| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 466,563 | +466,563 | 0.00 | 0.38 | +0.38 | buy |
| VANGUARD GROUP INC | 1,618,036 | 1,932,057 | +314,021 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 17,651 | 221,451 | +203,800 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 184,502 | 343,672 | +159,170 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 353,696 | 491,601 | +137,905 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,231 | 126,965 | +125,734 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 105,252 | +105,252 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 904 | 104,165 | +103,261 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 180,421 | 278,300 | +97,879 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 274,916 | 362,259 | +87,343 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 54,237 | 140,533 | +86,296 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 258,900 | 344,300 | +85,400 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,047,230 | 1,128,553 | +81,323 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 71,581 | +71,581 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 282,400 | 352,056 | +69,656 | 1.08 | 1.15 | +0.07 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 49,322 | +49,322 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 39,849 | +39,849 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 337,534 | 376,252 | +38,718 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 37,343 | +37,343 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 67,182 | 96,957 | +29,775 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 27,000 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 24,289 | +24,289 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 22,982 | +22,982 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 33,671 | 56,375 | +22,704 | 0.01 | 0.02 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 87,900 | 109,508 | +21,608 | 0.03 | 0.04 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 13,329 | +13,329 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 112,472 | 125,472 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 12,900 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 11,660 | +11,660 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 16,475 | 26,026 | +9,551 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 4,117 | +4,117 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 2,800 | +2,800 | 0.00 | 0.01 | +0.01 | buy |
| BFSG, LLC | 0 | 1,220 | +1,220 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 1,744,640 | 1,744,740 | +100 | 0.03 | 0.04 | +0.01 | buy |
| FEDERATED HERMES, INC. | 11,279,327 | 11,279,327 | 0 | 0.11 | 0.12 | +0.01 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 315,845 | 315,845 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAXTON CORP | 1,318,967 | 1,318,967 | 0 | 28.74 | 26.47 | -2.27 | hold |
| Informed Momentum Co LLC | 129,858 | 129,858 | 0 | 0.09 | 0.09 | +0.00 | hold |
| NewEdge Advisors, LLC | 3,750 | 3,750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 2,797,704 | 2,797,704 | 0 | 1.11 | 1.12 | +0.01 | hold |
| Altium Capital Management LLC | 1,700,000 | 1,700,000 | 0 | 3.02 | 2.46 | -0.56 | hold |
| Velan Capital Investment Management LP | 800,000 | 800,000 | 0 | 1.97 | 4.21 | +2.24 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,058 | 10,058 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,757 | 13,757 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 160 | 0 | -160 | 0.00 | 0.00 | 0.00 | sell |
| Frazier Financial Advisors, LLC | 550 | 0 | -550 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 59,396 | 57,578 | -1,818 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 258,750 | 256,090 | -2,660 | 0.03 | 0.04 | +0.00 | sell |
| JEPPSON WEALTH MANAGEMENT, LLC | 10,510 | 0 | -10,510 | 0.02 | 0.00 | -0.02 | sell |
| Verition Fund Management LLC | 15,672 | 0 | -15,672 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 903,744 | 887,230 | -16,514 | 1.21 | 1.34 | +0.12 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 457,737 | 439,233 | -18,504 | 0.06 | 0.05 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 64,444 | 0 | -64,444 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 127,933 | 0 | -127,933 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,850,000 | 1,700,000 | -150,000 | 1.25 | 1.28 | +0.03 | sell |
| BVF INC/IL | 190,815 | 0 | -190,815 | 0.02 | 0.00 | -0.02 | sell |
| Rosalind Advisors, Inc. | 250,000 | 0 | -250,000 | 0.85 | 0.00 | -0.85 | sell |
| Monashee Investment Management LLC | 250,000 | 0 | -250,000 | 0.14 | 0.00 | -0.14 | sell |
| MORGAN STANLEY | 400,246 | 0 | -400,246 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 2,989,963 | 2,577,121 | -412,842 | 1.29 | 1.05 | -0.24 | sell |
| ADAR1 Capital Management, LLC | 2,063,962 | 1,571,705 | -492,257 | 1.79 | 1.28 | -0.51 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,707,999 | 1,196,938 | -511,061 | 1.20 | 0.95 | -0.25 | sell |
| Alyeska Investment Group, L.P. | 1,089,767 | 0 | -1,089,767 | 0.03 | 0.00 | -0.03 | sell |