| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 127,541 | +127,541 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 334,713 | 409,804 | +75,091 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 602,203 | 669,303 | +67,100 | 0.25 | 0.43 | +0.18 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 62,850 | +62,850 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 143,677 | 203,960 | +60,283 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 54,000 | 101,567 | +47,567 | 0.01 | 0.05 | +0.04 | buy |
| CITADEL ADVISORS LLC | 644,219 | 682,749 | +38,530 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 27,713 | 63,213 | +35,500 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,926 | 23,844 | +18,918 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 28,146 | 44,558 | +16,412 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,450 | +14,450 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 13,400 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,001 | +13,001 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 2,666 | 3,078 | +412 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| TOMPKINS FINANCIAL CORP | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 24 | 24 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 942,918 | 942,918 | 0 | 0.00 | 0.01 | +0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 44,971 | 44,971 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,172,175 | 1,172,175 | 0 | 0.01 | 0.06 | +0.05 | hold |
| Allworth Financial LP | 115 | 115 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 354,166 | 354,166 | 0 | 0.36 | 0.83 | +0.47 | hold |
| T. Rowe Price Investment Management, Inc. | 35,400 | 35,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 610 | 610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 81 | 0 | -81 | 0.00 | 0.00 | -0.00 | sell |
| CNB Bank | 1,600 | 1,500 | -100 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 2,552 | 834 | -1,718 | 0.00 | 0.00 | -0.00 | sell |
| Annandale Capital, LLC | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,390 | 0 | -12,390 | 0.00 | 0.00 | -0.00 | sell |
| Key Client Fiduciary Advisors, LLC | 227,273 | 214,610 | -12,663 | 0.19 | 0.52 | +0.33 | sell |
| Virtu Financial LLC | 21,405 | 0 | -21,405 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 38,941 | 0 | -38,941 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 490,000 | 450,000 | -40,000 | 0.07 | 0.19 | +0.12 | sell |
| TD ASSET MANAGEMENT INC | 46,994 | 0 | -46,994 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 219,434 | 143,589 | -75,845 | 0.01 | 0.02 | +0.01 | sell |
| Rock Springs Capital Management LP | 1,074,517 | 832,937 | -241,580 | 0.04 | 0.09 | +0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 444,200 | 119,200 | -325,000 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 354,266 | 0 | -354,266 | 0.07 | 0.00 | -0.07 | sell |
| JANUS HENDERSON GROUP PLC | 358,060 | 0 | -358,060 | 0.00 | 0.00 | -0.00 | sell |