| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,183,081 | 2,149,000 | +965,919 | 0.09 | 0.14 | +0.06 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,151,314 | 2,024,500 | +873,186 | 1.65 | 2.72 | +1.07 | buy |
| Deep Track Capital, LP | 653,513 | 1,350,000 | +696,487 | 1.03 | 1.58 | +0.55 | buy |
| Parkman Healthcare Partners LLC | 100,159 | 304,244 | +204,085 | 0.56 | 1.31 | +0.75 | buy |
| BNP Paribas Asset Management Holding S.A. | 958,077 | 1,150,456 | +192,379 | 0.10 | 0.11 | +0.01 | buy |
| Aberdeen Group plc | 317,125 | 478,904 | +161,779 | 0.03 | 0.03 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 135,609 | 202,213 | +66,604 | 0.01 | 0.02 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 33,857 | 95,404 | +61,547 | 0.02 | 0.06 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 466,265 | 524,637 | +58,372 | 0.09 | 0.11 | +0.01 | buy |
| Granite Investment Partners, LLC | 160,415 | 216,883 | +56,468 | 0.29 | 0.40 | +0.11 | buy |
| PDT Partners, LLC | 48,859 | 104,921 | +56,062 | 0.18 | 0.27 | +0.09 | buy |
| Alyeska Investment Group, L.P. | 1,439,740 | 1,495,351 | +55,611 | 0.23 | 0.22 | -0.01 | buy |
| Candriam S.C.A. | 674,257 | 728,017 | +53,760 | 0.16 | 0.17 | +0.00 | buy |
| B Group, Inc. | 7,596 | 47,500 | +39,904 | 0.20 | 1.49 | +1.30 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 228,776 | 267,385 | +38,609 | 1.74 | 2.23 | +0.49 | buy |
| Ikarian Capital, LLC | 178,989 | 216,989 | +38,000 | 2.15 | 2.56 | +0.41 | buy |
| Motley Fool Asset Management LLC | 48,448 | 84,473 | +36,025 | 0.11 | 0.17 | +0.07 | buy |
| Blue Owl Capital Holdings LP | 118,238 | 153,238 | +35,000 | 1.15 | 1.79 | +0.64 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 829,465 | 852,657 | +23,192 | 0.29 | 0.30 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 324,437 | 340,975 | +16,538 | 0.83 | 0.88 | +0.05 | buy |
| F/m Investments LLC | 42,004 | 58,314 | +16,310 | 0.07 | 0.08 | +0.02 | buy |
| B. Metzler seel. Sohn & Co. AG | 15,457 | 30,038 | +14,581 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 62,960 | 77,261 | +14,301 | 0.14 | 0.22 | +0.08 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 14,090 | 22,370 | +8,280 | 0.12 | 0.16 | +0.04 | buy |
| MPM BioImpact LLC | 391,018 | 398,445 | +7,427 | 2.34 | 2.48 | +0.14 | buy |
| Bayforest Capital Ltd | 3,144 | 9,190 | +6,046 | 0.17 | 0.14 | -0.02 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 163,888 | 169,467 | +5,579 | 0.20 | 0.20 | -0.00 | buy |
| Bayesian Capital Management, LP | 8,268 | 13,783 | +5,515 | 0.04 | 0.08 | +0.04 | buy |
| Point72 Hong Kong Ltd | 27,399 | 32,740 | +5,341 | 0.07 | 0.08 | +0.01 | buy |
| INCEPTIONR LLC | 8,227 | 12,803 | +4,576 | 0.08 | 0.14 | +0.06 | buy |
| Magnetar Financial LLC | 6,779 | 11,147 | +4,368 | 0.01 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 6,939 | 10,982 | +4,043 | 0.12 | 0.18 | +0.06 | buy |
| DnB Asset Management AS | 12,132 | 14,268 | +2,136 | 0.00 | 0.00 | +0.00 | buy |
| denkapparat Operations GmbH | 4,912 | 6,892 | +1,980 | 0.31 | 0.26 | -0.04 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 500,717 | 502,023 | +1,306 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 7,200 | 8,300 | +1,100 | 0.02 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,939 | 2,364 | +425 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 17,362 | 17,757 | +395 | 0.06 | 0.05 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 21,000 | 21,290 | +290 | 0.89 | 0.89 | +0.01 | buy |
| Simplify Asset Management Inc. | 16,810 | 16,900 | +90 | 0.05 | 0.03 | -0.02 | buy |
| Teza Capital Management LLC | 5,857 | 5,941 | +84 | 0.04 | 0.10 | +0.06 | buy |
| Signature Resources Capital Management, LLC | 15 | 14 | -1 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 16,928 | 16,888 | -40 | 0.01 | 0.01 | +0.00 | sell |
| Washington Trust Advisors, Inc. | 57 | 8 | -49 | 0.00 | 0.00 | -0.00 | sell |
| STEPH & CO | 2,617 | 2,386 | -231 | 0.04 | 0.03 | -0.01 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,686,716 | 1,685,729 | -987 | 0.14 | 0.13 | -0.02 | sell |
| Crestwood Advisors Group, LLC | 101,730 | 100,730 | -1,000 | 0.08 | 0.07 | -0.01 | sell |
| PROFUND ADVISORS LLC | 18,591 | 17,580 | -1,011 | 0.03 | 0.03 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 19,580 | 18,554 | -1,026 | 0.08 | 0.06 | -0.01 | sell |
| Woodline Partners LP | 269,556 | 268,462 | -1,094 | 0.08 | 0.06 | -0.01 | sell |
| PITCAIRN CO | 8,342 | 6,700 | -1,642 | 0.02 | 0.01 | -0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 39,673 | 37,667 | -2,006 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 63,220 | 61,160 | -2,060 | 0.12 | 0.10 | -0.02 | sell |
| EMERALD ADVISERS, LLC | 518,328 | 516,228 | -2,100 | 0.84 | 0.84 | -0.00 | sell |
| Motley Fool Wealth Management, LLC | 153,835 | 149,596 | -4,239 | 0.33 | 0.32 | -0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 245,000 | 240,000 | -5,000 | 0.12 | 0.18 | +0.06 | sell |
| PINNACLE ASSOCIATES LTD | 148,493 | 143,375 | -5,118 | 0.08 | 0.08 | -0.01 | sell |
| BIT Capital GmbH | 29,870 | 21,655 | -8,215 | 0.10 | 0.07 | -0.03 | sell |
| Privium Fund Management B.V. | 258,380 | 249,804 | -8,576 | 2.46 | 2.36 | -0.10 | sell |
| AXQ CAPITAL, LP | 23,077 | 12,346 | -10,731 | 0.44 | 0.18 | -0.26 | sell |
| EFG Asset Management (North America) Corp. | 139,443 | 122,942 | -16,501 | 0.80 | 0.74 | -0.06 | sell |
| Cutter Capital Management, LP | 406,803 | 379,303 | -27,500 | 7.01 | 5.98 | -1.03 | sell |
| Avidity Partners Management LP | 352,000 | 322,100 | -29,900 | 1.48 | 2.41 | +0.93 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 346,597 | 311,101 | -35,496 | 0.01 | 0.01 | -0.00 | sell |
| Fisher Asset Management, LLC | 265,189 | 207,755 | -57,434 | 0.00 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 2,322,205 | 2,259,705 | -62,500 | 0.08 | 0.07 | -0.01 | sell |
| First Light Asset Management, LLC | 763,607 | 632,033 | -131,574 | 3.07 | 2.61 | -0.46 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 4,298,003 | 4,163,561 | -134,442 | 0.54 | 0.51 | -0.02 | sell |
| GREAT LAKES ADVISORS, LLC | 191,129 | 13,311 | -177,818 | 0.07 | 0.00 | -0.06 | sell |
| RTW INVESTMENTS, LP | 1,968,002 | 1,707,402 | -260,600 | 1.25 | 0.95 | -0.31 | sell |
| Rock Springs Capital Management LP | 1,739,813 | 1,394,434 | -345,379 | 2.79 | 2.89 | +0.10 | sell |
| Vestal Point Capital, LP | 1,500,000 | 500,000 | -1,000,000 | 3.74 | 1.29 | -2.45 | sell |