| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 350,000 | 830,000 | +480,000 | 0.23 | 0.45 | +0.22 | buy |
| BNP Paribas Asset Management Holding S.A. | 82,619 | 507,095 | +424,476 | 0.01 | 0.06 | +0.05 | buy |
| Candriam S.C.A. | 148,480 | 517,597 | +369,117 | 0.05 | 0.15 | +0.11 | buy |
| RTW INVESTMENTS, LP | 6,887,086 | 7,087,115 | +200,029 | 5.14 | 4.88 | -0.26 | buy |
| Avidity Partners Management LP | 844,500 | 933,500 | +89,000 | 1.54 | 1.55 | +0.00 | buy |
| Privium Fund Management B.V. | 166,506 | 215,102 | +48,596 | 2.23 | 2.68 | +0.45 | buy |
| EFG Asset Management (North America) Corp. | 68,468 | 116,836 | +48,368 | 0.62 | 0.94 | +0.32 | buy |
| First Light Asset Management, LLC | 744,665 | 790,446 | +45,781 | 2.86 | 2.83 | -0.04 | buy |
| BIT Capital GmbH | 1,555 | 41,000 | +39,445 | 0.01 | 0.14 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 201,044 | 238,544 | +37,500 | 1.55 | 1.56 | +0.02 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 120,985 | 152,500 | +31,515 | 0.02 | 0.02 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 359,166 | 389,291 | +30,125 | 0.21 | 0.18 | -0.03 | buy |
| NEOS Investment Management LLC | 10,797 | 31,860 | +21,063 | 0.05 | 0.09 | +0.04 | buy |
| Rock Springs Capital Management LP | 1,754,038 | 1,774,938 | +20,900 | 2.06 | 2.10 | +0.04 | buy |
| Clearbridge Investments, LLC | 2,383,492 | 2,400,854 | +17,362 | 0.10 | 0.09 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 35,378 | 49,537 | +14,159 | 0.10 | 0.12 | +0.03 | buy |
| Cinctive Capital Management LP | 98,051 | 111,751 | +13,700 | 0.33 | 0.27 | -0.06 | buy |
| China Universal Asset Management Co., Ltd. | 9,501 | 15,817 | +6,316 | 0.09 | 0.09 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 482,138 | 488,138 | +6,000 | 0.99 | 0.92 | -0.07 | buy |
| Blue Owl Capital Holdings LP | 263,238 | 268,238 | +5,000 | 3.01 | 2.50 | -0.51 | buy |
| PDT Partners, LLC | 47,501 | 52,474 | +4,973 | 0.25 | 0.23 | -0.02 | buy |
| WOODSTOCK CORP | 8,060 | 11,124 | +3,064 | 0.04 | 0.05 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 7,105 | 8,299 | +1,194 | 0.22 | 0.21 | -0.01 | buy |
| DUALITY ADVISERS, LP | 39,371 | 39,977 | +606 | 0.20 | 0.18 | -0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 119,300 | 119,339 | +39 | 0.17 | 0.16 | -0.01 | buy |
| PINNACLE ASSOCIATES LTD | 119,360 | 119,387 | +27 | 0.10 | 0.09 | -0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 5,146 | 5,161 | +15 | 0.04 | 0.04 | -0.00 | buy |
| NFJ INVESTMENT GROUP, LLC | 44,084 | 43,962 | -122 | 0.06 | 0.06 | -0.00 | sell |
| Motley Fool Wealth Management, LLC | 164,235 | 164,076 | -159 | 0.41 | 0.40 | -0.02 | sell |
| GILDER GAGNON HOWE & CO LLC | 17,600 | 17,423 | -177 | 0.01 | 0.01 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 45,465 | 45,043 | -422 | 0.00 | 0.00 | -0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 27,773 | 26,225 | -1,548 | 0.01 | 0.01 | -0.00 | sell |
| Motley Fool Asset Management LLC | 149,443 | 146,526 | -2,917 | 0.53 | 0.44 | -0.09 | sell |
| E Fund Management Co., Ltd. | 11,871 | 8,577 | -3,294 | 0.04 | 0.02 | -0.01 | sell |
| GW&K Investment Management, LLC | 307,529 | 303,377 | -4,152 | 0.14 | 0.12 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 15,690 | 4,900 | -10,790 | 0.19 | 0.06 | -0.13 | sell |
| FRED ALGER MANAGEMENT, LLC | 603,976 | 581,551 | -22,425 | 0.16 | 0.13 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 718,978 | 687,619 | -31,359 | 0.17 | 0.14 | -0.03 | sell |
| Hudson Bay Capital Management LP | 490,000 | 305,100 | -184,900 | 0.15 | 0.08 | -0.07 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 4,118,008 | 3,859,447 | -258,561 | 0.60 | 0.50 | -0.09 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,126,306 | 1,676,811 | -449,495 | 4.60 | 2.91 | -1.69 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,025,000 | 150,000 | -875,000 | 0.10 | 0.01 | -0.09 | sell |