| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 28,552 | 707,905 | +679,353 | 0.00 | 0.03 | +0.03 | buy |
| Avoro Capital Advisors LLC | 350,000 | 830,000 | +480,000 | 0.23 | 0.45 | +0.22 | buy |
| BNP Paribas Asset Management Holding S.A. | 82,619 | 507,095 | +424,476 | 0.01 | 0.06 | +0.05 | buy |
| Candriam S.C.A. | 148,480 | 517,597 | +369,117 | 0.05 | 0.15 | +0.11 | buy |
| Eagle Health Investments LP | 0 | 299,700 | +299,700 | 0.00 | 2.67 | +2.67 | buy |
| TWO SIGMA INVESTMENTS, LP | 126,610 | 415,314 | +288,704 | 0.01 | 0.05 | +0.03 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 266,967 | +266,967 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 188,900 | 448,200 | +259,300 | 0.02 | 0.05 | +0.03 | buy |
| MPM BioImpact LLC | 0 | 245,590 | +245,590 | 0.00 | 1.84 | +1.84 | buy |
| GOLDMAN SACHS GROUP INC | 155,052 | 364,122 | +209,070 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 6,887,086 | 7,087,115 | +200,029 | 5.14 | 4.88 | -0.26 | buy |
| Artal Group S.A. | 0 | 177,932 | +177,932 | 0.00 | 0.21 | +0.21 | buy |
| Deep Track Capital, LP | 0 | 167,784 | +167,784 | 0.00 | 0.23 | +0.23 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 157,276 | +157,276 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 108,355 | 230,767 | +122,412 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,448,698 | 3,568,873 | +120,175 | 0.02 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 151,727 | 266,641 | +114,914 | 0.10 | 0.14 | +0.03 | buy |
| UBS Group AG | 57,821 | 169,163 | +111,342 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 110,000 | +110,000 | 0.00 | 0.42 | +0.42 | buy |
| Verition Fund Management LLC | 7,070 | 115,925 | +108,855 | 0.00 | 0.05 | +0.05 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 99,000 | +99,000 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 342,812 | 440,798 | +97,986 | 0.13 | 0.16 | +0.03 | buy |
| CITADEL ADVISORS LLC | 200,054 | 293,305 | +93,251 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 844,500 | 933,500 | +89,000 | 1.54 | 1.55 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 343,412 | 430,536 | +87,124 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 170,689 | 251,197 | +80,508 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 430,018 | 502,852 | +72,834 | 0.00 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 8,952 | 79,869 | +70,917 | 0.01 | 0.10 | +0.09 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 86,457 | 155,525 | +69,068 | 0.02 | 0.03 | +0.01 | buy |
| Laurion Capital Management LP | 0 | 68,000 | +68,000 | 0.00 | 0.09 | +0.09 | buy |
| Man Group plc | 87,811 | 153,641 | +65,830 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,283,622 | 1,339,826 | +56,204 | 0.01 | 0.01 | -0.00 | buy |
| Privium Fund Management B.V. | 166,506 | 215,102 | +48,596 | 2.23 | 2.68 | +0.45 | buy |
| EFG Asset Management (North America) Corp. | 68,468 | 116,836 | +48,368 | 0.62 | 0.94 | +0.32 | buy |
| CITIGROUP INC | 110,510 | 156,849 | +46,339 | 0.01 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 744,665 | 790,446 | +45,781 | 2.86 | 2.83 | -0.04 | buy |
| Squarepoint Ops LLC | 15,841 | 57,125 | +41,284 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 1,555 | 41,000 | +39,445 | 0.01 | 0.17 | +0.16 | buy |
| ExodusPoint Capital Management, LP | 0 | 38,025 | +38,025 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 201,044 | 238,544 | +37,500 | 1.78 | 1.80 | +0.02 | buy |
| Neuberger Berman Group LLC | 69,746 | 104,939 | +35,193 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,172,866 | 1,207,225 | +34,359 | 0.03 | 0.03 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 120,985 | 152,500 | +31,515 | 0.02 | 0.02 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 30,753 | +30,753 | 0.00 | 0.14 | +0.14 | buy |
| Graham Capital Management, L.P. | 13,860 | 44,035 | +30,175 | 0.02 | 0.06 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 359,166 | 389,291 | +30,125 | 0.21 | 0.18 | -0.03 | buy |
| NORGES BANK | 770,506 | 798,504 | +27,998 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 27,004 | +27,004 | 0.00 | 0.06 | +0.06 | buy |
| VANGUARD GROUP INC | 8,673,432 | 8,700,007 | +26,575 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 23,005 | +23,005 | 0.00 | 0.05 | +0.05 | buy |
| Cubist Systematic Strategies, LLC | 0 | 22,631 | +22,631 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 10,797 | 31,860 | +21,063 | 0.05 | 0.09 | +0.04 | buy |
| Rock Springs Capital Management LP | 1,754,038 | 1,774,938 | +20,900 | 2.07 | 2.11 | +0.04 | buy |
| Aquatic Capital Management LLC | 0 | 20,200 | +20,200 | 0.00 | 0.03 | +0.03 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.61 | +0.61 | buy |
| Exome Asset Management LLC | 0 | 17,800 | +17,800 | 0.00 | 0.71 | +0.71 | buy |
| Clearbridge Investments, LLC | 2,383,492 | 2,400,854 | +17,362 | 0.10 | 0.09 | -0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 4,900 | 21,388 | +16,488 | 0.02 | 0.07 | +0.05 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 15,712 | +15,712 | 0.00 | 0.08 | +0.08 | buy |
| Bayesian Capital Management, LP | 0 | 15,302 | +15,302 | 0.00 | 0.07 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 272,339 | 287,504 | +15,165 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 14,792 | +14,792 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 14,600 | +14,600 | 0.00 | 0.16 | +0.16 | buy |
| Hennion & Walsh Asset Management, Inc. | 35,378 | 49,537 | +14,159 | 0.10 | 0.12 | +0.03 | buy |
| Cinctive Capital Management LP | 98,051 | 111,751 | +13,700 | 0.33 | 0.27 | -0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,541 | 48,950 | +13,409 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,023,136 | 1,036,374 | +13,238 | 0.05 | 0.05 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 471,825 | 484,381 | +12,556 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 118,206 | 130,260 | +12,054 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 11,522 | +11,522 | 0.00 | 0.09 | +0.09 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,124 | +11,124 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 72,832 | 83,869 | +11,037 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,549 | +10,549 | 0.00 | 0.04 | +0.04 | buy |
| DnB Asset Management AS | 0 | 10,021 | +10,021 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 10,000 | +10,000 | 0.00 | 0.03 | +0.03 | buy |
| Trexquant Investment LP | 53,500 | 63,163 | +9,663 | 0.06 | 0.06 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 9,077 | +9,077 | 0.00 | 0.04 | +0.04 | buy |
| WINTON GROUP Ltd | 0 | 8,755 | +8,755 | 0.00 | 0.03 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 27,709 | 35,895 | +8,186 | 0.01 | 0.01 | +0.00 | buy |
| Savant Capital, LLC | 0 | 7,245 | +7,245 | 0.00 | 0.00 | +0.00 | buy |
| BOKF, NA | 0 | 6,736 | +6,736 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 9,501 | 15,817 | +6,316 | 0.09 | 0.09 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 482,138 | 488,138 | +6,000 | 0.99 | 0.92 | -0.07 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 101,672 | 107,572 | +5,900 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 7,406 | 13,221 | +5,815 | 0.08 | 0.08 | +0.01 | buy |
| Teza Capital Management LLC | 0 | 5,293 | +5,293 | 0.00 | 0.03 | +0.03 | buy |
| Pathstone Holdings, LLC | 0 | 5,168 | +5,168 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 250,052 | 255,078 | +5,026 | 0.02 | 0.01 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 263,238 | 268,238 | +5,000 | 3.01 | 2.50 | -0.51 | buy |
| PDT Partners, LLC | 47,501 | 52,474 | +4,973 | 0.25 | 0.23 | -0.02 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 4,863 | +4,863 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 141,552 | 145,852 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| INCEPTIONR LLC | 0 | 4,289 | +4,289 | 0.00 | 0.05 | +0.05 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 3,587 | +3,587 | 0.00 | 0.04 | +0.04 | buy |
| WOODSTOCK CORP | 8,060 | 11,124 | +3,064 | 0.04 | 0.05 | +0.01 | buy |
| GROUP ONE TRADING LLC | 6,284 | 9,135 | +2,851 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 11,076 | 13,668 | +2,592 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,727 | 4,160 | +2,433 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 85,569 | 87,673 | +2,104 | 0.01 | 0.01 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 1,550 | +1,550 | 0.00 | 0.00 | +0.00 | buy |