| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 750,000 | 1,500,000 | +750,000 | 0.47 | 0.83 | +0.36 | buy |
| BAKER BROS. ADVISORS LP | 783,059 | 1,366,547 | +583,488 | 0.21 | 0.28 | +0.07 | buy |
| First Light Asset Management, LLC | 589,963 | 1,125,032 | +535,069 | 2.13 | 3.81 | +1.68 | buy |
| Hudson Bay Capital Management LP | 501,772 | 734,272 | +232,500 | 0.23 | 0.25 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 604,287 | 748,278 | +143,991 | 0.16 | 0.16 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 541,480 | 679,459 | +137,979 | 1.34 | 1.31 | -0.03 | buy |
| Rock Springs Capital Management LP | 1,384,269 | 1,476,441 | +92,172 | 1.52 | 1.41 | -0.11 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 183,696 | 259,135 | +75,439 | 1.82 | 2.22 | +0.40 | buy |
| Crestwood Advisors Group, LLC | 29,908 | 100,258 | +70,350 | 0.04 | 0.09 | +0.05 | buy |
| Motley Fool Asset Management LLC | 91,688 | 156,104 | +64,416 | 0.38 | 0.45 | +0.07 | buy |
| Motley Fool Wealth Management, LLC | 110,120 | 168,259 | +58,139 | 0.30 | 0.35 | +0.05 | buy |
| Ikarian Capital, LLC | 121,658 | 174,945 | +53,287 | 1.98 | 2.32 | +0.34 | buy |
| GREAT POINT PARTNERS LLC | 677,426 | 727,426 | +50,000 | 6.26 | 4.88 | -1.38 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 105,000 | 150,000 | +45,000 | 0.12 | 0.14 | +0.03 | buy |
| GW&K Investment Management, LLC | 286,471 | 310,915 | +24,444 | 0.13 | 0.11 | -0.01 | buy |
| SECTOR GAMMA AS | 100,605 | 115,166 | +14,561 | 1.04 | 1.05 | +0.01 | buy |
| DUALITY ADVISERS, LP | 14,323 | 27,038 | +12,715 | 0.08 | 0.12 | +0.03 | buy |
| HighVista Strategies LLC | 7,326 | 14,591 | +7,265 | 0.15 | 0.24 | +0.09 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 25,972 | 31,882 | +5,910 | 0.24 | 0.24 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 53,671 | 57,921 | +4,250 | 0.53 | 0.49 | -0.04 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 10,800 | 14,300 | +3,500 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 112,241 | 115,241 | +3,000 | 1.51 | 1.22 | -0.29 | buy |
| Corton Capital Inc. | 6,062 | 8,856 | +2,794 | 0.13 | 0.16 | +0.03 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 105,305 | 107,765 | +2,460 | 0.01 | 0.01 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,420 | 6,732 | +2,312 | 0.03 | 0.05 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 18,325 | 19,751 | +1,426 | 0.05 | 0.04 | -0.01 | buy |
| PROFUND ADVISORS LLC | 28,706 | 30,061 | +1,355 | 0.07 | 0.06 | -0.01 | buy |
| Headlands Technologies LLC | 2,224 | 3,351 | +1,127 | 0.03 | 0.06 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 928 | 1,831 | +903 | 0.01 | 0.02 | +0.01 | buy |
| DnB Asset Management AS | 11,826 | 12,674 | +848 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 8,693 | 9,404 | +711 | 0.03 | 0.03 | -0.01 | buy |
| LOOMIS SAYLES & CO L P | 85 | 152 | +67 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 46,337 | 46,386 | +49 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 1,494 | 1,481 | -13 | 0.01 | 0.01 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 9,648 | 9,592 | -56 | 0.01 | 0.01 | -0.00 | sell |
| Bridgewater Associates, LP | 11,962 | 11,389 | -573 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 6,860 | 6,072 | -788 | 0.19 | 0.13 | -0.06 | sell |
| PINNACLE ASSOCIATES LTD | 123,196 | 119,355 | -3,841 | 0.10 | 0.08 | -0.02 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 148,644 | 139,870 | -8,774 | 0.19 | 0.15 | -0.04 | sell |
| GREAT LAKES ADVISORS, LLC | 69,663 | 55,447 | -14,216 | 0.03 | 0.02 | -0.01 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 16,800 | 2,100 | -14,700 | 0.19 | 0.02 | -0.17 | sell |
| FRED ALGER MANAGEMENT, LLC | 656,105 | 638,866 | -17,239 | 0.15 | 0.13 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 107,600 | 90,000 | -17,600 | 0.01 | 0.01 | -0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 39,494 | 21,080 | -18,414 | 0.02 | 0.01 | -0.01 | sell |
| Woodline Partners LP | 236,564 | 205,483 | -31,081 | 0.13 | 0.09 | -0.04 | sell |
| NATIXIS | 64,700 | 33,100 | -31,600 | 0.03 | 0.01 | -0.02 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 440,141 | 387,323 | -52,818 | 1.10 | 0.83 | -0.27 | sell |
| EMERALD ADVISERS, LLC | 552,136 | 491,689 | -60,447 | 1.11 | 0.85 | -0.27 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 2,673,638 | 2,577,217 | -96,421 | 0.38 | 0.31 | -0.07 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 329,668 | 221,246 | -108,422 | 0.19 | 0.10 | -0.09 | sell |
| Avidity Partners Management LP | 900,700 | 544,000 | -356,700 | 1.45 | 0.78 | -0.67 | sell |
| Clearbridge Investments, LLC | 2,763,246 | 2,293,570 | -469,676 | 0.12 | 0.08 | -0.04 | sell |