| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 110,000 | 1,800,000 | +1,690,000 | 0.42 | 5.52 | +5.09 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,859,447 | 5,354,750 | +1,495,303 | 0.50 | 0.65 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 1,125,000 | +975,000 | 0.01 | 0.09 | +0.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,676,811 | 2,061,426 | +384,615 | 2.91 | 3.11 | +0.20 | buy |
| BNP Paribas Asset Management Holding S.A. | 507,095 | 830,375 | +323,280 | 0.06 | 0.09 | +0.03 | buy |
| Eagle Health Investments LP | 299,700 | 524,500 | +224,800 | 2.67 | 3.85 | +1.19 | buy |
| First Light Asset Management, LLC | 790,446 | 963,146 | +172,700 | 2.83 | 3.47 | +0.64 | buy |
| Candriam S.C.A. | 517,597 | 688,942 | +171,345 | 0.15 | 0.17 | +0.02 | buy |
| Rock Springs Capital Management LP | 1,774,938 | 1,924,072 | +149,134 | 2.10 | 2.38 | +0.28 | buy |
| Aberdeen Group plc | 141,117 | 284,745 | +143,628 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 389,291 | 528,180 | +138,889 | 0.18 | 0.21 | +0.03 | buy |
| MPM BioImpact LLC | 245,590 | 380,552 | +134,962 | 1.84 | 2.43 | +0.59 | buy |
| Hudson Bay Capital Management LP | 305,100 | 415,000 | +109,900 | 0.08 | 0.08 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 266,967 | 370,247 | +103,280 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 303,377 | 406,519 | +103,142 | 0.12 | 0.15 | +0.03 | buy |
| Artal Group S.A. | 177,932 | 275,000 | +97,068 | 0.21 | 0.29 | +0.08 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 185,000 | 245,000 | +60,000 | 0.14 | 0.17 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 238,544 | 293,832 | +55,288 | 1.56 | 1.65 | +0.08 | buy |
| PINNACLE ASSOCIATES LTD | 119,387 | 161,020 | +41,633 | 0.09 | 0.10 | +0.02 | buy |
| Privium Fund Management B.V. | 215,102 | 251,602 | +36,500 | 2.68 | 2.63 | -0.05 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 119,339 | 148,813 | +29,474 | 0.16 | 0.18 | +0.02 | buy |
| Avidity Partners Management LP | 933,500 | 960,000 | +26,500 | 1.55 | 1.68 | +0.13 | buy |
| Hennion & Walsh Asset Management, Inc. | 49,537 | 73,289 | +23,752 | 0.12 | 0.15 | +0.03 | buy |
| NEOS Investment Management LLC | 31,860 | 48,918 | +17,058 | 0.09 | 0.08 | -0.01 | buy |
| Cinctive Capital Management LP | 111,751 | 126,681 | +14,930 | 0.27 | 0.28 | +0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 10,370 | 21,070 | +10,700 | 0.12 | 0.19 | +0.08 | buy |
| Maven Securities LTD | 10,000 | 20,000 | +10,000 | 0.03 | 0.02 | -0.01 | buy |
| EFG Asset Management (North America) Corp. | 116,836 | 125,561 | +8,725 | 0.94 | 0.89 | -0.05 | buy |
| Motley Fool Wealth Management, LLC | 164,076 | 170,400 | +6,324 | 0.40 | 0.36 | -0.04 | buy |
| GREAT LAKES ADVISORS, LLC | 26,225 | 32,521 | +6,296 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 385,340 | 390,524 | +5,184 | 0.94 | 0.84 | -0.10 | buy |
| INCEPTIONR LLC | 4,289 | 8,477 | +4,188 | 0.05 | 0.10 | +0.05 | buy |
| PITCAIRN CO | 7,957 | 12,040 | +4,083 | 0.02 | 0.03 | +0.01 | buy |
| DnB Asset Management AS | 10,021 | 12,942 | +2,921 | 0.00 | 0.00 | +0.00 | buy |
| WOODSTOCK CORP | 11,124 | 13,871 | +2,747 | 0.05 | 0.06 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 17,423 | 19,927 | +2,504 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 274 | 2,531 | +2,257 | 0.01 | 0.15 | +0.14 | buy |
| Angeles Investment Advisors, LLC | 4,447 | 6,640 | +2,193 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 152,500 | 154,675 | +2,175 | 0.02 | 0.02 | -0.00 | buy |
| Crestwood Advisors Group, LLC | 100,258 | 100,280 | +22 | 0.10 | 0.09 | -0.02 | buy |
| MEEDER ASSET MANAGEMENT INC | 87 | 90 | +3 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 52,474 | 52,475 | +1 | 0.23 | 0.20 | -0.03 | buy |
| Simplify Asset Management Inc. | 30,753 | 30,651 | -102 | 0.14 | 0.11 | -0.03 | sell |
| VIRTUS ADVISERS, LLC | 8,299 | 7,638 | -661 | 0.21 | 0.15 | -0.05 | sell |
| E Fund Management Co., Ltd. | 8,577 | 7,662 | -915 | 0.02 | 0.02 | -0.01 | sell |
| EMERALD ADVISERS, LLC | 488,138 | 486,682 | -1,456 | 0.92 | 0.84 | -0.08 | sell |
| NFJ INVESTMENT GROUP, LLC | 43,962 | 39,893 | -4,069 | 0.06 | 0.05 | -0.01 | sell |
| Motley Fool Asset Management LLC | 146,526 | 141,289 | -5,237 | 0.44 | 0.39 | -0.06 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 10,370 | 4,900 | -5,470 | 0.12 | 0.05 | -0.07 | sell |
| China Universal Asset Management Co., Ltd. | 15,817 | 9,766 | -6,051 | 0.09 | 0.06 | -0.04 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 45,043 | 37,813 | -7,230 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 41,000 | 32,255 | -8,745 | 0.14 | 0.10 | -0.04 | sell |
| Susquehanna Portfolio Strategies, LLC | 24,147 | 7,147 | -17,000 | 0.03 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 581,551 | 548,905 | -32,646 | 0.13 | 0.11 | -0.02 | sell |
| Clearbridge Investments, LLC | 2,400,854 | 2,353,804 | -47,050 | 0.09 | 0.08 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 687,619 | 634,327 | -53,292 | 0.14 | 0.11 | -0.04 | sell |
| Woodline Partners LP | 400,124 | 266,790 | -133,334 | 0.17 | 0.11 | -0.07 | sell |
| RTW INVESTMENTS, LP | 7,087,115 | 3,259,927 | -3,827,188 | 4.88 | 2.07 | -2.81 | sell |