| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 315,845 | 2,525,883 | +2,210,038 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 37,343 | 1,089,345 | +1,052,002 | 0.00 | 0.04 | +0.03 | buy |
| Nantahala Capital Management, LLC | 2,577,121 | 2,857,982 | +280,861 | 0.63 | 0.60 | -0.03 | buy |
| Integral Health Asset Management, LLC | 250,000 | 500,000 | +250,000 | 0.14 | 0.21 | +0.07 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 439,233 | 526,223 | +86,990 | 0.17 | 0.21 | 0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 49,322 | 69,989 | +20,667 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 24,289 | 43,187 | +18,898 | 0.02 | 0.05 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 13,329 | 19,799 | +6,470 | 0.01 | 0.03 | +0.01 | buy |
| BFSG, LLC | 1,220 | 3,220 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 466,563 | 465,000 | -1,563 | 0.38 | 0.40 | +0.02 | sell |
| Altium Capital Management LLC | 1,700,000 | 1,694,000 | -6,000 | 2.46 | 2.59 | +0.13 | sell |
| Ikarian Capital, LLC | 887,230 | 857,230 | -30,000 | 0.60 | 0.57 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,196,938 | 1,165,895 | -31,043 | 0.92 | 1.03 | +0.11 | sell |
| Affinity Asset Advisors, LLC | 1,700,000 | 1,575,000 | -125,000 | 1.13 | 1.03 | -0.09 | sell |
| ADAR1 Capital Management, LLC | 1,571,705 | 1,359,208 | -212,497 | 1.28 | 1.37 | +0.09 | sell |