| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,576,114 | 2,772,692 | +1,196,578 | 0.63 | 0.98 | +0.35 | buy |
| Frazier Life Sciences Management, L.P. | 658,715 | 983,715 | +325,000 | 1.09 | 1.43 | +0.34 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,024,500 | 2,278,000 | +253,500 | 2.72 | 2.50 | -0.22 | buy |
| Motley Fool Wealth Management, LLC | 149,596 | 275,082 | +125,486 | 0.32 | 0.60 | +0.28 | buy |
| GILDER GAGNON HOWE & CO LLC | 16,888 | 123,127 | +106,239 | 0.01 | 0.05 | +0.04 | buy |
| Blue Owl Capital Holdings LP | 153,238 | 255,238 | +102,000 | 1.79 | 3.00 | +1.21 | buy |
| Motley Fool Asset Management LLC | 84,473 | 167,448 | +82,975 | 0.17 | 0.28 | +0.11 | buy |
| B Group, Inc. | 47,500 | 110,000 | +62,500 | 1.49 | 3.45 | +1.96 | buy |
| PDT Partners, LLC | 104,921 | 156,693 | +51,772 | 0.27 | 0.32 | +0.05 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 240,000 | 290,000 | +50,000 | 0.18 | 0.13 | -0.05 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 32,535 | 67,720 | +35,185 | 0.83 | 0.01 | -0.82 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 37,667 | 60,176 | +22,509 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 478,904 | 501,056 | +22,152 | 0.03 | 0.03 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 169,467 | 189,520 | +20,053 | 0.20 | 0.21 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 122,942 | 135,850 | +12,908 | 0.74 | 0.70 | -0.04 | buy |
| Rhenman & Partners Asset Management AB | 82,000 | 93,100 | +11,100 | 0.34 | 0.43 | +0.09 | buy |
| Hennion & Walsh Asset Management, Inc. | 61,160 | 70,637 | +9,477 | 0.10 | 0.10 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 202,213 | 210,469 | +8,256 | 0.02 | 0.02 | -0.00 | buy |
| S&CO INC | 20,255 | 25,255 | +5,000 | 0.05 | 0.06 | +0.01 | buy |
| Woodline Partners LP | 268,462 | 273,251 | +4,789 | 0.06 | 0.05 | -0.01 | buy |
| Knott David M Jr | 48,000 | 52,000 | +4,000 | 0.82 | 0.86 | +0.04 | buy |
| Entropy Technologies, LP | 7,549 | 11,336 | +3,787 | 0.03 | 0.03 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 7,655 | 11,311 | +3,656 | 0.08 | 0.14 | +0.06 | buy |
| Privium Fund Management B.V. | 249,804 | 253,304 | +3,500 | 2.36 | 1.98 | -0.38 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 21,290 | 23,814 | +2,524 | 0.89 | 1.21 | +0.31 | buy |
| Erste Asset Management GmbH | 15,010 | 17,421 | +2,411 | 0.01 | 0.01 | -0.00 | buy |
| Birchview Capital, LP | 16,000 | 18,000 | +2,000 | 0.50 | 0.65 | +0.15 | buy |
| F/m Investments LLC | 58,314 | 59,102 | +788 | 0.08 | 0.08 | -0.01 | buy |
| E Fund Management Co., Ltd. | 8,300 | 9,052 | +752 | 0.01 | 0.02 | +0.00 | buy |
| DnB Asset Management AS | 14,268 | 14,720 | +452 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,554 | 18,988 | +434 | 0.06 | 0.06 | +0.00 | buy |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 35,695 | 35,805 | +110 | 0.03 | 0.02 | -0.00 | buy |
| Washington Trust Advisors, Inc. | 8 | 79 | +71 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 6,922 | 6,977 | +55 | 0.00 | 0.00 | -0.00 | buy |
| Crestwood Advisors Group, LLC | 100,730 | 100,729 | -1 | 0.07 | 0.07 | -0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 19,969 | 19,669 | -300 | 0.01 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 10,982 | 10,575 | -407 | 0.18 | 0.19 | +0.01 | sell |
| WOODSTOCK CORP | 13,871 | 13,287 | -584 | 0.05 | 0.04 | -0.01 | sell |
| PITCAIRN CO | 6,700 | 5,974 | -726 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 17,757 | 16,895 | -862 | 0.05 | 0.04 | -0.01 | sell |
| PROFUND ADVISORS LLC | 17,580 | 16,166 | -1,414 | 0.03 | 0.02 | -0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 13,311 | 11,822 | -1,489 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 16,900 | 15,210 | -1,690 | 0.03 | 0.03 | +0.00 | sell |
| MPM BioImpact LLC | 398,445 | 395,700 | -2,745 | 2.48 | 2.49 | +0.01 | sell |
| Rock Springs Capital Management LP | 1,394,434 | 1,391,072 | -3,362 | 2.89 | 3.15 | +0.26 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 22,370 | 14,730 | -7,640 | 0.16 | 0.10 | -0.06 | sell |
| LOOMIS SAYLES & CO L P | 561,479 | 549,538 | -11,941 | 0.03 | 0.03 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 502,023 | 486,632 | -15,391 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Hong Kong Ltd | 32,740 | 17,321 | -15,419 | 0.08 | 0.04 | -0.03 | sell |
| BIT Capital GmbH | 21,655 | 2,055 | -19,600 | 0.07 | 0.00 | -0.06 | sell |
| GW&K Investment Management, LLC | 502,211 | 481,288 | -20,923 | 0.17 | 0.16 | -0.01 | sell |
| Fisher Asset Management, LLC | 207,755 | 185,756 | -21,999 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 143,375 | 114,268 | -29,107 | 0.08 | 0.06 | -0.02 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 340,975 | 295,317 | -45,658 | 0.88 | 0.65 | -0.22 | sell |
| EMERALD ADVISERS, LLC | 516,228 | 461,402 | -54,826 | 0.84 | 0.61 | -0.23 | sell |
| Cinctive Capital Management LP | 77,261 | 18,731 | -58,530 | 0.22 | 0.04 | -0.18 | sell |
| Alyeska Investment Group, L.P. | 1,495,351 | 1,429,437 | -65,914 | 0.22 | 0.18 | -0.03 | sell |
| First Light Asset Management, LLC | 632,033 | 547,905 | -84,128 | 2.61 | 2.58 | -0.03 | sell |
| TWINBEECH CAPITAL LP | 95,404 | 10,789 | -84,615 | 0.06 | 0.01 | -0.05 | sell |
| FRED ALGER MANAGEMENT, LLC | 524,637 | 430,339 | -94,298 | 0.11 | 0.07 | -0.04 | sell |
| Polar Capital Holdings Plc | 651,383 | 551,383 | -100,000 | 0.14 | 0.11 | -0.04 | sell |
| Clearbridge Investments, LLC | 2,259,705 | 2,140,577 | -119,128 | 0.07 | 0.06 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 304,244 | 147,980 | -156,264 | 1.31 | 0.62 | -0.68 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 267,385 | 100,085 | -167,300 | 2.23 | 0.85 | -1.38 | sell |
| Avidity Partners Management LP | 322,100 | 154,000 | -168,100 | 2.41 | 1.12 | -1.28 | sell |
| Candriam S.C.A. | 728,017 | 526,267 | -201,750 | 0.17 | 0.11 | -0.05 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 4,163,561 | 3,943,485 | -220,076 | 0.51 | 0.41 | -0.10 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 852,657 | 606,407 | -246,250 | 0.30 | 0.18 | -0.12 | sell |
| Avoro Capital Advisors LLC | 830,000 | 330,000 | -500,000 | 0.47 | 0.21 | -0.26 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,149,000 | 1,529,474 | -619,526 | 0.14 | 0.09 | -0.05 | sell |