| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Alyeska Investment Group, L.P. | 70,000 | 1,170,007 | +1,100,007 | 0.02 | 0.33 | +0.32 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 2,241,832 | 3,011,716 | +769,884 | 0.15 | 0.29 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,125,000 | 1,525,741 | +400,741 | 0.09 | 0.15 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 528,180 | 783,944 | +255,764 | 0.21 | 0.37 | +0.16 | buy |
| Frazier Life Sciences Management, L.P. | 425,000 | 633,715 | +208,715 | 0.82 | 1.41 | +0.59 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 370,247 | 542,373 | +172,126 | 0.00 | 0.01 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 32,521 | 199,253 | +166,732 | 0.01 | 0.09 | +0.08 | buy |
| BAKER BROS. ADVISORS LP | 1,466,547 | 1,576,114 | +109,567 | 0.77 | 0.91 | +0.14 | buy |
| EMERALD ADVISERS, LLC | 486,682 | 569,798 | +83,116 | 0.84 | 1.22 | +0.38 | buy |
| Clearbridge Investments, LLC | 2,353,804 | 2,426,977 | +73,173 | 0.08 | 0.11 | +0.03 | buy |
| GW&K Investment Management, LLC | 406,519 | 466,569 | +60,050 | 0.15 | 0.22 | +0.07 | buy |
| Rock Springs Capital Management LP | 1,924,072 | 1,978,272 | +54,200 | 2.38 | 3.58 | +1.20 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 390,524 | 429,302 | +38,778 | 0.84 | 1.24 | +0.40 | buy |
| Eagle Health Investments LP | 524,500 | 561,700 | +37,200 | 3.85 | 6.01 | +2.16 | buy |
| Candriam S.C.A. | 688,942 | 713,092 | +24,150 | 0.17 | 0.23 | +0.06 | buy |
| PDT Partners, LLC | 52,475 | 66,193 | +13,718 | 0.20 | 0.33 | +0.12 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 109,468 | +9,468 | 0.56 | 0.78 | +0.22 | buy |
| China Universal Asset Management Co., Ltd. | 9,766 | 17,726 | +7,960 | 0.06 | 0.11 | +0.05 | buy |
| INCEPTIONR LLC | 8,477 | 14,643 | +6,166 | 0.10 | 0.20 | +0.10 | buy |
| Hennion & Walsh Asset Management, Inc. | 73,289 | 78,095 | +4,806 | 0.15 | 0.20 | +0.05 | buy |
| nVerses Capital, LLC | 800 | 2,700 | +1,900 | 0.02 | 0.07 | +0.05 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 21,070 | 22,540 | +1,470 | 0.19 | 0.28 | +0.08 | buy |
| Woodline Partners LP | 266,790 | 267,555 | +765 | 0.11 | 0.13 | +0.02 | buy |
| Motley Fool Asset Management LLC | 141,289 | 141,649 | +360 | 0.39 | 0.47 | +0.09 | buy |
| GROUPAMA ASSET MANAGMENT | 729 | 948 | +219 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 19,927 | 19,589 | -338 | 0.01 | 0.01 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 19,350 | 18,622 | -728 | 0.08 | 0.09 | +0.01 | sell |
| Angeles Investment Advisors, LLC | 6,640 | 5,911 | -729 | 0.01 | 0.02 | +0.00 | sell |
| E Fund Management Co., Ltd. | 7,662 | 6,323 | -1,339 | 0.02 | 0.02 | +0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 37,813 | 36,427 | -1,386 | 0.00 | 0.00 | +0.00 | sell |
| PITCAIRN CO | 12,040 | 10,584 | -1,456 | 0.03 | 0.03 | +0.00 | sell |
| NFJ INVESTMENT GROUP, LLC | 39,893 | 38,131 | -1,762 | 0.05 | 0.06 | +0.01 | sell |
| BIT Capital GmbH | 32,255 | 29,870 | -2,385 | 0.10 | 0.15 | +0.05 | sell |
| Motley Fool Wealth Management, LLC | 170,400 | 168,015 | -2,385 | 0.36 | 0.47 | +0.11 | sell |
| DnB Asset Management AS | 12,942 | 10,243 | -2,699 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 48,918 | 45,599 | -3,319 | 0.08 | 0.08 | -0.01 | sell |
| Privium Fund Management B.V. | 251,602 | 242,512 | -9,090 | 2.63 | 3.35 | +0.72 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 154,675 | 145,349 | -9,326 | 0.02 | 0.02 | +0.00 | sell |
| TWINBEECH CAPITAL LP | 17,813 | 5,360 | -12,453 | 0.01 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 548,905 | 536,298 | -12,607 | 0.11 | 0.14 | +0.03 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 148,813 | 134,204 | -14,609 | 0.18 | 0.23 | +0.05 | sell |
| EFG Asset Management (North America) Corp. | 125,561 | 109,388 | -16,173 | 0.89 | 1.02 | +0.12 | sell |
| Aberdeen Group plc | 284,745 | 253,304 | -31,441 | 0.02 | 0.03 | +0.00 | sell |
| PINNACLE ASSOCIATES LTD | 161,020 | 119,360 | -41,660 | 0.10 | 0.10 | -0.01 | sell |
| MPM BioImpact LLC | 380,552 | 329,733 | -50,819 | 2.43 | 2.75 | +0.32 | sell |
| Cutter Capital Management, LP | 365,000 | 286,803 | -78,197 | 4.57 | 4.70 | +0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 293,832 | 195,349 | -98,483 | 1.65 | 1.73 | +0.08 | sell |
| Blue Owl Capital Holdings LP | 268,238 | 163,238 | -105,000 | 3.07 | 1.76 | -1.31 | sell |
| BNP Paribas Asset Management Holding S.A. | 830,375 | 724,182 | -106,193 | 0.09 | 0.10 | +0.01 | sell |
| Cinctive Capital Management LP | 126,681 | 15,902 | -110,779 | 0.28 | 0.05 | -0.23 | sell |
| Avidity Partners Management LP | 960,000 | 752,000 | -208,000 | 1.68 | 2.13 | +0.45 | sell |
| First Light Asset Management, LLC | 963,146 | 755,102 | -208,044 | 3.47 | 3.49 | +0.02 | sell |
| Hudson Bay Capital Management LP | 415,000 | 195,000 | -220,000 | 0.08 | 0.04 | -0.04 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 5,354,750 | 5,118,255 | -236,495 | 0.65 | 0.86 | +0.22 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 634,327 | 97,960 | -536,367 | 0.11 | 0.02 | -0.09 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,061,426 | 1,151,314 | -910,112 | 3.11 | 2.05 | -1.07 | sell |
| Vestal Point Capital, LP | 1,800,000 | 750,000 | -1,050,000 | 5.52 | 3.29 | -2.23 | sell |
| RTW INVESTMENTS, LP | 3,259,927 | 1,968,002 | -1,291,925 | 2.07 | 1.58 | -0.49 | sell |