| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9,780,493 | 9,945,473 | +164,980 | 0.01 | 0.01 | +0.00 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 5,354,750 | 5,118,255 | -236,495 | 0.65 | 0.86 | +0.22 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,556,167 | 4,165,424 | -390,743 | 0.03 | 0.04 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,991,958 | 3,068,654 | +76,696 | 0.01 | 0.02 | +0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 2,241,832 | 3,011,716 | +769,884 | 0.47 | 0.92 | +0.44 | buy |
| STATE STREET CORP | 2,697,101 | 2,664,077 | -33,024 | 0.00 | 0.01 | +0.00 | sell |
| Clearbridge Investments, LLC | 2,353,804 | 2,426,977 | +73,173 | 0.08 | 0.11 | +0.03 | buy |
| FEDERATED HERMES, INC. | 2,107,025 | 2,110,700 | +3,675 | 0.21 | 0.26 | +0.05 | buy |
| Rock Springs Capital Management LP | 1,924,072 | 1,978,272 | +54,200 | 2.39 | 3.58 | +1.19 | buy |
| RTW INVESTMENTS, LP | 3,259,927 | 1,968,002 | -1,291,925 | 2.07 | 1.58 | -0.49 | sell |
| DEUTSCHE BANK AG\ | 1,782,340 | 1,688,971 | -93,369 | 0.03 | 0.04 | +0.01 | sell |
| Invesco Ltd. | 1,268,318 | 1,674,269 | +405,951 | 0.01 | 0.02 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 1,466,547 | 1,576,114 | +109,567 | 0.77 | 0.91 | +0.14 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,505,458 | 1,571,081 | +65,623 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,527,875 | 1,546,265 | +18,390 | 0.02 | 0.03 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,125,000 | 1,525,741 | +400,741 | 0.09 | 0.15 | +0.06 | buy |
| Alyeska Investment Group, L.P. | 70,000 | 1,170,007 | +1,100,007 | 0.02 | 0.33 | +0.32 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,061,426 | 1,151,314 | -910,112 | 3.46 | 2.30 | -1.16 | sell |
| AQR CAPITAL MANAGEMENT LLC | 97,100 | 1,044,373 | +947,273 | 0.01 | 0.08 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 442,200 | 987,800 | +545,600 | 0.04 | 0.13 | +0.09 | buy |
| NORGES BANK | 1,002,463 | 940,626 | -61,837 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 547,818 | 925,910 | +378,092 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 830,000 | 830,000 | 0 | 0.45 | 0.67 | +0.22 | hold |
| MARSHALL WACE, LLP | 1,133,100 | 822,012 | -311,088 | 0.07 | 0.06 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 528,180 | 783,944 | +255,764 | 0.21 | 0.37 | +0.16 | buy |
| Bank of New York Mellon Corp | 781,943 | 772,085 | -9,858 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 568,309 | 755,683 | +187,374 | 0.06 | 0.09 | +0.04 | buy |
| First Light Asset Management, LLC | 963,146 | 755,102 | -208,044 | 3.47 | 3.49 | +0.02 | sell |
| Avidity Partners Management LP | 960,000 | 752,000 | -208,000 | 1.68 | 2.13 | +0.45 | sell |
| Vestal Point Capital, LP | 1,800,000 | 750,000 | -1,050,000 | 5.52 | 3.29 | -2.23 | sell |
| BNP Paribas Asset Management Holding S.A. | 830,375 | 724,182 | -106,193 | 0.09 | 0.10 | +0.01 | sell |
| Candriam S.C.A. | 688,942 | 713,092 | +24,150 | 0.17 | 0.23 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,850,734 | 710,689 | -1,140,045 | 0.06 | 0.03 | -0.03 | sell |
| Point72 Asset Management, L.P. | 539,749 | 653,660 | +113,911 | 0.07 | 0.13 | +0.05 | buy |
| FMR LLC | 647,618 | 637,821 | -9,797 | 0.00 | 0.00 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 425,000 | 633,715 | +208,715 | 0.82 | 1.41 | +0.59 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 537,616 | 594,521 | +56,905 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 486,682 | 569,798 | +83,116 | 0.84 | 1.22 | +0.38 | buy |
| Eagle Health Investments LP | 524,500 | 561,700 | +37,200 | 3.85 | 6.01 | +2.16 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 370,247 | 542,373 | +172,126 | 0.00 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 548,905 | 536,298 | -12,607 | 0.11 | 0.14 | +0.03 | sell |
| Pictet Asset Management Holding SA | 556,818 | 520,550 | -36,268 | 0.03 | 0.03 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 629,514 | 506,510 | -123,004 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 381,881 | 473,324 | +91,443 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 497,969 | 467,836 | -30,133 | 0.00 | 0.00 | +0.00 | sell |
| GW&K Investment Management, LLC | 406,519 | 466,569 | +60,050 | 0.15 | 0.22 | +0.07 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 390,524 | 429,302 | +38,778 | 0.84 | 1.24 | +0.40 | buy |
| AXA S.A. | 425,334 | 425,390 | +56 | 0.05 | 0.07 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 716,947 | 400,833 | -316,114 | 0.23 | 0.18 | -0.05 | sell |
| MPM BioImpact LLC | 380,552 | 329,733 | -50,819 | 2.43 | 2.75 | +0.32 | sell |
| Man Group plc | 628,726 | 327,203 | -301,523 | 0.07 | 0.05 | -0.02 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 294,723 | 294,723 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Cutter Capital Management, LP | 365,000 | 286,803 | -78,197 | 4.57 | 4.70 | +0.13 | sell |
| MACQUARIE GROUP LTD | 229,482 | 275,927 | +46,445 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 266,790 | 267,555 | +765 | 0.11 | 0.13 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 203,442 | 261,594 | +58,152 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 284,745 | 253,304 | -31,441 | 0.02 | 0.03 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 245,000 | 245,000 | 0 | 0.22 | 0.39 | +0.17 | hold |
| Privium Fund Management B.V. | 251,602 | 242,512 | -9,090 | 2.63 | 3.35 | +0.72 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 247,138 | 238,055 | -9,083 | 0.01 | 0.01 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 293,894 | 218,903 | -74,991 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 221,025 | 213,210 | -7,815 | 0.00 | 0.00 | +0.00 | sell |
| GREAT LAKES ADVISORS, LLC | 32,521 | 199,253 | +166,732 | 0.01 | 0.09 | +0.08 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 293,832 | 195,349 | -98,483 | 1.97 | 1.78 | -0.19 | sell |
| Hudson Bay Capital Management LP | 415,000 | 195,000 | -220,000 | 0.13 | 0.07 | -0.05 | sell |
| Cubist Systematic Strategies, LLC | 0 | 183,490 | +183,490 | 0.00 | 0.15 | +0.15 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 357,438 | 182,865 | -174,573 | 0.02 | 0.01 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 182,100 | +182,100 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 0 | 179,000 | +179,000 | 0.00 | 3.09 | +3.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 176,809 | 177,756 | +947 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 0 | 175,026 | +175,026 | 0.00 | 0.42 | +0.42 | buy |
| TD ASSET MANAGEMENT INC | 149,084 | 169,084 | +20,000 | 0.01 | 0.01 | +0.00 | buy |
| Motley Fool Wealth Management, LLC | 170,400 | 168,015 | -2,385 | 0.36 | 0.47 | +0.11 | sell |
| Trexquant Investment LP | 18,765 | 167,267 | +148,502 | 0.01 | 0.12 | +0.11 | buy |
| Blue Owl Capital Holdings LP | 268,238 | 163,238 | -105,000 | 3.07 | 1.76 | -1.31 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 86,878 | 162,093 | +75,215 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 145,852 | 159,152 | +13,300 | 0.00 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 142,174 | 145,433 | +3,259 | 0.01 | 0.02 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 154,675 | 145,349 | -9,326 | 0.02 | 0.02 | +0.00 | sell |
| Motley Fool Asset Management LLC | 141,289 | 141,649 | +360 | 0.39 | 0.47 | +0.09 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 148,813 | 134,204 | -14,609 | 0.18 | 0.23 | +0.05 | sell |
| JANE STREET GROUP, LLC | 185,061 | 131,441 | -53,620 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,871 | 120,337 | +95,466 | 0.00 | 0.01 | +0.01 | buy |
| PINNACLE ASSOCIATES LTD | 161,020 | 119,360 | -41,660 | 0.10 | 0.10 | -0.01 | sell |
| SEI INVESTMENTS CO | 91,799 | 116,137 | +24,338 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 108,096 | 114,119 | +6,023 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 96,710 | 110,292 | +13,582 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 109,468 | +9,468 | 0.56 | 0.78 | +0.22 | buy |
| EFG Asset Management (North America) Corp. | 125,561 | 109,388 | -16,173 | 0.89 | 1.02 | +0.12 | sell |
| Crestwood Advisors Group, LLC | 100,280 | 100,280 | 0 | 0.09 | 0.11 | +0.02 | hold |
| Rafferty Asset Management, LLC | 126,159 | 98,401 | -27,758 | 0.02 | 0.02 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 634,327 | 97,960 | -536,367 | 0.11 | 0.02 | -0.09 | sell |
| UBS Group AG | 195,891 | 93,069 | -102,822 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 85,375 | 92,836 | +7,461 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 89,569 | 89,569 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Russell Investments Group, Ltd. | 156,053 | 88,611 | -67,442 | 0.01 | 0.01 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,290 | 86,440 | +76,150 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 85,445 | +85,445 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 62,913 | 79,546 | +16,633 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 73,289 | 78,095 | +4,806 | 0.15 | 0.20 | +0.05 | buy |