| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,673,432 | 8,700,007 | +26,575 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 6,887,086 | 7,087,115 | +200,029 | 5.14 | 4.88 | -0.26 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,415,029 | 4,097,975 | -317,054 | 0.04 | 0.03 | -0.01 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 4,118,008 | 3,859,447 | -258,561 | 0.60 | 0.50 | -0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,448,698 | 3,568,873 | +120,175 | 0.02 | 0.02 | -0.00 | buy |
| STATE STREET CORP | 3,252,502 | 2,851,250 | -401,252 | 0.01 | 0.01 | -0.00 | sell |
| Clearbridge Investments, LLC | 2,383,492 | 2,400,854 | +17,362 | 0.10 | 0.09 | -0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 2,241,832 | 2,241,832 | 0 | 0.70 | 0.58 | -0.13 | hold |
| FEDERATED HERMES, INC. | 2,446,500 | 1,938,680 | -507,820 | 0.29 | 0.21 | -0.08 | sell |
| Rock Springs Capital Management LP | 1,754,038 | 1,774,938 | +20,900 | 2.07 | 2.11 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,126,306 | 1,676,811 | -449,495 | 4.65 | 3.30 | -1.35 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,578,603 | 1,482,471 | -96,132 | 0.03 | 0.02 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,466,547 | 1,466,547 | 0 | 0.80 | 0.86 | +0.06 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,283,622 | 1,339,826 | +56,204 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 1,172,866 | 1,207,225 | +34,359 | 0.03 | 0.03 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,023,136 | 1,036,374 | +13,238 | 0.05 | 0.05 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,489,486 | 968,990 | -520,496 | 0.14 | 0.07 | -0.06 | sell |
| Avidity Partners Management LP | 844,500 | 933,500 | +89,000 | 1.54 | 1.55 | +0.00 | buy |
| Bank of New York Mellon Corp | 1,010,830 | 911,656 | -99,174 | 0.01 | 0.01 | -0.00 | sell |
| Avoro Capital Advisors LLC | 350,000 | 830,000 | +480,000 | 0.23 | 0.45 | +0.22 | buy |
| NORGES BANK | 770,506 | 798,504 | +27,998 | 0.01 | 0.01 | -0.00 | buy |
| First Light Asset Management, LLC | 744,665 | 790,446 | +45,781 | 2.86 | 2.83 | -0.04 | buy |
| FMR LLC | 992,951 | 782,032 | -210,919 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 28,552 | 707,905 | +679,353 | 0.00 | 0.03 | +0.03 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 718,978 | 687,619 | -31,359 | 0.17 | 0.14 | -0.03 | sell |
| FRED ALGER MANAGEMENT, LLC | 603,976 | 581,551 | -22,425 | 0.16 | 0.13 | -0.02 | sell |
| Candriam S.C.A. | 148,480 | 517,597 | +369,117 | 0.05 | 0.15 | +0.11 | buy |
| BNP Paribas Asset Management Holding S.A. | 82,619 | 507,095 | +424,476 | 0.01 | 0.06 | +0.05 | buy |
| MORGAN STANLEY | 597,549 | 504,382 | -93,167 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 430,018 | 502,852 | +72,834 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 482,138 | 488,138 | +6,000 | 0.99 | 0.92 | -0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 471,825 | 484,381 | +12,556 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 188,900 | 448,200 | +259,300 | 0.02 | 0.05 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 342,812 | 440,798 | +97,986 | 0.13 | 0.16 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 343,412 | 430,536 | +87,124 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 126,610 | 415,314 | +288,704 | 0.01 | 0.05 | +0.03 | buy |
| Woodline Partners LP | 400,124 | 400,124 | 0 | 0.21 | 0.17 | -0.04 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 359,166 | 389,291 | +30,125 | 0.21 | 0.18 | -0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 385,340 | 385,340 | 0 | 0.98 | 0.94 | -0.04 | hold |
| FIRST TRUST ADVISORS LP | 1,163,077 | 368,219 | -794,858 | 0.06 | 0.02 | -0.04 | sell |
| NORTHERN TRUST CORP | 374,661 | 367,623 | -7,038 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 155,052 | 364,122 | +209,070 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 359,000 | 359,000 | 0 | 0.28 | 0.26 | -0.02 | hold |
| AXA S.A. | 332,712 | 332,767 | +55 | 0.05 | 0.05 | -0.00 | buy |
| Hudson Bay Capital Management LP | 490,000 | 305,100 | -184,900 | 0.21 | 0.12 | -0.08 | sell |
| GW&K Investment Management, LLC | 307,529 | 303,377 | -4,152 | 0.14 | 0.12 | -0.01 | sell |
| Eagle Health Investments LP | 0 | 299,700 | +299,700 | 0.00 | 2.67 | +2.67 | buy |
| CITADEL ADVISORS LLC | 200,054 | 293,305 | +93,251 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 272,339 | 287,504 | +15,165 | 0.01 | 0.01 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 263,238 | 268,238 | +5,000 | 3.01 | 2.50 | -0.51 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 266,967 | +266,967 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 151,727 | 266,641 | +114,914 | 0.10 | 0.14 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 250,052 | 255,078 | +5,026 | 0.02 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 277,942 | 252,160 | -25,782 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 170,689 | 251,197 | +80,508 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 245,590 | +245,590 | 0.00 | 1.84 | +1.84 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 201,044 | 238,544 | +37,500 | 1.78 | 1.80 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 108,355 | 230,767 | +122,412 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 221,360 | 220,360 | -1,000 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 224,236 | 220,317 | -3,919 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 214,738 | 215,916 | +1,178 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 166,506 | 215,102 | +48,596 | 2.23 | 2.68 | +0.45 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 185,000 | 185,000 | 0 | 0.21 | 0.18 | -0.04 | hold |
| Rafferty Asset Management, LLC | 221,910 | 181,484 | -40,426 | 0.04 | 0.03 | -0.01 | sell |
| Artal Group S.A. | 0 | 177,932 | +177,932 | 0.00 | 0.21 | +0.21 | buy |
| UBS Group AG | 57,821 | 169,163 | +111,342 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 167,784 | +167,784 | 0.00 | 0.23 | +0.23 | buy |
| Motley Fool Wealth Management, LLC | 164,235 | 164,076 | -159 | 0.41 | 0.40 | -0.02 | sell |
| Russell Investments Group, Ltd. | 200,615 | 163,141 | -37,474 | 0.02 | 0.01 | -0.01 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 157,276 | +157,276 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 110,510 | 156,849 | +46,339 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 86,457 | 155,525 | +69,068 | 0.02 | 0.03 | +0.01 | buy |
| Man Group plc | 87,811 | 153,641 | +65,830 | 0.01 | 0.02 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 120,985 | 152,500 | +31,515 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,025,000 | 150,000 | -875,000 | 0.10 | 0.01 | -0.09 | sell |
| Motley Fool Asset Management LLC | 149,443 | 146,526 | -2,917 | 0.53 | 0.44 | -0.09 | sell |
| Swiss National Bank | 141,552 | 145,852 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 142,541 | 142,174 | -367 | 0.02 | 0.02 | -0.00 | sell |
| Aberdeen Group plc | 141,117 | 141,117 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 118,206 | 130,260 | +12,054 | 0.00 | 0.00 | -0.00 | buy |
| PINNACLE ASSOCIATES LTD | 119,360 | 119,387 | +27 | 0.10 | 0.09 | -0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 119,300 | 119,339 | +39 | 0.17 | 0.16 | -0.01 | buy |
| BARCLAYS PLC | 166,742 | 118,773 | -47,969 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 68,468 | 116,836 | +48,368 | 0.62 | 0.94 | +0.32 | buy |
| Verition Fund Management LLC | 7,070 | 115,925 | +108,855 | 0.00 | 0.05 | +0.05 | buy |
| Cinctive Capital Management LP | 98,051 | 111,751 | +13,700 | 0.33 | 0.27 | -0.06 | buy |
| Vestal Point Capital, LP | 0 | 110,000 | +110,000 | 0.00 | 0.42 | +0.42 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 101,672 | 107,572 | +5,900 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 69,746 | 104,939 | +35,193 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 168,684 | 102,466 | -66,218 | 0.01 | 0.00 | -0.00 | sell |
| Crestwood Advisors Group, LLC | 100,258 | 100,258 | 0 | 0.11 | 0.10 | -0.01 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 99,000 | +99,000 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 100,665 | 91,663 | -9,002 | 0.01 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 85,569 | 87,673 | +2,104 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 72,832 | 83,869 | +11,037 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 8,952 | 79,869 | +70,917 | 0.01 | 0.10 | +0.09 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 77,075 | 74,413 | -2,662 | 0.01 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 0 | 68,000 | +68,000 | 0.00 | 0.09 | +0.09 | buy |
| SEI INVESTMENTS CO | 65,380 | 65,996 | +616 | 0.01 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 120,715 | 65,438 | -55,277 | 0.01 | 0.00 | -0.00 | sell |