| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,648,795 | 7,796,895 | +4,148,100 | 0.76 | 2.22 | +1.46 | buy |
| Eversept Partners, LP | 62,575 | 154,130 | +91,555 | 0.07 | 0.27 | +0.20 | buy |
| BIT Capital GmbH | 18,000 | 91,391 | +73,391 | 0.02 | 0.09 | +0.07 | buy |
| PINNACLE ASSOCIATES LTD | 102,710 | 131,104 | +28,394 | 0.03 | 0.05 | +0.02 | buy |
| SummitTX Capital, L.P. | 347,760 | 374,270 | +26,510 | 0.23 | 0.32 | +0.09 | buy |
| Lighthouse Investment Partners, LLC | 10,559 | 20,785 | +10,226 | 0.01 | 0.02 | +0.01 | buy |
| OAK RIDGE INVESTMENTS LLC | 16,228 | 16,725 | +497 | 0.02 | 0.03 | +0.01 | buy |
| Crestwood Advisors Group, LLC | 100,086 | 100,274 | +188 | 0.04 | 0.05 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 17,148 | 15,675 | -1,473 | 0.03 | 0.03 | +0.00 | sell |
| Motley Fool Asset Management LLC | 78,141 | 70,651 | -7,490 | 0.07 | 0.09 | +0.02 | sell |
| DAFNA Capital Management LLC | 61,100 | 47,100 | -14,000 | 0.29 | 0.30 | +0.01 | sell |
| Headlands Technologies LLC | 50,800 | 25,305 | -25,495 | 0.12 | 0.09 | -0.03 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 157,132 | 128,035 | -29,097 | 0.07 | 0.06 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 60,308 | 25,456 | -34,852 | 0.04 | 0.02 | -0.02 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 3,214,533 | 3,158,368 | -56,165 | 0.26 | 0.39 | +0.13 | sell |
| Candriam S.C.A. | 1,096,182 | 1,001,841 | -94,341 | 0.12 | 0.15 | +0.03 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,426,834 | 1,241,556 | -185,278 | 0.12 | 0.18 | +0.06 | sell |
| Longaeva Partners L.P. | 228,107 | 41,347 | -186,760 | 0.18 | 0.03 | -0.15 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 809,333 | 588,494 | -220,839 | 2.69 | 2.56 | -0.13 | sell |
| Rock Springs Capital Management LP | 1,218,773 | 967,855 | -250,918 | 1.50 | 1.58 | +0.07 | sell |
| Bellevue Group AG | 2,380,000 | 1,982,775 | -397,225 | 1.19 | 1.39 | +0.21 | sell |
| Sofinnova Investments, Inc. | 3,145,888 | 1,717,505 | -1,428,383 | 2.50 | 2.96 | +0.46 | sell |