | 0.00 | 0.00 | +0.00 | sell |
| State of Alaska, Department of Revenue | 87,000 | 87,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 151,492 | 81,800 | -69,692 | 0.13 | 0.10 | -0.03 | sell |
| Jain Global LLC | 0 | 80,939 | +80,939 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 64,211 | 80,780 | +16,569 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 78,000 | +78,000 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 77,823 | +77,823 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 52,568 | 75,839 | +23,271 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 33,769 | 70,129 | +36,360 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 43,870 | 68,280 | +24,410 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,434 | 67,928 | +40,494 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,585 | 63,608 | +6,023 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 47,752 | 61,765 | +14,013 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 36,939 | 53,597 | +16,658 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 53,027 | +53,027 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 51,300 | +51,300 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 50,147 | +50,147 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 58,679 | 48,679 | -10,000 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 42,094 | 47,207 | +5,113 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 40,324 | 40,675 | +351 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 39,500 | +39,500 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,811 | 36,180 | +32,369 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,957 | 36,041 | +2,084 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 35,755 | +35,755 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 24,183 | 35,598 | +11,415 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 25,779 | 34,708 | +8,929 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 32,500 | +32,500 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 30,786 | +30,786 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 19,923 | 28,843 | +8,920 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 81,000 | 28,100 | -52,900 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 25,375 | +25,375 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 24,997 | +24,997 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 23,549 | +23,549 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 14,229 | 23,210 | +8,981 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 22,804 | +22,804 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,512 | 21,916 | +1,404 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 21,800 | 21,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rangeley Capital, LLC | 40,000 | 19,650 | -20,350 | 0.13 | 0.10 | -0.04 | sell |
| EntryPoint Capital, LLC | 0 | 19,462 | +19,462 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 20,117 | 18,776 | -1,341 | 0.00 | 0.00 | +0.00 | sell |
| WINTON GROUP Ltd | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,803 | 15,280 | -2,523 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,776 | 15,198 | +2,422 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,600 | 15,000 | -9,600 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 0 | 14,448 | +14,448 | 0.00 | 0.00 | +0.00 | buy |