| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 6,610,274 | 10,154,327 | +3,544,053 | 0.02 | 0.03 | +0.00 | buy |
| Vivo Capital, LLC | 484,439 | 3,242,842 | +2,758,403 | 0.07 | 0.26 | +0.19 | buy |
| Nantahala Capital Management, LLC | 769,606 | 1,537,707 | +768,101 | 0.13 | 0.15 | +0.02 | buy |
| UBS Group AG | 0 | 217,902 | +217,902 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 557,307 | 601,259 | +43,952 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 316,264 | 346,549 | +30,285 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 25,700 | 51,406 | +25,706 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 18,219 | +18,219 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 11,335 | +11,335 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,407,652 | 1,407,652 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 190,815 | 190,815 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,690 | 631,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 262,649 | 262,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAXTON CORP | 1,318,967 | 1,318,967 | 0 | 6.61 | 7.07 | +0.45 | hold |
| Bank of New York Mellon Corp | 26,988 | 26,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 1,537,684 | 1,537,684 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 996,710 | 996,710 | 0 | 0.32 | 0.18 | -0.13 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,000 | 12,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,757 | 13,757 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 59,572 | 59,572 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 85,909 | 83,986 | -1,923 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 433,240 | 157,085 | -276,155 | 0.21 | 0.05 | -0.16 | sell |
| Stonepine Capital Management, LLC | 3,072,476 | 2,768,656 | -303,820 | 1.35 | 1.19 | -0.16 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 310,000 | 0 | -310,000 | 0.30 | 0.00 | -0.30 | sell |
| Velan Capital Investment Management LP | 400,000 | 0 | -400,000 | 0.43 | 0.00 | -0.43 | sell |
| FIRST MANHATTAN CO. LLC. | 3,623,078 | 2,680,978 | -942,100 | 0.02 | 0.01 | -0.01 | sell |