| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,183,081 | 2,149,000 | +965,919 | 0.09 | 0.14 | +0.06 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,151,314 | 2,024,500 | +873,186 | 1.79 | 2.97 | +1.17 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,512,423 | 3,218,942 | +706,519 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 653,513 | 1,350,000 | +696,487 | 1.03 | 1.58 | +0.55 | buy |
| Polar Capital Holdings Plc | 0 | 651,383 | +651,383 | 0.00 | 0.14 | +0.14 | buy |
| LOOMIS SAYLES & CO L P | 0 | 561,479 | +561,479 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 286,079 | 556,417 | +270,338 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,173,638 | 1,409,199 | +235,561 | 0.05 | 0.06 | +0.00 | buy |
| SG Americas Securities, LLC | 9,665 | 237,573 | +227,908 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 100,159 | 304,244 | +204,085 | 0.56 | 1.31 | +0.75 | buy |
| BNP Paribas Asset Management Holding S.A. | 958,077 | 1,150,456 | +192,379 | 0.10 | 0.11 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 427,359 | 600,446 | +173,087 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 317,125 | 478,904 | +161,779 | 0.03 | 0.03 | +0.01 | buy |
| Legal & General Group Plc | 98,732 | 258,967 | +160,235 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 297,394 | 455,148 | +157,754 | 0.04 | 0.05 | +0.01 | buy |
| Assenagon Asset Management S.A. | 69,273 | 215,890 | +146,617 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 325,651 | 469,482 | +143,831 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 388,502 | 527,980 | +139,478 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 87,989 | 219,884 | +131,895 | 0.01 | 0.02 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 121,510 | +121,510 | 0.00 | 0.06 | +0.06 | buy |
| Trexquant Investment LP | 156,656 | 268,666 | +112,010 | 0.08 | 0.11 | +0.04 | buy |
| JPMORGAN CHASE & CO | 205,787 | 309,471 | +103,684 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 81,515 | 165,647 | +84,132 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,562,790 | 1,646,537 | +83,747 | 0.01 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 82,000 | +82,000 | 0.00 | 0.34 | +0.34 | buy |
| Schonfeld Strategic Advisors LLC | 747,429 | 824,418 | +76,989 | 0.20 | 0.20 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 216,587 | 293,374 | +76,787 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 135,609 | 202,213 | +66,604 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 22,284 | 87,811 | +65,527 | 0.02 | 0.08 | +0.05 | buy |
| TWINBEECH CAPITAL LP | 33,857 | 95,404 | +61,547 | 0.02 | 0.06 | +0.04 | buy |
| Caption Management, LLC | 117,571 | 178,828 | +61,257 | 0.20 | 0.30 | +0.09 | buy |
| FRED ALGER MANAGEMENT, LLC | 466,265 | 524,637 | +58,372 | 0.09 | 0.11 | +0.01 | buy |
| Granite Investment Partners, LLC | 160,415 | 216,883 | +56,468 | 0.29 | 0.40 | +0.11 | buy |
| PDT Partners, LLC | 48,859 | 104,921 | +56,062 | 0.18 | 0.27 | +0.09 | buy |
| Alyeska Investment Group, L.P. | 1,439,740 | 1,495,351 | +55,611 | 0.23 | 0.22 | -0.01 | buy |
| Candriam S.C.A. | 674,257 | 728,017 | +53,760 | 0.16 | 0.17 | +0.00 | buy |
| Knott David M Jr | 0 | 48,000 | +48,000 | 0.00 | 0.82 | +0.82 | buy |
| ALGERT GLOBAL LLC | 82,793 | 130,320 | +47,527 | 0.08 | 0.12 | +0.03 | buy |
| CITIGROUP INC | 66,921 | 113,128 | +46,207 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 93,484 | 138,484 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 254,700 | 299,600 | +44,900 | 0.02 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 43,274 | +43,274 | 0.00 | 0.14 | +0.14 | buy |
| B Group, Inc. | 7,596 | 47,500 | +39,904 | 0.20 | 1.49 | +1.30 | buy |
| NORTHERN TRUST CORP | 528,965 | 568,389 | +39,424 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 228,776 | 267,385 | +38,609 | 1.78 | 2.39 | +0.61 | buy |
| Ikarian Capital, LLC | 178,989 | 216,989 | +38,000 | 2.15 | 2.56 | +0.41 | buy |
| Motley Fool Asset Management LLC | 48,448 | 84,473 | +36,025 | 0.11 | 0.17 | +0.07 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 0 | 35,695 | +35,695 | 0.00 | 0.03 | +0.03 | buy |
| Blue Owl Capital Holdings LP | 118,238 | 153,238 | +35,000 | 1.15 | 1.79 | +0.64 | buy |
| Russell Investments Group, Ltd. | 69,187 | 103,822 | +34,635 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 142,628 | 176,851 | +34,223 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 14 | 34,043 | +34,029 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 32,535 | +32,535 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,376 | 232,360 | +29,984 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 598,189 | 626,400 | +28,211 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 35,254 | 63,415 | +28,161 | 0.03 | 0.04 | +0.01 | buy |
| Walleye Capital LLC | 11,197 | 37,087 | +25,890 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 913,500 | 937,200 | +23,700 | 0.09 | 0.08 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 829,465 | 852,657 | +23,192 | 0.29 | 0.30 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,474 | +22,474 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 961,794 | 983,638 | +21,844 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 11,248 | 31,780 | +20,532 | 0.04 | 0.06 | +0.02 | buy |
| Graham Capital Management, L.P. | 59,129 | 79,476 | +20,347 | 0.08 | 0.09 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 614,948 | 633,152 | +18,204 | 0.06 | 0.05 | -0.01 | buy |
| SIMPLEX TRADING, LLC | 5,929 | 23,991 | +18,062 | 0.01 | 0.03 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 27,016 | 44,901 | +17,885 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 324,437 | 340,975 | +16,538 | 0.83 | 0.88 | +0.05 | buy |
| F/m Investments LLC | 42,004 | 58,314 | +16,310 | 0.07 | 0.08 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 697,236 | 712,393 | +15,157 | 0.03 | 0.03 | -0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 15,457 | 30,038 | +14,581 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 62,960 | 77,261 | +14,301 | 0.14 | 0.22 | +0.08 | buy |
| SEI INVESTMENTS CO | 98,309 | 112,214 | +13,905 | 0.01 | 0.01 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 34,225 | 48,084 | +13,859 | 0.01 | 0.02 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 13,328 | +13,328 | 0.00 | 0.19 | +0.19 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,839 | +12,839 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 54,455 | 65,655 | +11,200 | 0.07 | 0.08 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 131,344 | 140,446 | +9,102 | 0.00 | 0.00 | -0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 8,421 | +8,421 | 0.00 | 0.14 | +0.14 | buy |
| DEUTSCHE BANK AG\ | 1,693,108 | 1,701,493 | +8,385 | 0.03 | 0.02 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 14,090 | 22,370 | +8,280 | 0.12 | 0.16 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,655 | +7,655 | 0.00 | 0.08 | +0.08 | buy |
| Entropy Technologies, LP | 0 | 7,549 | +7,549 | 0.00 | 0.03 | +0.03 | buy |
| MPM BioImpact LLC | 391,018 | 398,445 | +7,427 | 2.34 | 2.48 | +0.14 | buy |
| FIDUCIARY TRUST CO | 0 | 6,922 | +6,922 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 6,900 | +6,900 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 29,221 | 36,071 | +6,850 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,345 | 74,401 | +6,056 | 0.01 | 0.01 | -0.00 | buy |
| COMERICA BANK | 1,303 | 7,352 | +6,049 | 0.00 | 0.00 | +0.00 | buy |
| Bayforest Capital Ltd | 3,144 | 9,190 | +6,046 | 0.17 | 0.14 | -0.02 | buy |
| HRT FINANCIAL LP | 28,500 | 34,435 | +5,935 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 13,396 | 19,297 | +5,901 | 0.00 | 0.00 | +0.00 | buy |
| SIH Partners, LLLP | 0 | 5,738 | +5,738 | 0.00 | 0.02 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 14,300 | 19,969 | +5,669 | 0.01 | 0.01 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 163,888 | 169,467 | +5,579 | 0.20 | 0.20 | -0.00 | buy |
| Bayesian Capital Management, LP | 8,268 | 13,783 | +5,515 | 0.04 | 0.08 | +0.04 | buy |
| FEDERATED HERMES, INC. | 2,049,800 | 2,055,200 | +5,400 | 0.19 | 0.16 | -0.03 | buy |
| Point72 Hong Kong Ltd | 27,399 | 32,740 | +5,341 | 0.07 | 0.08 | +0.01 | buy |
| INCEPTIONR LLC | 8,227 | 12,803 | +4,576 | 0.08 | 0.14 | +0.06 | buy |
| Magnetar Financial LLC | 6,779 | 11,147 | +4,368 | 0.01 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 6,939 | 10,982 | +4,043 | 0.12 | 0.18 | +0.06 | buy |