| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,631,554 | 7,299,598 | +668,044 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,303,046 | 5,021,441 | +718,395 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,360,497 | 4,578,024 | +3,217,527 | 0.02 | 0.04 | +0.03 | buy |
| RTW INVESTMENTS, LP | 3,000,139 | 3,648,795 | +648,656 | 0.69 | 0.76 | +0.07 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,485,724 | 3,214,533 | -271,191 | 0.24 | 0.26 | +0.02 | sell |
| Sofinnova Investments, Inc. | 83,300 | 3,145,888 | +3,062,588 | 0.08 | 3.30 | +3.22 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,910 | 2,640,812 | +178,902 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 2,580 | 2,380,000 | +2,377,420 | 0.00 | 1.19 | +1.19 | buy |
| Assenagon Asset Management S.A. | 199,720 | 2,257,671 | +2,057,951 | 0.01 | 0.08 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 424,049 | 2,205,820 | +1,781,771 | 0.01 | 0.04 | +0.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,965,084 | 2,191,182 | +226,098 | 0.48 | 0.47 | -0.01 | buy |
| CITADEL ADVISORS LLC | 2,326,125 | 2,115,491 | -210,634 | 0.04 | 0.03 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,838,208 | 1,849,391 | +11,183 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 880,644 | 1,772,184 | +891,540 | 0.01 | 0.03 | +0.01 | buy |
| GW&K Investment Management, LLC | 1,375,407 | 1,615,426 | +240,019 | 0.27 | 0.30 | +0.02 | buy |
| MORGAN STANLEY | 1,826,295 | 1,500,528 | -325,767 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,749,268 | 1,431,071 | -318,197 | 0.16 | 0.13 | -0.03 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 643,356 | 1,426,834 | +783,478 | 0.05 | 0.12 | +0.07 | buy |
| D. E. Shaw & Co., Inc. | 344,763 | 1,261,018 | +916,255 | 0.01 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 1,267,241 | 1,218,773 | -48,468 | 1.50 | 1.50 | +0.01 | sell |
| Candriam S.C.A. | 799,384 | 1,096,182 | +296,798 | 0.09 | 0.12 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 1,213,928 | 1,046,546 | -167,382 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 914,760 | +914,760 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 893,295 | +893,295 | 0.00 | 0.03 | +0.03 | buy |
| Eagle Health Investments LP | 0 | 884,121 | +884,121 | 0.00 | 3.89 | +3.89 | buy |
| Catalio Capital Management, LP | 162,550 | 850,797 | +688,247 | 0.66 | 3.72 | +3.06 | buy |
| UBS Group AG | 668,811 | 832,740 | +163,929 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 300,623 | 809,333 | +508,710 | 1.44 | 2.92 | +1.47 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,554,366 | 804,109 | -750,257 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 801,473 | 662,054 | -139,419 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 501,679 | 613,229 | +111,550 | 0.04 | 0.03 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,231,331 | 603,571 | -627,760 | 0.03 | 0.01 | -0.01 | sell |
| Palo Alto Investors LP | 461,294 | 596,495 | +135,201 | 1.48 | 1.91 | +0.43 | buy |
| Legal & General Group Plc | 411,273 | 590,294 | +179,021 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 366,100 | 561,700 | +195,600 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 598,924 | 558,486 | -40,438 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 526,686 | 535,566 | +8,880 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,316 | 524,798 | +372,482 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 115,928 | 504,143 | +388,215 | 0.03 | 0.16 | +0.12 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 263,869 | 500,922 | +237,053 | 0.02 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 741,618 | 494,737 | -246,881 | 0.09 | 0.08 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 903,050 | 490,783 | -412,267 | 0.01 | 0.01 | -0.01 | sell |
| Ikarian Capital, LLC | 12,671 | 482,571 | +469,900 | 0.04 | 1.45 | +1.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | 480,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 331,169 | 451,119 | +119,950 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 390,599 | 444,539 | +53,940 | 0.02 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 219,232 | 428,529 | +209,297 | 0.08 | 0.14 | +0.06 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,899,661 | 418,149 | -1,481,512 | 0.05 | 0.01 | -0.04 | sell |
| Russell Investments Group, Ltd. | 840,820 | 402,959 | -437,861 | 0.02 | 0.01 | -0.01 | sell |
| Newtyn Management, LLC | 295,915 | 400,000 | +104,085 | 0.72 | 0.90 | +0.18 | buy |
| Krensavage Asset Management, LLC | 149,634 | 390,879 | +241,245 | 1.22 | 3.20 | +1.99 | buy |
| Trexquant Investment LP | 165,017 | 389,467 | +224,450 | 0.03 | 0.06 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 520,054 | 384,364 | -135,690 | 0.02 | 0.02 | -0.01 | sell |
| Privium Fund Management B.V. | 357,502 | 364,802 | +7,300 | 1.51 | 1.59 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 400,358 | 353,097 | -47,261 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 347,760 | +347,760 | 0.00 | 0.23 | +0.23 | buy |
| Bank of New York Mellon Corp | 298,706 | 341,125 | +42,419 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 69,511 | 315,440 | +245,929 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 309,062 | 312,628 | +3,566 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 212,638 | 302,638 | +90,000 | 1.51 | 1.70 | +0.19 | buy |
| FRED ALGER MANAGEMENT, LLC | 411,863 | 298,032 | -113,831 | 0.04 | 0.03 | -0.01 | sell |
| Invesco Ltd. | 230,271 | 289,572 | +59,301 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,666,249 | 287,316 | -2,378,933 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 310,108 | 260,385 | -49,723 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 359,148 | 249,807 | -109,341 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 3,974,030 | 245,928 | -3,728,102 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 62,030 | 235,000 | +172,970 | 0.14 | 0.51 | +0.37 | buy |
| Longaeva Partners L.P. | 0 | 228,107 | +228,107 | 0.00 | 0.23 | +0.23 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 204,107 | 223,048 | +18,941 | 0.00 | 0.00 | -0.00 | buy |
| Motley Fool Wealth Management, LLC | 297,486 | 222,981 | -74,505 | 0.53 | 0.53 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 219,291 | +219,291 | 0.00 | 0.10 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 218,354 | +218,354 | 0.00 | 0.09 | +0.09 | buy |
| Brevan Howard Capital Management LP | 107,903 | 215,845 | +107,942 | 0.05 | 0.05 | -0.00 | buy |
| Man Group plc | 78,371 | 213,352 | +134,981 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 49,750 | 187,508 | +137,758 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 175,635 | 179,097 | +3,462 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 1,021,499 | 173,743 | -847,756 | 0.03 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 171,805 | 171,805 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Swiss National Bank | 171,052 | 171,052 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 157,061 | 165,431 | +8,370 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 72,168 | 157,526 | +85,358 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 200,000 | 157,132 | -42,868 | 0.09 | 0.12 | +0.03 | sell |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 96,908 | 150,587 | +53,679 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 141,978 | +141,978 | 0.00 | 0.07 | +0.07 | buy |
| GROUP ONE TRADING LLC | 23,208 | 140,166 | +116,958 | 0.02 | 0.10 | +0.08 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 137,753 | 137,753 | 0 | 0.45 | 0.32 | -0.13 | hold |
| Corient Private Wealth LLC | 0 | 136,544 | +136,544 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 135,000 | 135,000 | 0 | 2.30 | 2.10 | -0.20 | hold |
| CAPITAL FUND MANAGEMENT S.A. | 150,201 | 121,374 | -28,827 | 0.03 | 0.02 | -0.01 | sell |
| Walleye Capital LLC | 36,484 | 119,705 | +83,221 | 0.00 | 0.02 | +0.01 | buy |
| FIFTH THIRD BANCORP | 0 | 110,272 | +110,272 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 219,500 | 110,000 | -109,500 | 0.22 | 0.11 | -0.11 | sell |
| Entropy Technologies, LP | 60,641 | 109,727 | +49,086 | 0.08 | 0.11 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,337 | 104,650 | +21,313 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 101,826 | 103,407 | +1,581 | 0.00 | 0.00 | -0.00 | buy |
| PINNACLE ASSOCIATES LTD | 111,560 | 102,710 | -8,850 | 0.03 | 0.03 | -0.01 | sell |
| Crestwood Advisors Group, LLC | 100,131 | 100,086 | -45 | 0.04 | 0.04 | -0.00 | sell |
| AXQ CAPITAL, LP | 0 | 96,177 | +96,177 | 0.00 | 0.26 | +0.26 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,836 | 93,828 | -3,008 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 93,622 | +93,622 | 0.00 | 0.14 | +0.14 | buy |