| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| AQR CAPITAL MANAGEMENT LLC | 1,360,497 | 4,578,024 | +3,217,527 | 0.02 | 0.04 | +0.03 | buy |
| Sofinnova Investments, Inc. | 83,300 | 3,145,888 | +3,062,588 | 0.08 | 3.30 | +3.22 | buy |
| Bellevue Group AG | 2,580 | 2,380,000 | +2,377,420 | 0.00 | 1.19 | +1.19 | buy |
| Assenagon Asset Management S.A. | 199,720 | 2,257,671 | +2,057,951 | 0.01 | 0.08 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 424,049 | 2,205,820 | +1,781,771 | 0.01 | 0.04 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 344,763 | 1,261,018 | +916,255 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 914,760 | +914,760 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 893,295 | +893,295 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 880,644 | 1,772,184 | +891,540 | 0.01 | 0.03 | +0.01 | buy |
| Eagle Health Investments LP | 0 | 884,121 | +884,121 | 0.00 | 3.89 | +3.89 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 643,356 | 1,426,834 | +783,478 | 0.05 | 0.12 | +0.07 | buy |
| STATE STREET CORP | 4,303,046 | 5,021,441 | +718,395 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 162,550 | 850,797 | +688,247 | 0.66 | 3.72 | +3.06 | buy |
| BlackRock, Inc. | 6,631,554 | 7,299,598 | +668,044 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,000,139 | 3,648,795 | +648,656 | 0.69 | 0.76 | +0.07 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 300,623 | 809,333 | +508,710 | 1.44 | 2.92 | +1.47 | buy |
| Ikarian Capital, LLC | 12,671 | 482,571 | +469,900 | 0.04 | 1.45 | +1.41 | buy |
| Jump Financial, LLC | 115,928 | 504,143 | +388,215 | 0.03 | 0.16 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,316 | 524,798 | +372,482 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 347,760 | +347,760 | 0.00 | 0.23 | +0.23 | buy |
| Candriam S.C.A. | 799,384 | 1,096,182 | +296,798 | 0.09 | 0.12 | +0.03 | buy |
| CITIGROUP INC | 69,511 | 315,440 | +245,929 | 0.00 | 0.00 | +0.00 | buy |
| Krensavage Asset Management, LLC | 149,634 | 390,879 | +241,245 | 1.22 | 3.20 | +1.99 | buy |
| GW&K Investment Management, LLC | 1,375,407 | 1,615,426 | +240,019 | 0.27 | 0.30 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 263,869 | 500,922 | +237,053 | 0.02 | 0.02 | +0.01 | buy |
| Longaeva Partners L.P. | 0 | 228,107 | +228,107 | 0.00 | 0.23 | +0.23 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,965,084 | 2,191,182 | +226,098 | 0.48 | 0.47 | -0.01 | buy |
| Trexquant Investment LP | 165,017 | 389,467 | +224,450 | 0.03 | 0.06 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 219,291 | +219,291 | 0.00 | 0.10 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 218,354 | +218,354 | 0.00 | 0.09 | +0.09 | buy |
| ALGERT GLOBAL LLC | 219,232 | 428,529 | +209,297 | 0.08 | 0.14 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | 480,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 366,100 | 561,700 | +195,600 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 411,273 | 590,294 | +179,021 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,910 | 2,640,812 | +178,902 | 0.01 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 62,030 | 235,000 | +172,970 | 0.14 | 0.51 | +0.37 | buy |
| UBS Group AG | 668,811 | 832,740 | +163,929 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 141,978 | +141,978 | 0.00 | 0.07 | +0.07 | buy |
| Quantinno Capital Management LP | 49,750 | 187,508 | +137,758 | 0.00 | 0.01 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 136,544 | +136,544 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 461,294 | 596,495 | +135,201 | 1.48 | 1.91 | +0.43 | buy |
| Man Group plc | 78,371 | 213,352 | +134,981 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 331,169 | 451,119 | +119,950 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 23,208 | 140,166 | +116,958 | 0.02 | 0.10 | +0.08 | buy |
| HRT FINANCIAL LP | 501,679 | 613,229 | +111,550 | 0.04 | 0.03 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 110,272 | +110,272 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 107,903 | 215,845 | +107,942 | 0.05 | 0.05 | -0.00 | buy |
| Newtyn Management, LLC | 295,915 | 400,000 | +104,085 | 0.72 | 0.90 | +0.18 | buy |
| AXQ CAPITAL, LP | 0 | 96,177 | +96,177 | 0.00 | 0.26 | +0.26 | buy |
| Atom Investors LP | 0 | 93,622 | +93,622 | 0.00 | 0.14 | +0.14 | buy |
| Blue Owl Capital Holdings LP | 212,638 | 302,638 | +90,000 | 1.51 | 1.70 | +0.19 | buy |
| MARSHALL WACE, LLP | 72,168 | 157,526 | +85,358 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 36,484 | 119,705 | +83,221 | 0.00 | 0.02 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 83,196 | +83,196 | 0.00 | 0.14 | +0.14 | buy |
| NATIXIS | 0 | 81,754 | +81,754 | 0.00 | 0.01 | +0.01 | buy |
| Neo Ivy Capital Management | 0 | 73,601 | +73,601 | 0.00 | 0.41 | +0.41 | buy |
| Invesco Ltd. | 230,271 | 289,572 | +59,301 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 390,599 | 444,539 | +53,940 | 0.02 | 0.02 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 96,908 | 150,587 | +53,679 | 0.01 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 52,017 | +52,017 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 10,245 | 61,314 | +51,069 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 60,641 | 109,727 | +49,086 | 0.08 | 0.11 | +0.03 | buy |
| DAFNA Capital Management LLC | 16,000 | 61,100 | +45,100 | 0.09 | 0.29 | +0.21 | buy |
| CONGRESS ASSET MANAGEMENT CO | 0 | 44,908 | +44,908 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 298,706 | 341,125 | +42,419 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 13,416 | 53,517 | +40,101 | 0.00 | 0.01 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 39,473 | +39,473 | 0.00 | 0.16 | +0.16 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 37,136 | +37,136 | 0.00 | 0.13 | +0.13 | buy |
| DIADEMA PARTNERS LP | 0 | 35,144 | +35,144 | 0.00 | 0.30 | +0.30 | buy |
| Bridgefront Capital, LLC | 0 | 35,135 | +35,135 | 0.00 | 0.18 | +0.18 | buy |
| CWM, LLC | 13,125 | 44,571 | +31,446 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 31,378 | +31,378 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,129 | +27,129 | 0.00 | 0.04 | +0.04 | buy |
| IEQ CAPITAL, LLC | 0 | 26,333 | +26,333 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 26,261 | +26,261 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 26,119 | +26,119 | 0.00 | 0.16 | +0.16 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 0 | 23,850 | +23,850 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 28,207 | 50,800 | +22,593 | 0.05 | 0.12 | +0.07 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,706 | 34,174 | +22,468 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 29,679 | 51,637 | +21,958 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,780 | +21,780 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,337 | 104,650 | +21,313 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,266 | 32,435 | +21,169 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 19,924 | +19,924 | 0.00 | 0.02 | +0.02 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 13,965 | 33,785 | +19,820 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 49,137 | 68,803 | +19,666 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 204,107 | 223,048 | +18,941 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 0 | 18,000 | +18,000 | 0.00 | 0.02 | +0.02 | buy |
| DAVENPORT & Co LLC | 0 | 17,500 | +17,500 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 344 | 16,885 | +16,541 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 5,000 | 21,250 | +16,250 | 0.02 | 0.09 | +0.07 | buy |
| Cerity Partners LLC | 15,678 | 31,892 | +16,214 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 15,797 | +15,797 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 56,624 | 72,108 | +15,484 | 0.04 | 0.06 | +0.02 | buy |
| Amundi | 0 | 15,166 | +15,166 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 14,837 | +14,837 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 13,400 | +13,400 | 0.00 | 0.02 | +0.02 | buy |
| Knott David M Jr | 20,006 | 33,069 | +13,063 | 0.21 | 0.41 | +0.20 | buy |
| Engineers Gate Manager LP | 76,702 | 89,455 | +12,753 | 0.02 | 0.02 | +0.00 | buy |