| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7,299,598 | 10,654,276 | +3,354,678 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 3,648,795 | 7,796,895 | +4,148,100 | 0.76 | 2.22 | +1.46 | buy |
| AQR CAPITAL MANAGEMENT LLC | 4,578,024 | 6,560,809 | +1,982,785 | 0.04 | 0.07 | +0.03 | buy |
| STATE STREET CORP | 5,021,441 | 6,158,766 | +1,137,325 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,205,820 | 3,621,200 | +1,415,380 | 0.04 | 0.09 | +0.05 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,214,533 | 3,158,368 | -56,165 | 0.26 | 0.39 | +0.13 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,431,071 | 2,939,719 | +1,508,648 | 0.13 | 0.35 | +0.23 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 2,191,182 | 2,847,936 | +656,754 | 0.47 | 0.89 | +0.41 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,849,391 | 2,578,828 | +729,437 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,380,000 | 1,982,775 | -397,225 | 1.19 | 1.39 | +0.21 | sell |
| D. E. Shaw & Co., Inc. | 1,261,018 | 1,730,193 | +469,175 | 0.02 | 0.04 | +0.01 | buy |
| Sofinnova Investments, Inc. | 3,145,888 | 1,717,505 | -1,428,383 | 3.30 | 3.06 | -0.24 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 480,000 | 1,580,000 | +1,100,000 | 0.02 | 0.07 | +0.06 | buy |
| GW&K Investment Management, LLC | 1,615,426 | 1,481,178 | -134,248 | 0.30 | 0.39 | +0.09 | sell |
| MPM BioImpact LLC | 0 | 1,418,215 | +1,418,215 | 0.00 | 2.89 | +2.89 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 804,109 | 1,356,501 | +552,392 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,500,528 | 1,324,805 | -175,723 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,640,812 | 1,250,464 | -1,390,348 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,426,834 | 1,241,556 | -185,278 | 0.12 | 0.18 | +0.06 | sell |
| BANK OF AMERICA CORP /DE/ | 1,046,546 | 1,148,454 | +101,908 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 1,096,182 | 1,001,841 | -94,341 | 0.12 | 0.15 | +0.03 | sell |
| Rock Springs Capital Management LP | 1,218,773 | 967,855 | -250,918 | 1.50 | 1.58 | +0.07 | sell |
| Jefferies Financial Group Inc. | 15,488 | 929,626 | +914,138 | 0.00 | 0.29 | +0.28 | buy |
| NORTHERN TRUST CORP | 535,566 | 920,314 | +384,748 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 884,121 | 884,121 | 0 | 3.89 | 4.89 | +1.00 | hold |
| Qube Research & Technologies Ltd | 914,760 | 882,219 | -32,541 | 0.03 | 0.03 | +0.01 | sell |
| Russell Investments Group, Ltd. | 402,959 | 781,912 | +378,953 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,772,184 | 760,825 | -1,011,359 | 0.03 | 0.02 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 760,039 | +760,039 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 558,486 | 760,039 | +201,553 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 603,571 | 753,695 | +150,124 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 662,054 | 693,959 | +31,905 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 832,740 | 657,699 | -175,041 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 596,495 | 596,495 | 0 | 1.91 | 2.75 | +0.84 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 809,333 | 588,494 | -220,839 | 2.92 | 2.81 | -0.10 | sell |
| Legal & General Group Plc | 590,294 | 586,520 | -3,774 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 586,230 | +586,230 | 0.00 | 0.06 | +0.06 | buy |
| FMR LLC | 287,316 | 576,849 | +289,533 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 353,097 | 575,338 | +222,241 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 389,467 | 556,385 | +166,918 | 0.06 | 0.11 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 490,783 | 498,167 | +7,384 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 245,928 | 493,126 | +247,198 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 341,125 | 470,697 | +129,572 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 162 | 415,000 | +414,838 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 561,700 | 413,700 | -148,000 | 0.02 | 0.02 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 418,149 | 409,255 | -8,894 | 0.01 | 0.01 | +0.00 | sell |
| Krensavage Asset Management, LLC | 390,879 | 390,879 | 0 | 3.20 | 4.96 | +1.76 | hold |
| ALGERT GLOBAL LLC | 428,529 | 389,964 | -38,565 | 0.14 | 0.15 | +0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 451,119 | 381,420 | -69,699 | 0.01 | 0.01 | +0.00 | sell |
| SummitTX Capital, L.P. | 347,760 | 374,270 | +26,510 | 0.23 | 0.33 | +0.10 | buy |
| Privium Fund Management B.V. | 364,802 | 338,800 | -26,002 | 1.59 | 2.08 | +0.49 | sell |
| Squarepoint Ops LLC | 444,539 | 338,368 | -106,171 | 0.02 | 0.02 | +0.00 | sell |
| Walleye Capital LLC | 119,705 | 334,854 | +215,149 | 0.02 | 0.05 | +0.04 | buy |
| Catalio Capital Management, LP | 850,797 | 316,252 | -534,545 | 3.72 | 1.98 | -1.74 | sell |
| FRANKLIN RESOURCES INC | 312,628 | 315,766 | +3,138 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 315,440 | 298,785 | -16,655 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 6,721 | 290,818 | +284,097 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 504,143 | 286,952 | -217,191 | 0.16 | 0.09 | -0.07 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 260,385 | 272,882 | +12,497 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 289,572 | 250,533 | -39,039 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 187,508 | 250,466 | +62,958 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 219,291 | 215,997 | -3,294 | 0.10 | 0.13 | +0.03 | sell |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 150,587 | 214,374 | +63,787 | 0.01 | 0.02 | +0.01 | buy |
| SEI INVESTMENTS CO | 92,094 | 211,833 | +119,739 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,115,491 | 210,531 | -1,904,960 | 0.03 | 0.00 | -0.03 | sell |
| Man Group plc | 213,352 | 195,110 | -18,242 | 0.01 | 0.01 | +0.00 | sell |
| FIFTH THIRD BANCORP | 110,272 | 193,236 | +82,964 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 500,922 | 191,578 | -309,344 | 0.02 | 0.01 | -0.01 | sell |
| Blue Owl Capital Holdings LP | 302,638 | 182,638 | -120,000 | 1.70 | 0.93 | -0.78 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 524,798 | 180,871 | -343,927 | 0.01 | 0.01 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 179,097 | 172,086 | -7,011 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 171,805 | 171,805 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Atom Investors LP | 93,622 | 171,771 | +78,149 | 0.14 | 0.51 | +0.37 | buy |
| Swiss National Bank | 171,052 | 167,652 | -3,400 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 223,048 | 167,226 | -55,822 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 482,571 | 165,617 | -316,954 | 1.45 | 0.91 | -0.54 | sell |
| DEUTSCHE BANK AG\ | 71,869 | 164,813 | +92,944 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 157,526 | 159,889 | +2,363 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 68,765 | 157,643 | +88,878 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,511 | 156,809 | +85,298 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 141,978 | 156,612 | +14,634 | 0.07 | 0.10 | +0.03 | buy |
| BARCLAYS PLC | 249,807 | 154,876 | -94,931 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 62,575 | 154,130 | +91,555 | 0.09 | 0.28 | +0.19 | buy |
| Ghisallo Capital Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| Corient Private Wealth LLC | 136,544 | 146,493 | +9,949 | 0.00 | 0.01 | +0.00 | buy |
| Mariner, LLC | 61,314 | 146,400 | +85,086 | 0.00 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 298,032 | 143,155 | -154,877 | 0.03 | 0.02 | -0.01 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 137,753 | 137,753 | 0 | 0.32 | 0.44 | +0.13 | hold |
| B Group, Inc. | 135,000 | 135,000 | 0 | 2.10 | 2.56 | +0.46 | hold |
| PINNACLE ASSOCIATES LTD | 102,710 | 131,104 | +28,394 | 0.03 | 0.05 | +0.02 | buy |
| Caption Management, LLC | 110,000 | 130,000 | +20,000 | 0.11 | 0.15 | +0.04 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 157,132 | 128,035 | -29,097 | 0.12 | 0.10 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,025 | 124,376 | +96,351 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 103,407 | 124,125 | +20,718 | 0.00 | 0.00 | +0.00 | buy |
| Apollon Wealth Management, LLC | 0 | 123,449 | +123,449 | 0.00 | 0.05 | +0.05 | buy |
| Assenagon Asset Management S.A. | 2,257,671 | 120,864 | -2,136,807 | 0.08 | 0.01 | -0.07 | sell |
| IEQ CAPITAL, LLC | 26,333 | 106,026 | +79,693 | 0.00 | 0.02 | +0.01 | buy |
| Cerity Partners LLC | 31,892 | 105,055 | +73,163 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 215,845 | 102,768 | -113,077 | 0.05 | 0.05 | +0.00 | sell |
| Rafferty Asset Management, LLC | 165,431 | 101,655 | -63,776 | 0.01 | 0.01 | -0.01 | sell |