| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9,996,226 | 10,213,422 | +217,196 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 6,158,266 | 6,256,145 | +97,879 | 0.00 | 0.00 | -0.00 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 4,163,561 | 3,943,485 | -220,076 | 0.51 | 0.41 | -0.10 | sell |
| JPMORGAN CHASE & CO | 309,471 | 3,260,868 | +2,951,397 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,218,942 | 2,886,268 | -332,674 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,576,114 | 2,772,692 | +1,196,578 | 0.63 | 0.98 | +0.35 | buy |
| FMR LLC | 381,422 | 2,604,588 | +2,223,166 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,618,490 | 2,572,240 | -46,250 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,024,500 | 2,278,000 | +253,500 | 2.97 | 3.12 | +0.15 | buy |
| Clearbridge Investments, LLC | 2,259,705 | 2,140,577 | -119,128 | 0.07 | 0.06 | -0.01 | sell |
| FEDERATED HERMES, INC. | 2,055,200 | 2,049,501 | -5,699 | 0.16 | 0.14 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,449,498 | 1,871,820 | -577,678 | 0.02 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,646,537 | 1,712,931 | +66,394 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 1,707,402 | 1,707,402 | 0 | 0.95 | 0.88 | -0.06 | hold |
| Pictet Asset Management Holding SA | 1,409,199 | 1,699,944 | +290,745 | 0.06 | 0.06 | +0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,685,729 | 1,685,729 | 0 | 0.36 | 0.30 | -0.06 | hold |
| DEUTSCHE BANK AG\ | 1,701,493 | 1,665,852 | -35,641 | 0.02 | 0.02 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,149,000 | 1,529,474 | -619,526 | 0.14 | 0.09 | -0.05 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,150,456 | 1,452,130 | +301,674 | 0.11 | 0.13 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 1,495,351 | 1,429,437 | -65,914 | 0.22 | 0.18 | -0.03 | sell |
| Rock Springs Capital Management LP | 1,394,434 | 1,391,072 | -3,362 | 2.89 | 3.15 | +0.26 | sell |
| Deep Track Capital, LP | 1,350,000 | 1,350,000 | 0 | 1.58 | 1.58 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 1,247,380 | 1,255,203 | +7,823 | 0.02 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 215,890 | 1,163,755 | +947,865 | 0.01 | 0.07 | +0.05 | buy |
| Frazier Life Sciences Management, L.P. | 658,715 | 983,715 | +325,000 | 1.09 | 1.43 | +0.34 | buy |
| NORGES BANK | 983,638 | 983,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 898,000 | +898,000 | 0.00 | 0.15 | +0.15 | buy |
| TWO SIGMA ADVISERS, LP | 937,200 | 860,400 | -76,800 | 0.08 | 0.06 | -0.01 | sell |
| Invesco Ltd. | 1,213,282 | 724,115 | -489,167 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 626,400 | 638,879 | +12,479 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 527,980 | 637,690 | +109,710 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 627,600 | 627,600 | 0 | 5.90 | 5.63 | -0.27 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 593,121 | 615,969 | +22,848 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 852,657 | 606,407 | -246,250 | 0.30 | 0.18 | -0.12 | sell |
| TWO SIGMA INVESTMENTS, LP | 633,152 | 576,901 | -56,251 | 0.05 | 0.04 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 824,418 | 567,175 | -257,243 | 0.20 | 0.16 | -0.05 | sell |
| Polar Capital Holdings Plc | 651,383 | 551,383 | -100,000 | 0.14 | 0.11 | -0.04 | sell |
| LOOMIS SAYLES & CO L P | 561,479 | 549,538 | -11,941 | 0.03 | 0.03 | -0.00 | sell |
| First Light Asset Management, LLC | 632,033 | 547,905 | -84,128 | 2.61 | 2.58 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 556,417 | 540,801 | -15,616 | 0.02 | 0.02 | -0.00 | sell |
| Candriam S.C.A. | 728,017 | 526,267 | -201,750 | 0.17 | 0.11 | -0.05 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 525,464 | +525,464 | 0.00 | 0.18 | +0.18 | buy |
| Point72 Asset Management, L.P. | 976,052 | 515,968 | -460,084 | 0.10 | 0.04 | -0.05 | sell |
| Nuveen, LLC | 518,543 | 505,152 | -13,391 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 478,904 | 501,056 | +22,152 | 0.03 | 0.03 | -0.00 | buy |
| NORTHERN TRUST CORP | 568,389 | 493,470 | -74,919 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 502,023 | 486,632 | -15,391 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 712,393 | 486,341 | -226,052 | 0.03 | 0.02 | -0.01 | sell |
| GW&K Investment Management, LLC | 502,211 | 481,288 | -20,923 | 0.17 | 0.16 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 600,446 | 475,156 | -125,290 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 696,161 | 473,887 | -222,274 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 516,228 | 461,402 | -54,826 | 0.84 | 0.61 | -0.23 | sell |
| AXA S.A. | 456,295 | 456,666 | +371 | 0.05 | 0.05 | -0.01 | buy |
| UBS Group AG | 469,482 | 440,432 | -29,050 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 524,637 | 430,339 | -94,298 | 0.11 | 0.07 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 480,269 | 425,994 | -54,275 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 10,430 | 415,733 | +405,303 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 398,445 | 395,700 | -2,745 | 2.48 | 2.49 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 293,374 | 390,389 | +97,015 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 264,285 | 336,173 | +71,888 | 0.01 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 830,000 | 330,000 | -500,000 | 0.47 | 0.21 | -0.26 | sell |
| Legal & General Group Plc | 258,967 | 313,804 | +54,837 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 311,101 | 311,101 | 0 | 0.01 | 0.01 | -0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 303,565 | +303,565 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 232,360 | 300,962 | +68,602 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 340,975 | 295,317 | -45,658 | 0.88 | 0.65 | -0.22 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 240,000 | 290,000 | +50,000 | 0.29 | 0.21 | -0.08 | buy |
| Motley Fool Wealth Management, LLC | 149,596 | 275,082 | +125,486 | 0.32 | 0.60 | +0.28 | buy |
| Woodline Partners LP | 268,462 | 273,251 | +4,789 | 0.06 | 0.05 | -0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 270,000 | +270,000 | 0.00 | 0.37 | +0.37 | buy |
| Hudson Bay Capital Management LP | 380,200 | 258,681 | -121,519 | 0.09 | 0.06 | -0.03 | sell |
| Blue Owl Capital Holdings LP | 153,238 | 255,238 | +102,000 | 1.79 | 3.00 | +1.21 | buy |
| Privium Fund Management B.V. | 249,804 | 253,304 | +3,500 | 2.36 | 1.98 | -0.38 | buy |
| AQR CAPITAL MANAGEMENT LLC | 92,047 | 252,333 | +160,286 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 241,985 | +241,985 | 0.00 | 0.02 | +0.02 | buy |
| Caption Management, LLC | 178,828 | 237,500 | +58,672 | 0.30 | 0.79 | +0.50 | buy |
| MACQUARIE GROUP LTD | 283,549 | 235,097 | -48,452 | 0.01 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 268,666 | 234,912 | -33,754 | 0.11 | 0.10 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 176,851 | 225,826 | +48,975 | 0.00 | 0.01 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 213,402 | +213,402 | 0.00 | 1.63 | +1.63 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 202,213 | 210,469 | +8,256 | 0.02 | 0.02 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 299,600 | 208,300 | -91,300 | 0.02 | 0.01 | -0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 169,467 | 189,520 | +20,053 | 0.20 | 0.21 | +0.00 | buy |
| Fisher Asset Management, LLC | 207,755 | 185,756 | -21,999 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 455,148 | 184,177 | -270,971 | 0.05 | 0.01 | -0.03 | sell |
| BARCLAYS PLC | 142,881 | 178,611 | +35,730 | 0.00 | 0.00 | +0.00 | buy |
| Motley Fool Asset Management LLC | 84,473 | 167,448 | +82,975 | 0.17 | 0.28 | +0.11 | buy |
| Swiss National Bank | 161,052 | 161,052 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 104,921 | 156,693 | +51,772 | 0.27 | 0.32 | +0.05 | buy |
| Avidity Partners Management LP | 322,100 | 154,000 | -168,100 | 2.41 | 1.12 | -1.28 | sell |
| Parkman Healthcare Partners LLC | 304,244 | 147,980 | -156,264 | 1.31 | 0.62 | -0.68 | sell |
| EFG Asset Management (North America) Corp. | 122,942 | 135,850 | +12,908 | 0.74 | 0.70 | -0.04 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 130,422 | +130,422 | 0.00 | 5.91 | +5.91 | buy |
| TD ASSET MANAGEMENT INC | 138,484 | 123,884 | -14,600 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 16,888 | 123,127 | +106,239 | 0.01 | 0.05 | +0.04 | buy |
| Russell Investments Group, Ltd. | 103,822 | 120,195 | +16,373 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 130,320 | 116,347 | -13,973 | 0.12 | 0.09 | -0.03 | sell |
| PINNACLE ASSOCIATES LTD | 143,375 | 114,268 | -29,107 | 0.08 | 0.06 | -0.02 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 140,446 | 112,509 | -27,937 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 165,647 | 111,726 | -53,921 | 0.01 | 0.01 | -0.00 | sell |