| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,700,007 | 9,780,493 | +1,080,486 | 0.01 | 0.01 | -0.00 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,859,447 | 5,354,750 | +1,495,303 | 0.50 | 0.65 | +0.14 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,097,975 | 4,556,167 | +458,192 | 0.03 | 0.03 | -0.00 | buy |
| RTW INVESTMENTS, LP | 7,087,115 | 3,259,927 | -3,827,188 | 4.88 | 2.07 | -2.81 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,568,873 | 2,991,958 | -576,915 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 2,851,250 | 2,697,101 | -154,149 | 0.01 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 2,400,854 | 2,353,804 | -47,050 | 0.09 | 0.08 | -0.01 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 2,241,832 | 2,241,832 | 0 | 0.58 | 0.47 | -0.10 | hold |
| FEDERATED HERMES, INC. | 1,938,680 | 2,107,025 | +168,345 | 0.21 | 0.21 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,676,811 | 2,061,426 | +384,615 | 3.30 | 3.46 | +0.16 | buy |
| Rock Springs Capital Management LP | 1,774,938 | 1,924,072 | +149,134 | 2.11 | 2.39 | +0.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 707,905 | 1,850,734 | +1,142,829 | 0.03 | 0.06 | +0.03 | buy |
| Vestal Point Capital, LP | 110,000 | 1,800,000 | +1,690,000 | 0.42 | 5.52 | +5.09 | buy |
| DEUTSCHE BANK AG\ | 1,207,225 | 1,782,340 | +575,115 | 0.03 | 0.03 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,482,471 | 1,527,875 | +45,404 | 0.02 | 0.02 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,339,826 | 1,505,458 | +165,632 | 0.01 | 0.01 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,466,547 | 1,466,547 | 0 | 0.86 | 0.77 | -0.09 | hold |
| Invesco Ltd. | 502,852 | 1,268,318 | +765,466 | 0.01 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 968,990 | 1,133,100 | +164,110 | 0.07 | 0.07 | -0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 1,125,000 | +975,000 | 0.01 | 0.09 | +0.07 | buy |
| NORGES BANK | 798,504 | 1,002,463 | +203,959 | 0.01 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 790,446 | 963,146 | +172,700 | 2.83 | 3.47 | +0.64 | buy |
| Avidity Partners Management LP | 933,500 | 960,000 | +26,500 | 1.55 | 1.68 | +0.13 | buy |
| BNP Paribas Asset Management Holding S.A. | 507,095 | 830,375 | +323,280 | 0.06 | 0.09 | +0.03 | buy |
| Avoro Capital Advisors LLC | 830,000 | 830,000 | 0 | 0.45 | 0.45 | +0.00 | hold |
| Bank of New York Mellon Corp | 911,656 | 781,943 | -129,713 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 440,798 | 716,947 | +276,149 | 0.16 | 0.23 | +0.07 | buy |
| Candriam S.C.A. | 517,597 | 688,942 | +171,345 | 0.15 | 0.17 | +0.02 | buy |
| FMR LLC | 782,032 | 647,618 | -134,414 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 687,619 | 634,327 | -53,292 | 0.14 | 0.11 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 364,122 | 629,514 | +265,392 | 0.00 | 0.01 | +0.00 | buy |
| Man Group plc | 153,641 | 628,726 | +475,085 | 0.02 | 0.07 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 415,314 | 568,309 | +152,995 | 0.05 | 0.06 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,036,374 | 556,818 | -479,556 | 0.05 | 0.03 | -0.03 | sell |
| FRED ALGER MANAGEMENT, LLC | 581,551 | 548,905 | -32,646 | 0.13 | 0.11 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 430,536 | 547,818 | +117,282 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 60,900 | 539,749 | +478,849 | 0.01 | 0.07 | +0.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 484,381 | 537,616 | +53,235 | 0.01 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 389,291 | 528,180 | +138,889 | 0.18 | 0.21 | +0.03 | buy |
| Eagle Health Investments LP | 299,700 | 524,500 | +224,800 | 2.67 | 3.85 | +1.19 | buy |
| MORGAN STANLEY | 504,382 | 497,969 | -6,413 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 488,138 | 486,682 | -1,456 | 0.92 | 0.84 | -0.08 | sell |
| TWO SIGMA ADVISERS, LP | 448,200 | 442,200 | -6,000 | 0.05 | 0.04 | -0.01 | sell |
| AXA S.A. | 332,767 | 425,334 | +92,567 | 0.05 | 0.05 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 425,000 | +425,000 | 0.00 | 0.82 | +0.82 | buy |
| Hudson Bay Capital Management LP | 305,100 | 415,000 | +109,900 | 0.12 | 0.13 | +0.00 | buy |
| GW&K Investment Management, LLC | 303,377 | 406,519 | +103,142 | 0.12 | 0.15 | +0.03 | buy |
| Walleye Capital LLC | 266,641 | 390,592 | +123,951 | 0.14 | 0.17 | +0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 385,340 | 390,524 | +5,184 | 0.94 | 0.84 | -0.10 | buy |
| NORTHERN TRUST CORP | 367,623 | 381,881 | +14,258 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 245,590 | 380,552 | +134,962 | 1.84 | 2.43 | +0.59 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 266,967 | 370,247 | +103,280 | 0.00 | 0.00 | +0.00 | buy |
| Cutter Capital Management, LP | 0 | 365,000 | +365,000 | 0.00 | 4.57 | +4.57 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 255,078 | 357,438 | +102,360 | 0.01 | 0.02 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 157,276 | 294,723 | +137,447 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 215,916 | 293,894 | +77,978 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 238,544 | 293,832 | +55,288 | 1.80 | 1.97 | +0.16 | buy |
| Aberdeen Group plc | 141,117 | 284,745 | +143,628 | 0.01 | 0.02 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 368,219 | 281,093 | -87,126 | 0.02 | 0.01 | -0.01 | sell |
| Artal Group S.A. | 177,932 | 275,000 | +97,068 | 0.21 | 0.29 | +0.08 | buy |
| Blue Owl Capital Holdings LP | 268,238 | 268,238 | 0 | 2.50 | 3.07 | +0.56 | hold |
| Woodline Partners LP | 400,124 | 266,790 | -133,334 | 0.17 | 0.11 | -0.07 | sell |
| Privium Fund Management B.V. | 215,102 | 251,602 | +36,500 | 2.68 | 2.63 | -0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 287,504 | 247,138 | -40,366 | 0.01 | 0.01 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 185,000 | 245,000 | +60,000 | 0.18 | 0.22 | +0.04 | buy |
| MACQUARIE GROUP LTD | 220,317 | 229,482 | +9,165 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 252,160 | 221,025 | -31,135 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 203,442 | +203,442 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 169,163 | 195,891 | +26,728 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 65,438 | 185,061 | +119,623 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130,260 | 176,809 | +46,549 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 293,305 | 173,948 | -119,357 | 0.01 | 0.01 | -0.01 | sell |
| Motley Fool Wealth Management, LLC | 164,076 | 170,400 | +6,324 | 0.40 | 0.36 | -0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 155,525 | 162,891 | +7,366 | 0.03 | 0.03 | -0.00 | buy |
| PINNACLE ASSOCIATES LTD | 119,387 | 161,020 | +41,633 | 0.09 | 0.10 | +0.02 | buy |
| Russell Investments Group, Ltd. | 163,141 | 156,053 | -7,088 | 0.01 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 152,500 | 154,675 | +2,175 | 0.02 | 0.02 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 220,360 | 149,084 | -71,276 | 0.01 | 0.01 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 119,339 | 148,813 | +29,474 | 0.16 | 0.18 | +0.02 | buy |
| Swiss National Bank | 145,852 | 145,852 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 0 | 145,000 | +145,000 | 0.00 | 0.13 | +0.13 | buy |
| Assenagon Asset Management S.A. | 142,174 | 142,174 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Motley Fool Asset Management LLC | 146,526 | 141,289 | -5,237 | 0.44 | 0.39 | -0.06 | sell |
| Verition Fund Management LLC | 115,925 | 137,431 | +21,506 | 0.05 | 0.04 | -0.01 | buy |
| Cinctive Capital Management LP | 111,751 | 126,681 | +14,930 | 0.27 | 0.28 | +0.01 | buy |
| Rafferty Asset Management, LLC | 181,484 | 126,159 | -55,325 | 0.03 | 0.02 | -0.01 | sell |
| EFG Asset Management (North America) Corp. | 116,836 | 125,561 | +8,725 | 0.94 | 0.89 | -0.05 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,572 | 108,096 | +524 | 0.00 | 0.00 | -0.00 | buy |
| Crestwood Advisors Group, LLC | 100,258 | 100,280 | +22 | 0.10 | 0.09 | -0.02 | buy |
| Monashee Investment Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.53 | +0.53 | buy |
| Parkman Healthcare Partners LLC | 0 | 100,000 | +100,000 | 0.00 | 0.56 | +0.56 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 99,000 | 99,000 | 0 | 0.03 | 0.02 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 251,197 | 97,100 | -154,097 | 0.02 | 0.01 | -0.01 | sell |
| RHUMBLINE ADVISERS | 91,663 | 96,710 | +5,047 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 65,996 | 91,799 | +25,803 | 0.00 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 87,673 | 89,569 | +1,896 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 102,466 | 86,878 | -15,588 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 83,869 | 85,375 | +1,506 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,413 | 73,441 | -972 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 49,537 | 73,289 | +23,752 | 0.12 | 0.15 | +0.03 | buy |