| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 83,300 | 3,145,888 | +3,062,588 | 0.08 | 3.30 | +3.22 | buy |
| Bellevue Group AG | 2,580 | 2,380,000 | +2,377,420 | 0.00 | 1.19 | +1.19 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 643,356 | 1,426,834 | +783,478 | 0.05 | 0.12 | +0.07 | buy |
| RTW INVESTMENTS, LP | 3,000,139 | 3,648,795 | +648,656 | 0.69 | 0.76 | +0.07 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 300,623 | 809,333 | +508,710 | 1.44 | 2.92 | +1.47 | buy |
| Ikarian Capital, LLC | 12,671 | 482,571 | +469,900 | 0.04 | 1.45 | +1.41 | buy |
| Candriam S.C.A. | 799,384 | 1,096,182 | +296,798 | 0.09 | 0.12 | +0.03 | buy |
| Krensavage Asset Management, LLC | 149,634 | 390,879 | +241,245 | 1.22 | 3.20 | +1.99 | buy |
| Parkman Healthcare Partners LLC | 62,030 | 235,000 | +172,970 | 0.14 | 0.51 | +0.37 | buy |
| Palo Alto Investors LP | 461,294 | 596,495 | +135,201 | 1.48 | 1.91 | +0.43 | buy |
| Newtyn Management, LLC | 295,915 | 400,000 | +104,085 | 0.72 | 0.90 | +0.18 | buy |
| Blue Owl Capital Holdings LP | 212,638 | 302,638 | +90,000 | 1.51 | 1.70 | +0.19 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 96,908 | 150,587 | +53,679 | 0.01 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 16,000 | 61,100 | +45,100 | 0.09 | 0.29 | +0.21 | buy |
| Headlands Technologies LLC | 28,207 | 50,800 | +22,593 | 0.05 | 0.12 | +0.07 | buy |
| Knott David M Jr | 20,006 | 33,069 | +13,063 | 0.21 | 0.41 | +0.20 | buy |
| E Fund Management Co., Ltd. | 9,052 | 20,796 | +11,744 | 0.02 | 0.01 | -0.00 | buy |
| Privium Fund Management B.V. | 357,502 | 364,802 | +7,300 | 1.51 | 1.59 | +0.08 | buy |
| Motley Fool Asset Management LLC | 72,448 | 78,141 | +5,693 | 0.06 | 0.07 | +0.01 | buy |
| OAK RIDGE INVESTMENTS LLC | 13,394 | 16,228 | +2,834 | 0.02 | 0.02 | +0.00 | buy |
| Crestwood Advisors Group, LLC | 100,131 | 100,086 | -45 | 0.04 | 0.04 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 58,838 | 57,939 | -899 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 62,173 | 60,308 | -1,865 | 0.05 | 0.04 | -0.01 | sell |
| PINNACLE ASSOCIATES LTD | 111,560 | 102,710 | -8,850 | 0.03 | 0.03 | -0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 200,000 | 157,132 | -42,868 | 0.09 | 0.12 | +0.03 | sell |
| Rock Springs Capital Management LP | 1,267,241 | 1,218,773 | -48,468 | 1.50 | 1.50 | +0.01 | sell |
| Motley Fool Wealth Management, LLC | 297,486 | 222,981 | -74,505 | 0.53 | 0.53 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 100,152 | 16,954 | -83,198 | 0.16 | 0.04 | -0.13 | sell |
| PDT Partners, LLC | 176,813 | 15,405 | -161,408 | 0.26 | 0.02 | -0.24 | sell |
| Eversept Partners, LP | 317,182 | 62,575 | -254,607 | 0.41 | 0.09 | -0.32 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 3,485,724 | 3,214,533 | -271,191 | 0.24 | 0.26 | +0.02 | sell |
| Aberdeen Group plc | 1,469,951 | 38,499 | -1,431,452 | 0.05 | 0.00 | -0.05 | sell |